School of Food Science and Nutrition

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Gary Williamson

Professor of Functional Foods
Research section: Food Chemistry and Biochemistry

Contact details

Room: G.14
Tel: +44 (0)113 3438380
Email: G.Williamson@leeds.ac.uk

Keywords

diet and health
flavonoids
phenolic acids
polyphenols
sugar
energy metabolism
pre-diabetes

Photograph of Gary Williamson

Research interests

Gary Williamson, originally a Biochemist and Enzymologist, is Professor of Functional Food in the School of Food Science and Nutrition, joining the School in 2007. Gary was previously Head of the Nutrient Bioavailability Group at the Nestle Research Center, Switzerland, since March 2002, and before that head of group at the BBSRC Institute of Food Research (IFR) in Norwich, UK, where he worked for 15 years. The group works in the areas of biochemistry, chemistry and cell/molecular biology, with the following research interests:

  1. Understanding aspects of absorption and metabolism of dietary plant flavonoids and phenolic acids, and how the metabolism influences biological effects.
  2. Understanding how polyphenols can affect cellular responses, signalling and gene expression, important for reducing the risk and incidence of diabetes.
  3. Promoting the use of physiologically relevant conditions and exploiting complex cellular systems to understand molecular mechanisms of action

    Gary has published over 360 refereed scientific publications and book chapters, and is an ISI highly cited author in Agricultural Sciences (h index of 71). He is a Fellow of the Royal Society for Chemistry (FRSC), was previously Editor-in Chief of the Royal Society of Chemistry journal, Food and Function, and was organizer and Chairman of 4th International Conference on Polyphenols and Health, December 2009. He has a wide range of scientific experience including more than 160 invited research seminars at International scientific conferences and Research Centers/Universities, supervision of 45 PhD students, and involvement, many as PI, in more than 25 intervention studies on human volunteers and patients. He has coordinated several multinational projects on phytochemicals and health and served as Director of a Europe-wide training programme for PhD students in phytochemicals at IFR. Whilst at Nestl Research Center, Lausanne, Switzerland, between 2002 and 2007, he was responsible for research on nutrient bioavailability. His research has been recognized by receipt of a prestigious indivdual European Research Council Advanced Grant (POLYTRUE?) which started in 2013. Scientific discoveries in the last 12 years include major advances in understanding dietary polyphenol bioavailability, including the structures of metabolites, their metabolic pathways and biological activities, and more recently their effects on sugar and energy metabolism. His research involves a wide variety of techniques including chromatography and mass spectrometry, cell models, human studies, enzyme assays, chemical and enzymic synthesis, gene expression, and biomarker measurement.

    Prof Williamson is a partner in the EU framework 7 project BACCHUS - Cardiovascular benefits from food bioactives

    Prof Williamson is a partner in the Plant food supplement Levels of Intake, Benefit and Risk Assessment, (PlantLIBRA) project funded by the EU.

    Useful links

    BBSRC, Diet and Health Research Industry Club grant: The effect of dietary bioactive compounds on skin health in humans in vivo.   
    You are what you ate a historical perspective supported by the Wellcome Trust   
       

    Publications

    Williamson G, Clifford MN Role of the small intestine, colon and microbiota in determining the metabolic fate of polyphenols Biochemical Pharmacology 139 24-39, 2017
    DOI:10.1016/j.bcp.2017.03.012
    View abstract

    Williamson G The role of polyphenols in modern nutrition Nutrition Bulletin 42 226-235, 2017
    DOI:10.1111/nbu.12278
    View abstract

    Van Rymenant E, Van Camp J, Pauwels B, Boydens C, Vanden Daele L, Beerens K, Brouckaert P, Smagghe G, Kerimi A, Williamson G, Grootaert C, Van de Voorde J Ferulic acid-4-O-sulfate rather than ferulic acid relaxes arteries and lowers blood pressure in mice Journal of Nutritional Biochemistry 44 44-51, 2017
    DOI:10.1016/j.jnutbio.2017.02.018
    View abstract

    Ifie I, Abrankó L, Villa-Rodriguez JA, Papp N, Ho P, Williamson G, Marshall LJ The effect of ageing temperature on the physicochemical properties, phytochemical profile andα-glucosidase inhibition of Hibiscus sabdariffa (roselle) wine Food Chemistry -, 2017
    DOI:10.1016/j.foodchem.2017.05.044
    View abstract

    Van Rymenant E, Abrankó L, Tumova S, Grootaert C, Van Camp J, Williamson G, Kerimi A Chronic exposure to short-chain fatty acids modulates transport and metabolism of microbiome-derived phenolics in human intestinal cells Journal of Nutritional Biochemistry 39 156-168, 2017
    DOI:10.1016/j.jnutbio.2016.09.009
    View abstract

    Tumova S, Kerimi A, Porter KE, Williamson G Transendothelial glucose transport is not restricted by extracellular hyperglycaemia Vascular Pharmacology 87 219-229, 2016
    DOI:10.1016/j.vph.2016.11.001
    View abstract

    Tumova S, Kerimi A, Porter KE, Williamson G Transendothelial glucose transport is not restricted by extracellular hyperglycaemia Heart 102 , 2016
    DOI:10.1136/heartjnl-2016-310696.21

    Nyambe-Silavwe H, Williamson G Polyphenol- and fibre-rich dried fruits with green tea attenuate starch-derived postprandial blood glucose and insulin: A randomised, controlled, single-blind, cross-over intervention British Journal of Nutrition 116 443-450, 2016
    DOI:10.1017/S0007114516002221
    View abstract

    Kerimi A, Williamson G At the interface of antioxidant signalling and cellular function: Key polyphenol effects Molecular Nutrition and Food Research 60 1770-1788, 2016
    DOI:10.1002/mnfr.201500940
    View abstract

    Yahya HM, Day A, Lawton C, Myrissa K, Croden F, Dye L, Williamson G Dietary intake of 20 polyphenol subclasses in a cohort of UK women European Journal of Nutrition 55 1839-1847, 2016
    DOI:10.1007/s00394-015-1001-3
    View abstract

    Ifie I, Marshall LJ, Ho P, Williamson G Hibiscus sabdariffa (Roselle) Extracts and Wine: Phytochemical Profile, Physicochemical Properties, and Carbohydrase Inhibition Journal of Agricultural and Food Chemistry 64 4921-4931, 2016
    DOI:10.1021/acs.jafc.6b01246
    View abstract

    Ziegler K, Kerimi A, Poquet L, Williamson G Butyric acid increases transepithelial transport of ferulic acid through upregulation of the monocarboxylate transporters SLC16A1 (MCT1) and SLC16A3 (MCT4) Archives of Biochemistry and Biophysics 599 3-12, 2016
    DOI:10.1016/j.abb.2016.01.018
    View abstract

    Charoenchon N, Rhodes LE, Nicolaou A, Williamson G, Farrar MD, Watson RE Dietary green tea catechins protect dermal elasic fibers from UV-induced remodeling JOURNAL OF INVESTIGATIVE DERMATOLOGY 136 , 2016

    Charoenchon N, Rhodes L, Nicolaou A, Williamson G, Farrar M, Watson R Impact of oral green tea catechin supplementation on the collagenous matrix following acute irradiation BRITISH JOURNAL OF DERMATOLOGY 174 , 2016

    Oladele EO, Williamson G Impact of resistant starch in three plantain (Musa AAB) products on glycaemic response of healthy volunteers European Journal of Nutrition 55 75-81, 2016
    DOI:10.1007/s00394-014-0825-6
    View abstract

    Shi Y, Williamson G Quercetin lowers plasma uric acid in pre-hyperuricaemic males: A randomised, double-blinded, placebo-controlled, cross-over trial British Journal of Nutrition 115 800-806, 2016
    DOI:10.1017/S0007114515005310
    View abstract

    Clarke KA, Dew TP, Watson REB, Farrar MD, Osman JE, Nicolaou A, Rhodes LE, Williamson G Green tea catechins and their metabolites in human skin before and after exposure to ultraviolet radiation Journal of Nutritional Biochemistry 27 203-210, 2016
    DOI:10.1016/j.jnutbio.2015.09.001
    View abstract

    Lai HTM, Threapleton DE, Day AJ, Williamson G, Cade JE, Burley VJ Fruit intake and cardiovascular disease mortality in the UK Women’s Cohort Study European Journal of Epidemiology 30 1035-1048, 2015
    DOI:10.1007/s10654-015-0050-5
    View abstract

    Wightman EL, Haskell-Ramsay CF, Reay JL, Williamson G, Dew T, Zhang W, Kennedy DO The effects of chronic trans-resveratrol supplementation on aspects of cognitive function, mood, sleep, health and cerebral blood flow in healthy, young humans British Journal of Nutrition -, 2015
    DOI:10.1017/S0007114515003037
    View abstract

    Actis-Goretta L, Dew TP, Lévèques A, Pereira-Caro G, Rein M, Teml A, Schäfer C, Hofmann U, Schwab M, Eichelbaum M, Crozier A, Williamson G Gastrointestinal absorption and metabolism of hesperetin-7-O-rutinoside and hesperetin-7-O-glucoside in healthy humans Molecular Nutrition and Food Research 59 1651-1662, 2015
    DOI:10.1002/mnfr.201500202
    View abstract

    Kerimi A, Williamson G The cardiovascular benefits of dark chocolate Vascular Pharmacology 71 11-15, 2015
    DOI:10.1016/j.vph.2015.05.011
    View abstract

    Farrar MD, Nicolaou A, Clarke KA, Mason S, Massey KA, Dew TP, Watson RE, Williamson G, Rhodes LE A randomized controlled trial of green tea catechins in protection against ultraviolet radiation-induced cutaneous inflammation. The American Journal of Clinical Nutrition 102 608-615, 2015
    DOI:10.3945/ajcn.115.107995
    View abstract

    Barrington RD, Needs PW, Williamson G, Kroon PA MK571 inhibits phase-2 conjugation of flavonols by Caco-2/TC7 cells, but does not specifically inhibit their apical efflux BIOCHEMICAL PHARMACOLOGY 95 193-200, 2015
    DOI:10.1016/j.bcp.2015.03.005

    Shi Y, Williamson G Comparison of the urinary excretion of quercetin glycosides from red onion and aglycone from dietary supplements in healthy subjects: A randomized, single-blinded, cross-over study. Food and Function 6 1443-1448, 2015
    DOI:10.1039/c5fo00155b
    View abstract

    Kerimi A, Jailani F, Williamson G Modulation of cellular glucose metabolism in human HepG2 cells by combinations of structurally related flavonoids Molecular Nutrition and Food Research 59 894-906, 2015
    DOI:10.1002/mnfr.201400850

    Pimpão RC, Ventura MR, Ferreira RB, Williamson G, Santos CN Phenolic sulfates as new and highly abundant metabolites in human plasma after ingestion of a mixed berry fruit purée British Journal of Nutrition 113 454-463, 2015
    DOI:10.1017/S0007114514003511
    View abstract

    Amarante da Encarnação J, Farrell TL, Ryder A, Kraut NU, Williamson G In vitro enzymic hydrolysis of chlorogenic acids in coffee Molecular Nutrition and Food Research 59 231-239, 2015
    DOI:10.1002/mnfr.201400498
    View abstract

    Courts FL, Williamson G The Occurrence, Fate and Biological Activities of C-glycosyl Flavonoids in the Human Diet Critical Reviews in Food Science and Nutrition 55 1352-1367, 2015
    DOI:10.1080/10408398.2012.694497
    View abstract

    Ziegler K, Tumova S, Kerimi A, Williamson G Cellular asymmetric catalysis by UDP-glucuronosyltransferase 1A8 shows functional localization to the basolateral plasma membrane. Journal of Biological Chemistry -, 2015
    DOI:10.1074/jbc.m114.634428
    View abstract

    Pimpão RC, Ventura MR, Ferreira RB, Williamson G, Santos CN Phenolic sulfates as new and highly abundant metabolites in human plasma after ingestion of a mixed berry fruit purée British Journal of Nutrition 113 454-463, 2015
    DOI:10.1017/S0007114514003511
    View abstract

    Nyambe-Silavwe H, Villa-Rodriguez JA, Ifie I, Holmes M, Aydin E, Jensen JM, Williamson G Inhibition of humanα-amylase by dietary polyphenols Journal of Functional Foods 19 723-732, 2015
    DOI:10.1016/j.jff.2015.10.003
    View abstract

    Lai HT, Holmes M, Williamson G, Burley VJ Fruit and vegetable intakes and the association with blood pressure within adults in the United Kingdom's National Diet&Nutrition Survey Rolling Programme (2008/09-2011/12) PROCEEDINGS OF THE NUTRITION SOCIETY 74 E318-E318, 2015
    DOI:10.1017/S0029665115003651

    Williamson G Bioavailability of Phytochemicals ANNALS OF NUTRITION AND METABOLISM 67 15-15, 2015

    Clarke KA, Dew TP, Watson REB, Farrar MD, Bennett S, Nicolaou A, Rhodes LE, Williamson G High performance liquid chromatography tandem mass spectrometry dual extraction method for identification of green tea catechin metabolites excreted in human urine Journal of Chromatography B 972 29-37, 2014
    DOI:10.1016/j.jchromb.2014.09.035
    View abstract

    Gasper A, Hollands W, Casgrain A, Saha S, Teucher B, Dainty JR, Venema DP, Hollman PC, Rein MJ, Nelson R, Williamson G, Kroon PA Consumption of both low and high (-)-epicatechin apple puree attenuates platelet reactivity and increases plasma concentrations of nitric oxide metabolites: A randomized controlled trial Archives of Biochemistry and Biophysics 559 29-37, 2014
    DOI:10.1016/j.abb.2014.05.026
    View abstract

    Gasper A, Hollands W, Casgrain A, Saha S, Teucher B, Dainty JR, Venema DP, Hollman PC, Rein MJ, Nelson R, Williamson G, Kroon PA Consumption of both low and high (-)-epicatechin apple puree attenuates platelet reactivity and increases plasma concentrations of nitric oxide metabolites: a randomized controlled trial. Arch Biochem Biophys 559 29-37, 2014
    DOI:10.1016/j.abb.2014.05.026
    View abstract

    Lai HT, Threapleton DE, Day AJ, Williamson G, Burley VJ, Cade JE TOTAL FRUIT INTAKE AND CARDIOVASCULAR DISEASE MORTALITY IN THE UK WOMEN'S COHORT STUDY (UKWCS) JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH 68 A9-A9, 2014
    DOI:10.1136/jech-2014-204726.15

    Wightman EL, Reay JL, Haskell CF, Williamson G, Dew TP, Kennedy DO Effects of resveratrol alone or in combination with piperine on cerebral blood flow parameters and cognitive performance in human subjects: A randomised, double-blind, placebo-controlled, cross-over investigation British Journal of Nutrition 112 203-213, 2014
    DOI:10.1017/S0007114514000737
    View abstract

    Wightman EL, Reay JL, Haskell CF, Williamson G, Dew TP, Kennedy DO Effects of resveratrol alone or in combination with piperine on cerebral blood flow parameters and cognitive performance in human subjects: a randomised, double-blind, placebo-controlled, cross-over investigation. Br J Nutr 112 203-213, 2014
    DOI:10.1017/S0007114514000737
    View abstract

    Pimpão RC, Dew T, Figueira ME, Mcdougall GJ, Stewart D, Ferreira RB, Santos CN, Williamson G Urinary metabolite profiling identifies novel colonic metabolites and conjugates of phenolics in healthy volunteers Molecular Nutrition and Food Research 58 1414-1425, 2014
    DOI:10.1002/mnfr.201300822
    View abstract

    Nagy K, Lobo B, Courtet-Compondu M-C, Braga-Lagache S, Ramos L, Puig-Divi V, Azpiroz F, Malagelada JR, Beaumont M, Moulin J, Acquistapacea S, Sagalowicz L, Kussmann M, Santos J, Holst B, Williamson G Vitamin E and vitamin E acetate absorption from self-assembly systems under pancreas insufficiency conditions CHIMIA 68 129-134, 2014
    DOI:10.2533/chimia.2014.129
    View abstract

    Jailani F, Williamson G Effect of edible oils on quercetin, kaempferol and galangin transport and conjugation in the intestinal Caco-2/HT29-MTX co-culture model Food and Function 5 653-662, 2014
    DOI:10.1039/c3fo60691k
    View abstract

    Renouf M, Marmet C, Giuffrida F, Lepage M, Barron D, Beaumont M, Williamson G, Dionisi F Dose-response plasma appearance of coffee chlorogenic and phenolic acids in adults. Molecular Nutrition and Food Research 58 301-309, 2014
    DOI:10.1002/mnfr.201300349
    View abstract

    Stellingwerff T, Godin JP, Chou CJ, Grathwohl D, Ross AB, Cooper KA, Williamson G, Actis-Goretta L The effect of acute dark chocolate consumption on carbohydrate metabolism and performance during rest and exercise. Applied Physiology, Nutrition, and Metabolism 39 173-182, 2014
    DOI:10.1139/apnm-2013-0152
    View abstract

    Erk T, Renouf M, Williamson G, Melcher R, Steiling H, Richling E Absorption and isomerization of caffeoylquinic acids from different foods using ileostomist volunteers European Journal of Nutrition 53 159-166, 2014
    DOI:10.1007/s00394-013-0512-z
    View abstract

    Erk T, Hauser J, Williamson G, Renouf M, Steiling H, Dionisi F, Richling E Structure- and dose-absorption relationships of coffee polyphenols BioFactors 40 103-112, 2014
    DOI:10.1002/biof.1101
    View abstract

    Stalmach A, Williamson G, Crozier A Impact of dose on the bioavailability of coffee chlorogenic acids in humans Food and Function 5 1727-1737, 2014
    DOI:10.1039/c4fo00316k
    View abstract

    Dew TP, Wang G, Williamson G Urinary excretion of ginkgolide terpene lactones following acute consumption of Ginkgo biloba extract. Biofactors -, 2013
    DOI:10.1002/biof.1151
    View abstract

    Wong CC, Williamson G Inhibition of hydroxycinnamic acid sulfation by flavonoids and their conjugated metabolites BioFactors 39 644-651, 2013
    DOI:10.1002/biof.1127
    View abstract

    Dew TP, Williamson G Controlled flax interventions for the improvement of menopausal symptoms and postmenopausal bone health: a systematic review. Menopause 20 1207-1215, 2013
    DOI:10.1097/GME.0b013e3182896ae5
    View abstract

    Actis-Goretta L, Lévèques A, Rein M, Teml A, Schäfer C, Hofmann U, Li H, Schwab M, Eichelbaum M, Williamson G Intestinal absorption, metabolism, and excretion of (-)-epicatechin in healthy humans assessed by using an intestinal perfusion technique. Am J Clin Nutr 98 924-933, 2013
    DOI:10.3945/ajcn.113.065789
    View abstract

    Rhodes LE, Darby G, Farrar MD, Bennett S, Watson REB, Massey KA, Nicolaou A, Clarke KA, Dew TP, Williamson G Oral green tea catechin metabolites are incorporated into human skin and protect against UV radiation-induced cutaneous inflammation in association with reduced production of pro-inflammatory eicosanoid 12-hydroxyeicosatetraenoic acid British Journal of Nutrition 110 891-900, 2013
    DOI:10.1017/S0007114512006071
    View abstract

    Farrell TL, Ellam SL, Forrelli T, Williamson G Attenuation of glucose transport across Caco-2 cell monolayers by a polyphenol-rich herbal extract: Interactions with SGLT1 and GLUT2 transporters BioFactors 39 448-456, 2013
    DOI:10.1002/biof.1090
    View abstract

    Farrell TL, Ellam SL, Forrelli T, Williamson G Attenuation of glucose transport across Caco-2 cell monolayers by a polyphenol-rich herbal extract: interactions with SGLT1 and GLUT2 transporters. Biofactors 39 448-456, 2013
    DOI:10.1002/biof.1090
    View abstract

    Pimpão RC, Dew T, Oliveira PB, Williamson G, Ferreira RB, Santos CN Analysis of phenolic compounds in portuguese wild and commercial berries after multienzyme hydrolysis Journal of Agricultural and Food Chemistry 61 4053-4062, 2013
    DOI:10.1021/jf305498j
    View abstract

    Pandino G, Lombardo S, Williamson G, Mauromicale G Flavonoids content of cynara cardunculus l. wild and cultivated germplasm accessions Acta Horticulturae 983 81-86, 2013
    View abstract

    Nagy K, Ramos L, Courtet-Compondu MC, Braga-Lagache S, Redeuil K, Lobo B, Azpiroz F, Malagelada JR, Beaumont M, Moulin J, Acquistapache S, Sagalowicz L, Kussmann M, Santos J, Holst B, Williamson G Double-balloon jejunal perfusion to compare absorption of vitamin E and vitamin E acetate in healthy volunteers under maldigestion conditions European Journal of Clinical Nutrition 67 202-206, 2013
    DOI:10.1038/ejcn.2012.183
    View abstract

    Nagy K, Ramos L, Courtet-Compondu M-C, Braga-Lagache S, Redeuil K, Lobo B, Azpiroz F, Malagelada J-R, Beaumont M, Moulin J, Acquistapache S, Sagalowicz L, Kussmann M, Santos J, Holst B, Williamson G Double-balloon jejunal perfusion to compare absorption of vitamin E and vitamin E acetate in healthy volunteers under maldigestion conditions. Eur J Clin Nutr 67 202-206, 2013
    DOI:10.1038/ejcn.2012.183
    View abstract

    Renouf M, Marmet C, Guy PA, Beaumont M, Lepage M, Dionisi F, Williamson G Dose-response plasma appearance of green tea catechins in adults Molecular Nutrition and Food Research -, 2013
    DOI:10.1002/mnfr.201200512
    View abstract

    Williamson G Possible effects of dietary polyphenols on sugar absorption and digestion Molecular Nutrition and Food Research 57 48-57, 2013
    DOI:10.1002/mnfr.201200511
    View abstract

    Williamson G Possible effects of dietary polyphenols on sugar absorption and digestion. Mol Nutr Food Res 57 48-57, 2013
    DOI:10.1002/mnfr.201200511
    View abstract

    O'Leary KA, de Pascual-Teresa S, Needs PW, Bao Y-P, Williamson G, O'Brien NM Corrigendum to "Effect of flavonoids and Vitamin E on cyclooxygenase-2 (COX-2) transcription" [Mutat. Res. 551 (1-2) (July 2004) 245-254] (DOI:10.1016/j.mrfmmm.2004.01.015) Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis -, 2013
    DOI:10.1016/j.mrfmmm.2013.08.007

    Ellam S, Williamson G Cocoa and human health. Annu Rev Nutr 33 105-128, 2013
    DOI:10.1146/annurev-nutr-071811-150642
    View abstract

    Carughi A, Murphy D, Williamson G Polyphenols from Raisins Have Similar Bioavailability to those from Grapes and White Wine: A Human Intervention Study ANNALS OF NUTRITION AND METABOLISM 62 14-14, 2013

    O'Leary KA, de Pascual-Teresa S, Needs PW, Bao YP, O'Brien NM, Williamson G Corrigendum to "Effect of flavonoids and Vitamin E on cyclooxygenase-2 (COX-2) transcription" [Mutat. Res. 551 (1-2) (July 2004) 245-254] Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis 749 92-, 2013
    DOI:10.1016/j.mrfmmm.2013.08.007

    News from the Food&Function Editors Food Funct. 4 9-9, 2013
    DOI:10.1039/C2FO90040H

    Erk T, Williamson G, Renouf M, Marmet C, Steiling H, Dionisi F, Barron D, Melcher R, Richling E Dose-dependent absorption of chlorogenic acids in the small intestine assessed by coffee consumption in ileostomists Molecular Nutrition and Food Research 56 1488-1500, 2012
    DOI:10.1002/mnfr.201200222
    View abstract

    Farrell TL, Gomez-Juaristi M, Poquet L, Redeuil K, Nagy K, Renouf M, Williamson G Absorption of dimethoxycinnamic acid derivatives in vitro and pharmacokinetic profile in human plasma following coffee consumption. Mol Nutr Food Res 56 1413-1423, 2012
    DOI:10.1002/mnfr.201200021
    View abstract

    Actis-Goretta L, Lévèques A, Giuffrida F, Romanov-Michailidis F, Viton F, Barron D, Duenas-Paton M, Gonzalez-Manzano S, Santos-Buelga C, Williamson G, Dionisi F Elucidation of (-)-epicatechin metabolites after ingestion of chocolate by healthy humans Free Radical Biology and Medicine 53 787-795, 2012
    DOI:10.1016/j.freeradbiomed.2012.05.023
    View abstract

    Wong CC, Akiyama Y, Abe T, Lippiat JD, Orfila C, Williamson G Carrier-mediated transport of quercetin conjugates: involvement of organic anion transporters and organic anion transporting polypeptides. Biochem Pharmacol 84 564-570, 2012
    DOI:10.1016/j.bcp.2012.05.011
    View abstract

    Pandino G, Lombardo S, Williamson G, Mauromicale G Polyphenol profile and content in wild and cultivated Cynara cardunculus L Italian Journal of Agronomy 7 254-261, 2012
    DOI:10.4081/ija.2012.e35
    View abstract

    Romanov-Michailidis F, Viton F, Fumeaux R, Lévèques A, Actis-Goretta L, Rein M, Williamson G, Barron D Epicatechin B-ring conjugates: first enantioselective synthesis and evidence for their occurrence in human biological fluids. Org Lett 14 3902-3905, 2012
    DOI:10.1021/ol3016463
    View abstract

    Williamson G Dietary Flavonoids, 2012
    DOI:10.1002/9781119946045.ch27
    View abstract

    Nagy K, Courtet-Compondu M-C, Williamson G, Rezzi S, Kussmann M, Rytz A Non-covalent binding of proteins to polyphenols correlates with their amino acid sequence FOOD CHEMISTRY 132 1333-1339, 2012
    DOI:10.1016/j.foodchem.2011.11.113

    Renouf M, Marmet C, Giuffrida F, Williamson G, Dionisi F Dose response bioavailability of coffee chlorogenic acids in humans FASEB JOURNAL 26 , 2012

    Actis-Goretta L, Leveques A, Renouf M, Rein M, Williamson G, Dionisi F Quantification of (-)-epicatechin metabolites after ingestion of flavanol-rich foods. FASEB JOURNAL 26 , 2012

    Sies H, Hollman PCH, Grune T, Stahl W, Biesalski HK, Williamson G Protection by Flavanol-Rich Foods Against Vascular Dysfunction and Oxidative Damage: 27th Hohenheim Consensus Conference ADVANCES IN NUTRITION 3 217-221, 2012
    DOI:10.3945/an.111.001578

    Richling E, Williamson G, Renouf M, Steiling H, Dionisi F, Barron D, Scheppach W, Melcher R, Erk T Dose-response relationship of chlorogenic acids in humans NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY 385 , 2012

    Davison G, Callister R, Williamson G, Cooper KA, Gleeson M The effect of acute pre-exercise dark chocolate consumption on plasma antioxidant status, oxidative stress and immunoendocrine responses to prolonged exercise EUROPEAN JOURNAL OF NUTRITION 51 69-79, 2012
    DOI:10.1007/s00394-011-0193-4

    Farrell TL, Poquet L, Dew TP, Barber S, Williamson G Predicting phenolic acid absorption in Caco-2 cells: a theoretical permeability model and mechanistic study. Drug Metab Dispos 40 397-406, 2012
    DOI:10.1124/dmd.111.041665
    View abstract

    Lévèques A, Actis-Goretta L, Rein MJ, Williamson G, Dionisi F, Giuffrida F UPLC-MS/MS quantification of total hesperetin and hesperetin enantiomers in biological matrices. J Pharm Biomed Anal 57 1-6, 2012
    DOI:10.1016/j.jpba.2011.08.031
    View abstract

    Pandino G, Lombardo S, Mauromicale G, Williamson G Characterization of phenolic acids and flavonoids in leaves, stems, bracts and edible parts of globe artichokes Acta Horticulturae 942 413-418, 2012
    View abstract

    Williamson G, Stalmach A Absorption and Metabolism of Dietary Chlorogenic Acids and Procyanidins RECENT ADVANCES IN POLYPHENOL RESEARCH, VOL 3 3 , 2012

    New Editors in food structure and functionality Food&Function 3 689-689, 2012
    DOI:10.1039/c2fo90019j

    Raheem KS, Botting NP, Williamson G, Barron D Total synthesis of 3,5-O-dicaffeoylquinic acid and its derivatives TETRAHEDRON LETTERS 52 7175-7177, 2011
    DOI:10.1016/j.tetlet.2011.10.127

    Vargas-Murga L, Garcia-Alvarez A, Roman-Vinas B, Ngo J, Ribas-Barba L, van den Berg SJPL, Williamson G, Serra-Majem L Plant food supplement (PFS) market structure in EC Member States, methods and techniques for the assessment of individual PFS intake FOOD&FUNCTION 2 731-739, 2011
    DOI:10.1039/c1fo10075k

    Brand W, Oosterhuis B, Krajcsi P, Barron D, Dionisi F, van Bladeren PJ, Rietjens IMCM, Williamson G Interaction of hesperetin glucuronide conjugates with human BCRP, MRP2 and MRP3 as detected in membrane vesicles of overexpressing baculovirus-infected Sf9 cells BIOPHARMACEUTICS&DRUG DISPOSITION 32 530-535, 2011
    DOI:10.1002/bdd.780

    Williamson G, Coppens P, Serra-Majem L, Dew T Review of the efficacy of green tea, isoflavones and aloe vera supplements based on randomised controlled trials. Food Funct 2 753-759, 2011
    DOI:10.1039/c1fo10101c
    View abstract

    Farrell TL, Dew TP, Poquet L, Hanson P, Williamson G Absorption and metabolism of chlorogenic acids in cultured gastric epithelial monolayers. Drug Metab Dispos 39 2338-2346, 2011
    DOI:10.1124/dmd.111.040147
    View abstract

    Stalmach A, Crozier A, Clifford MN, Williamson G Phytochemicals in Coffee and the Bioavailability of Chlorogenic Acids, 2011
    DOI:10.1002/9781444347098.ch5

    Williamson G Coffee and Health, 2011
    DOI:10.1002/9781444347098.ch6

    Renouf M, Redeuil K, Longet K, Marmet C, Dionisi F, Kussmann M, Williamson G, Nagy K Plasma pharmacokinetics of catechin metabolite 4'-O-Me-EGC in healthy humans. Eur J Nutr 50 575-580, 2011
    DOI:10.1007/s00394-010-0164-1
    View abstract

    Darby G, Dew T, Massey K, Clarke K, Bennett S, Watson R, Nicolaou A, Williamson G, Rhodes L Green tea catechins reduce UVR-upregulation of the pro-inflammatory lipoxygenase metabolite 12-HETE in human skin JOURNAL OF INVESTIGATIVE DERMATOLOGY 131 , 2011

    Redeuil K, Smarrito-Menozzi C, Guy P, Rezzi S, Dionisi F, Williamson G, Nagy K, Renouf M Identification of novel circulating coffee metabolites in human plasma by liquid chromatography-mass spectrometry J CHROMATOGR A 1218 4678-4688, 2011
    DOI:10.1016/j.chroma.2011.05.050

    Farrell T, Poquet L, Dionisi F, Barron D, Williamson G Characterization of hydroxycinnamic acid glucuronide and sulfate conjugates by HPLC-DAD-MS(2): enhancing chromatographic quantification and application in Caco-2 cell metabolism. J Pharm Biomed Anal 55 1245-1254, 2011
    DOI:10.1016/j.jpba.2011.03.023
    View abstract

    Wong CC, Barron D, Orfila C, Dionisi F, Krajcsi P, Williamson G Interaction of hydroxycinnamic acids and their conjugates with organic anion transporters and ATP-binding cassette transporters. Mol Nutr Food Res 55 979-988, 2011
    DOI:10.1002/mnfr.201000652
    View abstract

    Williamson G, Dionisi F, Renouf M Flavanols from green tea and phenolic acids from coffee: critical quantitative evaluation of the pharmacokinetic data in humans after consumption of single doses of beverages. Mol Nutr Food Res 55 864-873, 2011
    DOI:10.1002/mnfr.201000631
    View abstract

    Ross AB, Vuong LT, Ruckle J, Synal HA, Schulze-König T, Wertz K, Rümbeli R, Liberman RG, Skipper PL, Tannenbaum SR, Bourgeois A, Guy PA, Enslen M, Nielsen ILF, Kochhar S, Richelle M, Fay LB, Williamson G Lycopene bioavailability and metabolism in humans: an accelerator mass spectrometry study. Am J Clin Nutr 93 1263-1273, 2011
    DOI:10.3945/ajcn.110.008375
    View abstract

    Menozzi-Smarrito C, Wong CC, Meinl W, Glatt H, Fumeaux R, Munari C, Robert F, Williamson G, Barron D First Chemical Synthesis and in Vitro Characterization of the Potential Human Metabolites 5-O-Feruloylquinic Acid 4 '-Sulfate and 4 '-O-Glucuronide J AGR FOOD CHEM 59 5671-5676, 2011
    DOI:10.1021/jf200272m

    Pandino G, Lombardo S, Mauromicale G, Williamson G Phenolic acids and flavonoids in leaf and floral stem of cultivated and wild Cynara cardunculus L. genotypes FOOD CHEM 126 417-422, 2011
    DOI:10.1016/j.foodchem.2010.11.001

    Wong CC, Botting NP, Orfila C, Al-Maharik N, Williamson G Flavonoid conjugates interact with organic anion transporters (OATs) and attenuate cytotoxicity of adefovir mediated by organic anion transporter 1 (OAT1/SLC22A6). Biochem Pharmacol 81 942-949, 2011
    DOI:10.1016/j.bcp.2011.01.004
    View abstract

    Allgrove J, Farrell E, Gleeson M, Williamson G, Cooper K Regular Dark Chocolate Consumption's Reduction of Oxidative Stress and Increase of Free-Fatty-Acid Mobilization in Response to Prolonged Cycling INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM 21 113-123, 2011

    Renouf M, Marmet C, Giuffrida F, Williamson G, Dionisi F Bioavailability and metabolism of coffee chlorogenic acids in humans FASEB JOURNAL 25 , 2011

    Naz S, Siddiqi R, Dew TP, Williamson G Epigallocatechin-3-gallate Inhibits Lactase but Is Alleviated by Salivary Proline-Rich Proteins J AGR FOOD CHEM 59 2734-2738, 2011
    DOI:10.1021/jf103072z

    Pandino G, Lombardo S, Mauromicale G, Williamson G Profile of polyphenols and phenolic acids in bracts and receptacles of globe artichoke (Cynara cardunculus var. scolymus) germplasm J FOOD COMPOS ANAL 24 148-153, 2011
    DOI:10.1016/j.jfca.2010.04.010

    Remond D, Buffiere C, Pouyet C, Papet I, Dardevet D, Savary-Auzeloux I, Williamson G, Faure M, Breuille D Cysteine fluxes across the portal-drained viscera of enterally fed minipigs: effect of an acute intestinal inflammation AMINO ACIDS 40 543-552, 2011
    DOI:10.1007/s00726-010-0672-6

    Nagy K, Redeuil K, Williamson G, Rezzi S, Dionisi F, Longet K, Destaillats F, Renouf M First identification of dimethoxycinnamic acids in human plasma after coffee intake by liquid chromatography-mass spectrometry. J Chromatogr A 1218 491-497, 2011
    DOI:10.1016/j.chroma.2010.11.076
    View abstract

    Davison G, Callister R, Williamson G, Cooper KA, Gleeson M The effect of acute pre-exercise dark chocolate consumption on plasma antioxidant status, oxidative stress and immunoendocrine responses to prolonged exercise European Journal of Nutrition 1-11, 2011

    Looking to the year ahead for Food&Function Food Funct. 2 9-10, 2011
    DOI:10.1039/C0FO90016H

    Renouf M, Guy P, Marmet C, Longet K, Fraering A-L, Moulin J, Barron D, Dionisi F, Cavin C, Steiling H, Williamson G Plasma appearance and correlation between coffee and green tea metabolites in human subjects. Br J Nutr 104 1635-1640, 2010
    DOI:10.1017/S0007114510002709
    View abstract

    Manzano S, Williamson G Polyphenols and phenolic acids from strawberry and apple decrease glucose uptake and transport by human intestinal Caco-2 cells. Mol Nutr Food Res 54 1773-1780, 2010
    DOI:10.1002/mnfr.201000019
    View abstract

    Stoupi S, Williamson G, Drynan JW, Barron D, Clifford MN A comparison of the in vitro biotransformation of (-)-epicatechin and procyanidin B2 by human faecal microbiota Mol.Nutr.Food Res. epub in press -, 2010
    DOI:10.1002/mnfr.200900123
    View abstract

    Renouf M, Guy PA, Marmet C, Fraering AL, Longet K, Moulin J, Enslen M, Barron D, Dionisi F, Cavin C, Williamson G, Steiling H Measurement of caffeic and ferulic acid equivalents in plasma after coffee consumption: Small intestine and colon are key sites for coffee metabolism Mol.Nutr.Food Res. epub in press -, 2010
    DOI:10.1002/mnfr.200900056
    View abstract

    Stalmach A, Mullen W, Steiling H, Williamson G, Lean ME, Crozier A Absorption, metabolism, and excretion of green tea flavan-3-ols in humans with an ileostomy Mol.Nutr.Food Res. epub in press -, 2010
    DOI:10.1002/mnfr.200900194
    View abstract

    Fumeaux R, Menozzi-Smarrito C, Stalmach A, Munari C, Kraehenbuehl K, Steiling H, Crozier A, Williamson G, Barron D First synthesis, characterization, and evidence for the presence of hydroxycinnamic acid sulfate and glucuronide conjugates in human biological fluids as a result of coffee consumption. Org Biomol Chem 8 5199-5211, 2010
    DOI:10.1039/c0ob00137f
    View abstract

    Wong CC, Meinl W, Glatt H-R, Barron D, Stalmach A, Steiling H, Crozier A, Williamson G In vitro and in vivo conjugation of dietary hydroxycinnamic acids by UDP-glucuronosyltransferases and sulfotransferases in humans. J Nutr Biochem 21 1060-1068, 2010
    DOI:10.1016/j.jnutbio.2009.09.001
    View abstract

    Perez-Jimenez J, Hubert J, Hooper L, Cassidy A, Manach C, Williamson G, Scalbert A Urinary metabolites as biomarkers of polyphenol intake in humans: a systematic review AM J CLIN NUTR 92 801-809, 2010
    DOI:10.3945/ajcn.2010.29924

    Williamson G, Clifford MN Colonic metabolites of berry polyphenols: the missing link to biological activity? Br J Nutr 104 Suppl 3 S48-S66, 2010
    DOI:10.1017/S0007114510003946
    View abstract

    Williamson G, Day A The 4th International Conference on Polyphenols and Health (ICPH2009). Arch Biochem Biophys 501 1-, 2010
    DOI:10.1016/j.abb.2010.07.031

    Stoupi S, Williamson G, Drynan JW, Barron D, Clifford MN Procyanidin B2 catabolism by human fecal microflora: Partial characterization of 'dimeric' intermediates ARCH BIOCHEM BIOPHYS 501 73-78, 2010
    DOI:10.1016/j.abb.2010.02.009

    Stalmach A, Steiling H, Williamson G, Crozier A Bioavailability of chlorogenic acids following acute ingestion of coffee by humans with an ileostomy ARCH BIOCHEM BIOPHYS 501 98-105, 2010
    DOI:10.1016/j.abb.2010.03.005

    Williamson G, Carughi A Polyphenol content and health benefits of raisins. Nutr Res 30 511-519, 2010
    DOI:10.1016/j.nutres.2010.07.005
    View abstract

    Richelle M, Sanchez B, Tavazzi I, Lambelet P, Bortlik K, Williamson G Lycopene isomerisation takes place within enterocytes during absorption in human subjects. Br J Nutr 103 1800-1807, 2010
    DOI:10.1017/S0007114510000103
    View abstract

    Brand W, Shao J, Hoek-van den Hil EF, van Elkr KN, Spenkelink B, de Haan LHJ, Rein MJ, Dionisi F, Williamson G, van Bladeren PJ, Rietjens IMCM Stereoselective Conjugation, Transport and Bioactivity of S- and R-Hesperetin Enantiomers in Vitro J AGR FOOD CHEM 58 6119-6125, 2010
    DOI:10.1021/jf1008617

    Viton F, Landreau C, Rustidge D, Little G, Robert F, Williamson G, Barron D TOTAL SYNTHESIS OF C-14-LABELED PROCYANIDIN B2 JOURNAL OF LABELLED COMPOUNDS&RADIOPHARMACEUTICALS 53 , 2010

    Renouf M, Marmet C, Giuffrida F, Williamson G, Dionisi F Dose response bioavailability of coffee chlorogenic acids in humans FASEB JOURNAL 24 -, 2010

    Actis-Goretta L, Leveques A, Renouf M, Rein M, Williamson G, Dionisi F Quantification of (-)-epicatechin metabolites after ingestion of flavanol-rich foods FASEB JOURNAL 24 -, 2010

    Ellam SL, Williamson G Cocoa polyphenols inhibit sucrose hydrolysis in Caco-2 cells FASEB JOURNAL 24 -, 2010

    Raab T, Barron D, Vera FA, Crespy V, Oliveira M, Williamson G Catechin Glucosides: Occurrence, Synthesis, and Stability J AGR FOOD CHEM 58 2138-2149, 2010
    DOI:10.1021/jf9034095

    Renouf M, Marmet C, Guy P, Fraering AL, Longet K, Moulin J, Enslen M, Barron D, Cavin C, Dionisi F, Rezzi S, Kochhar S, Steiling H, Williamson G Nondairy creamer, but not milk, delays the appearance of coffee phenolic acid equivalents in human plasma J.Nutr. 140 259-263, 2010
    DOI:10.3945/jn.109.113027
    View abstract

    Stoupi S, Williamson G, Viton F, Barron D, King LJ, Brown JE, Clifford MN In vivo bioavailability, absorption, excretion, and pharmacokinetics of [14C]procyanidin B2 in male rats. Drug Metab Dispos 38 287-291, 2010
    DOI:10.1124/dmd.109.030304
    View abstract

    Brand W, Padilla B, van Bladeren PJ, Williamson G, Rietjens IM The effect of co-administered flavonoids on the metabolism of hesperetin and the disposition of its metabolites in Caco-2 cell monolayers Mol.Nutr.Food Res. epub -, 2010
    DOI:10.1002/mnfr.200900183
    View abstract

    Pandino G, Courts FL, Lombardo S, Mauromicale G, Williamson G Caffeoylquinic Acids and Flavonoids in the Immature Inflorescence of Globe Artichoke, Wild Cardoon, and Cultivated Cardoon J AGR FOOD CHEM 58 1026-1031, 2010
    DOI:10.1021/jf903311j

    Bredsdorff L, Nielsen IL, Rasmussen SE, Cornett C, Barron D, Bouisset F, Offord E, Williamson G Absorption, conjugation and excretion of the flavanones, naringenin and hesperetin from alpha-rhamnosidase-treated orange juice in human subjects Br.J.Nutr. epub 1-8, 2010
    DOI:10.1017/S0007114509993679
    View abstract

    Brand W, Boersma MG, Bik H, Hoek-van den Hil EF, Vervoort J, Barron D, Meinl W, Glatt H, Williamson G, van Bladeren PJ, Rietjens IM Phase II metabolism of hesperetin by individual UDP-glucuronosyltransferases (UGTs) and sulfotransferases (SULTs) and rat and human tissue samples Drug Metab Dispos. epub -, 2010
    DOI:10.1124/dmd.109.031047
    View abstract

    Folmer BM, Barron D, Hughes E, Miguet L, Sanchez B, Heudi O, Rouvet M, Sagalowicz L, Callier P, Michel M, Williamson G Monocomponent hexa- and dodecaethylene glycol succinyl-tocopherol esters: Self-assembly structures, cellular uptake and sensitivity to enzyme hydrolysis BIOCHEM PHARMACOL 78 1464-1474, 2009
    DOI:10.1016/j.bcp.2009.07.009

    Williamson G, Sies H, Heber D, Keen CL, Macdonald IA, Actis-Goretta L, Momma TY, Ottaviani JI, Holt RR, Schroeter H, Heiss C Functional foods for health promotion: state-of-the-science on dietary flavonoids. Extended abstracts from the 12th Annual Conference on Functional Foods for Health Promotion, April 2009. Nutr Rev 67 736-743, 2009
    DOI:10.1111/j.1753-4887.2009.00257.x
    View abstract

    Guy PA, Renouf M, Barron D, Cavin C, Dionisi F, Kochhar S, Rezzi S, Williamson G, Steiling H Quantitative analysis of plasma caffeic and ferulic acid equivalents by liquid chromatography tandem mass spectrometry J.Chromatogr.B 877 3965-3974, 2009
    DOI:10.1016/j.jchromb.2009.10.006
    View abstract

    Poquet L, Clifford MN, Williamson G Bioavailability of Flavanols and Phenolic Acids, 2009
    DOI:10.1002/9780470531792.ch2

    Habauzit V, Nielsen IL, Gil-Izquierdo A, Trzeciakiewicz A, Morand C, Chee W, Barron D, Lebecque P, Davicco MJ, Williamson G, Offord E, Coxam V, Horcajada MN Increased bioavailability of hesperetin-7-glucoside compared with hesperidin results in more efficient prevention of bone loss in adult ovariectomised rats Br.J.Nutr. 102 976-984, 2009
    DOI:10.1017/S0007114509338830
    View abstract

    Courts FL, Williamson G The C-glycosyl flavonoid, aspalathin, is absorbed, methylated and glucuronidated intact in humans. Mol Nutr Food Res 53 1104-1111, 2009
    DOI:10.1002/mnfr.200800569
    View abstract

    Boumendjel A, Blanc M, Williamson G, Barron D Efficient Synthesis of Flavanone Glucuronides Journal of Agricultural and Food Chemistry 57 7264-7267, 2009
    View abstract

    Stalmach A, Mullen W, Barron D, Uchida K, Yokota T, Cavin C, Steiling H, Williamson G, Crozier A Metabolite profiling of hydroxycinnamate derivatives in plasma and urine after the ingestion of coffee by humans: identification of biomarkers of coffee consumption Drug Metab Dispos. 37 1749-1758, 2009
    DOI:10.1124/dmd.109.028019
    View abstract

    Landreau C, Rustidge D, Viton F, Robert F, Williamson G, Barron D Total Synthesis of C-14-Labelled Procyanidin B2 Journal of Labelled Compounds&Radiopharmaceuticals 52 213-213, 2009

    Brand W, Shao J, Rein MJ, Barron D, Williamson G, Van Bladeren PJ, Rietjens IMCM Stereoselective Kinetics of R- and S-Enantiomers of the Citrus Flavonoid Hesperetin In Vitro DRUG METABOLISM REVIEWS 41 , 2009

    Renouf M, Marmet C, Guy P, Fraering A-L, Moulin J, Enslen M, Cavin C, Barron D, Dionisi F, Williamson G, Steiling H Effect of milk and non dairy creamer on human bioavailability of coffee phenolic acids FASEB JOURNAL 23 -, 2009

    Remond D, Buffiere C, Godin JP, Mirand PP, Obled C, Papet I, Dardevet D, Williamson G, Breuille D, Faure M Intestinal inflammation increases gastrointestinal threonine uptake and mucin synthesis in enterally fed minipigs J Nutr. 139 720-726, 2009
    View abstract

    Williamson G Bioavailability and health effects of cocoa polyphenols. Inflammopharmacology 17 111-, 2009
    DOI:10.1007/s10787-008-8030-y

    Wong CC, Glatt H, Barron D, Stalmach A, Crozier A, Steiling H, Williamson G Conjugation of hydroxycinnamic acids by human UDP-glucuronosyltransferases and sulfotransferase in vitro and in vivo ABSTR PAP AM CHEM S 237 34-34, 2009

    Godin JP, Mermoud AF, Remond D, Faure M, Breuille D, Williamson G, Pere-Trepat E, Ramadan Z, Fay LB, Kochhar S Simultaneous measurement of (13)C- and (15)N-isotopic enrichments of threonine by mass spectrometry Rapid Commun.Mass Spectrom. 23 1109-1115, 2009
    View abstract

    Williamson G DIETARY FLAVONOIDS AND THE RISK OF CANCER IUBMB LIFE 61 286-286, 2009

    Barrington R, Williamson G, Bennett RN, Davis BD, Brodbelt JS, Kroon PA Absorption, Conjugation and Efflux of the Flavonoids, Kaempferol and Galangin, Using the Intestinal CACO-2/TC7 Cell Model J.Funct.Foods 1 74-87, 2009
    DOI:10.1016/j.jff.2008.09.011
    View abstract

    Viton F, Landreau C, Rustidge D, Robert F, Williamson G, Barron D First Total Synthesis of C-14-Labeled Procyanidin B2-A Milestone Toward Understanding Cocoa Polyphenol Metabolism European Journal of Organic Chemistry 6069-6078, 2008
    View abstract

    Brand W, van der Wel PA, Rein MJ, Barron D, Williamson G, van Bladeren PJ, Rietjens IM Metabolism and transport of the citrus flavonoid hesperetin in Caco-2 cell monolayers Drug Metab Dispos. 36 1794-1802, 2008
    View abstract

    Poquet L, Clifford MN, Williamson G Effect of dihydrocaffeic acid on UV irradiation of human keratinocyte HaCaT cells Arch.Biochem.Biophys. 476 196-204, 2008
    View abstract

    Lo PE, Scheib H, Frei N, Williamson G, Grigorov M, Chou CJ Flavonoids for controlling starch digestion: structural requirements for inhibiting human alpha-amylase J Med.Chem. 51 3555-3561, 2008
    View abstract

    Williamson G, Holst B Dietary reference intake (DRI) value for dietary polyphenols: are we heading in the right direction? BRITISH JOURNAL OF NUTRITION 99 , 2008
    DOI:10.1017/S0007114508006867

    Holst B, Williamson G Nutrients and phytochemicals: from bioavailability to bioefficacy beyond antioxidants CURR OPIN BIOTECH 19 73-82, 2008
    DOI:10.1016/j.copbio.2008.03.003

    Seefelder W, Varga N, Studer A, Williamson G, Scanlan FP, Stadler RH Esters of 3-chloro-1,2-propanediol (3-MCPD) in vegetable oils: Significance in the formation of 3-MCPD Food Addit.Contam 25 391-400, 2008
    View abstract

    Poquet L, Clifford MN, Williamson G Investigation of the metabolic fate of dihydrocaffeic acid Biochem.Pharmacol. 75 1218-1229, 2008
    View abstract

    Williamson G A Brief Review of the Impact of Dietary Polyphenols on Cardiovascular Disease In Nutrition and Health , 2008
    DOI:10.1002/9780470690611.ch3

    Cooper KA, Campos-Gimenez E, Jimenez AD, Rytz A, Nagy K, Williamson G Predictive Relationship between Polyphenol and Nonfat Cocoa Solids Content of Chocolate J.Agric.Food Chem. 56 260-265, 2008
    View abstract

    Poquet L, Clifford MN, Williamson G Transport and metabolism of ferulic acid through the colonic epithelium Drug Metab Dispos. 36 190-197, 2008
    View abstract

    Cooper KA, Donovan JL, Waterhouse AL, Williamson G Cocoa and health: a decade of research Br.J.Nutr. 99 1-11, 2008
    View abstract

    Brand W, van der Wel PAI, Williamson G, van Bladeren PJ, Rietjens IMCM Modulating hesperetin bioavailability at the level of its intestinal metabolism and ABC transporter mediated efflux studied in Caco-2 monolayers TOXICOLOGY LETTERS 172 S101-S101, 2007
    DOI:10.1016/j.toxlet.2007.05.276

    Steiling H, Longet K, Moodycliffe A, Mansourian R, Bertschy E, Smola H, Mauch C, Williamson G Sodium-dependent vitamin C transporter isoforms in skin: Distribution, kinetics, and effect of UVB-induced oxidative stress Free Radic.Biol.Med. 43 752-762, 2007
    View abstract

    Brand W, van der Wel PAI, Williamson G, van Bladeren PJ, Rietjens IMCM Modulating hesperetin bioavailability at the level of its intestinal metabolism and ABC transporter mediated efflux studied in Caco-2 monolayers CHEMICO-BIOLOGICAL INTERACTIONS 169 , 2007
    DOI:10.1016/j.cbi.2007.06.006

    Mutch DM, Klocke B, Morrison P, Murray CA, Henderson CJ, Seifert M, Williamson G The Disruption of Hepatic Cytochrome P450 Reductase Alters Mouse Lipid Metabolism J.Proteome.Res. 6 3976-3984, 2007
    View abstract

    Williamson G, Aeberli I, Miguet L, Zhang Z, Sanchez MB, Crespy V, Barron D, Needs P, Kroon PA, Glavinas H, Krajcsi P, Grigorov M Interaction of Positional Isomers of Quercetin Glucuronides with the Transporter ABCC2 (cMOAT, MRP2) Drug Metab Dispos. 35 1262-1268, 2007
    View abstract

    Clifford MN, Lopez V, Poquet L, Williamson G, Kuhnert N A systematic study of carboxylic acids in negative ion mode electrospray ionisation mass spectrometry providing a structural model for ion suppression Rapid Commun.Mass Spectrom. 21 2014-2018, 2007
    View abstract

    Scholz S, Williamson G Interactions affecting the Bioavailability of dietary polyphenols in vivo International Journal for Vitamin and Nutrition Research 77 224-235, 2007
    View abstract

    Cooper KA, Campos-Gimenez E, Jimenez AD, Nagy K, Donovan JL, Williamson G Rapid reversed phase ultra-performance liquid chromatography analysis of the major cocoa polyphenols and inter-relationships of their concentrations in chocolate J.Agric.Food Chem. 55 2841-2847, 2007
    View abstract

    Erdman JW, Balentine D, Arab L, Beecher G, Dwyer JT, Folts J, Harnly J, Hollman P, Keen CL, Mazza G, Messina M, Scalbert A, Vita J, Williamson G, Burrowes J Flavonoids and Heart Health: Proceedings of the ILSI North America Flavonoids Workshop, May 31-June 1, 2005, Washington, DC J.Nutr. 137 718S-737S, 2007
    View abstract

    Nielsen IL, Williamson G Review: review of the factors affecting bioavailability of soy isoflavones in humans Nutr.Cancer 57 1-10, 2007
    View abstract

    Habauzit V, Gil-Izquierdo A, Nielsen I-L, Morand C, Williamson G, Offord E, Lebecque P, Davicco M-J, Coxam V, Horcajada M-N Comparative effect of hesperidin (flavonoid of citrus fruit) and its metabolite hesperetin-7-glucoside on bone metabolism in adult rats ANNALS OF NUTRITION AND METABOLISM 51 204-204, 2007

    Mutch DM, Crespy V, Clough J, Henderson CJ, Lariani S, Mansourian R, Moulin J, Wolf CR, Williamson G Hepatic cytochrome p450 reductase-null mice show reduced transcriptional response to quercetin and reveal physiological homeostasis between jejunum and liver ANNALS OF NUTRITION AND METABOLISM 51 383-383, 2007

    Donovan JL, Crespy V, Oliveria M, Cooper KA, Gibson BB, Williamson G (+)-catechin is more bioavailable than (-)-catechin: Relevance to the bioavailability of catechin from cocoa Free Radical Research 40 1029-1034, 2006
    View abstract

    Brand W, Schutte ME, Williamson G, van Zanden JJ, Cnubben NH, Groten JP, van Bladeren PJ, Rietjens IM Flavonoid-mediated inhibition of intestinal ABC transporters may affect the oral bioavailability of drugs, food-borne toxic compounds and bioactive ingredients Biomed.Pharmacother. 60 508-519, 2006
    View abstract

    Richelle M, Sabatier M, Steiling H, Williamson G Skin bioavailability of dietary vitamin E, carotenoids, polyphenols, vitamin C, zinc and selenium Br.J.Nutr. 96 227-238, 2006
    View abstract

    Brand W, Williamson G, van Bladeren PJ, Rietjens IMCM Modulation and modelling of flavonoid bioavailability at the level of its intestinal metabolism and transport CHEMICO-BIOLOGICAL INTERACTIONS 161 165-165, 2006
    DOI:10.1016/j.cbi.2006.05.004

    Donnini S, Finetti F, Lusini L, Morbidelli L, Cheynier V, Barron D, Williamson G, Waltenberger J, Ziche M Divergent effects of quercetin conjugates on angiogenesis Br.J.Nutr. 95 1016-1023, 2006
    View abstract

    Horcajada MN, Habauzit V, Gil-Izquierdo A, Morand C, Williamson G, Barron D, Lebecque P, Davicco MJ, Offord E, Coxam V Hesperetine-7-glucose is more effective than hesperidine for improving bone metaholism in the adult rat ANNALES D ENDOCRINOLOGIE 67 , 2006

    Soon G, Quintin A, Scalfo F, Antille N, Williamson G, Offord E, Ginty F PIXImus Bone Densitometer and Associated Technical Measurement Issues of Skeletal Growth in the Young Rat Calcif.Tissue Int. 78 186-192, 2006
    View abstract

    Juge N, Nohr J, Gal-Coeffet MF, Kramhoft B, Furniss CS, Planchot V, Archer DB, Williamson G, Svensson B The activity of barley alpha-amylase on starch granules is enhanced by fusion of a starch binding domain from Aspergillus niger glucoamylase Biochim.Biophys.Acta 1764 275-284, 2006
    View abstract

    Cassidy A, Albertazzi P, Lise N, Hall W, Williamson G, Tetens I, Atkins S, Cross H, Manios Y, Wolk A, Steiner C, Branca F Critical review of health effects of soyabean phyto-oestrogens in post-menopausal women Proc.Nutr.Soc. 65 76-92, 2006
    View abstract

    Raab T, Bel.Rhlid R, Williamson G, Hansen CE, Chaillot D Enzymatic galloylation of catechins in room temperature ionic liquids Journal of Molecular Catalysis B: Enzymatic 44 60-65, 2006

    Affolter M, Bergonzelli GE, Blaser K, Blum-Sperisen S, Corthésy B, Fay LB, Garcia-Rodenas C, Lopes LV, Marvin-Guy L, Mercenier A, Mutch DM, Panchaud A, Raymond F, Schmidt-Weber C, Schumann A, Spertini F, Williamson G, Kussmann M -Omics for prevention: gene, protein and metabolite profiling to better understand individual disposition to disease. Nestle Nutr Workshop Ser Pediatr Program 57 247-250, 2006
    DOI:10.1159/000091077

    Steiling H, Longet K, Mansourian R, Bertschy E, Moodycliffe A, Mauch C, Williamson G Sodium-dependent vitamin C transporters - specific functions for the two transporter isoforms in skin FREE RADICAL RESEARCH 40 , 2006

    Mutch DM, Wahli W, Williamson G Nutrigenomics and nutrigenetics: the emerging faces of nutrition. FASEB J 19 1602-1616, 2005
    DOI:10.1096/fj.05-3911rev
    View abstract

    Adams EL, Kroon PA, Williamson G, Morris VJ AFM studies of water-soluble wheat arabinoxylans--effects of esterase treatment. Carbohydr Res 340 1841-1845, 2005
    DOI:10.1016/j.carres.2005.05.015
    View abstract

    Affolter M, Bergonzelli GE, Fay LB, Garcia-Rodenas C, Lopes LV, Marvin-Guy L, Mutch DM, Panchaud A, Raymond F, Schumann A, Williamson G, Kussmann M -Omics for food: Protein and gene expression profiling towards a better understanding of nutritional health JOURNAL OF BIOTECHNOLOGY 118 , 2005

    Kroon P, Williamson G Polyphenols: dietary components with established benefits to health? JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE 85 1239-1240, 2005
    DOI:10.1002/jsfa.2204

    Soon G, Ammann P, Williamson G, Ginty F, Offord E Lysine dose-response on microarchitecture of trabecular bone and gene expression of calcium transporters in growing rats BONE 36 , 2005

    Horcajada M, Morand C, Lebecque P, Puel C, Mathey J, Davicco M, Williamson G, Coxam V, Offord E Dose-response of hesperidin, a citrus flavonoid, on bone mass in young intact rats BONE 36 , 2005

    Quintin A, Nielsen I, Clough J, Moulin J, Lemaure B, Touche A, Courtois D, Horcajada M, Chee W, Williamson G, Offord E Effect of Carthamus tinctorius L. extracts on bone resorption in ovariectomized rats BONE 36 , 2005

    Anderle P, Sengstag T, Mutch DM, Rumbo M, Praz V, Mansourian R, Delorenzi M, Williamson G, Roberts MA Changes in the transcriptional profile of transporters in the intestine along the anterior-posterior and crypt-villus axes BMC GENOMICS 6 -, 2005
    DOI:10.1186/1471-2164-6-69

    Williamson G, Barron D, Shimoi K, Terao J In vitro biological properties of flavonoid conjugates found in vivo. Free Radic Res 39 457-469, 2005
    DOI:10.1080/10715760500053610
    View abstract

    Mutch DM, Grigorov M, Berger A, Fay LB, Roberts M-A, Watkins SM, Williamson G, German JB An integrative metabolism approach identifies stearoyl-CoA desaturase as a target for an arachidonate-enriched diet. FASEB J 19 599-601, 2005
    DOI:10.1096/fj.04-2674fje
    View abstract

    Furniss CSM, Williamson G, Kroon PA The substrate specificity and susceptibility to wheat inhibitor proteins of Penicillium funiculosum xylanases from a commercial enzyme preparation JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE 85 574-582, 2005
    DOI:10.1002/jsfa.1984

    Aura AM, Martin-Lopez P, O'Leary KA, Williamson G, Oksman-Caldentey KM, Poutanen K, Santos-Buelga C In vitro metabolism of anthocyanins by human gut microflora EUROPEAN JOURNAL OF NUTRITION 44 133-142, 2005
    DOI:10.1007/s00394-004-0502-2

    Morris VJ, Gunning AP, Faulds CB, Williamson G, Svensson B AFM images of complexes between amylose and Aspergillus niger glucoamylase mutants, native, and mutant starch binding domains: A model for the action of glucoamylase STARCH-STARKE 57 1-7, 2005
    DOI:10.1002/star.200400333

    Williamson G, Manach C Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studies AMERICAN JOURNAL OF CLINICAL NUTRITION 81 , 2005

    Manach C, Williamson G, Morand C, Scalbert A, Remesy C Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies AMERICAN JOURNAL OF CLINICAL NUTRITION 81 , 2005

    Williamson G, Manach C Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studies. Am J Clin Nutr 81 243S-255S, 2005
    View abstract

    Crespy V, Williamson G A review of the health effects of green tea catechins in in vivo animal models. J Nutr 134 3431S-3440S, 2004
    View abstract

    Crespy V, Williamson G A review of the health effects of green tea catechins in in vivo animal models JOURNAL OF NUTRITION 134 , 2004

    Crespy V, Williamson G A review of the health effects of green tea catechins in in vivo animal models Journal of Nutrition 134 -, 2004
    View abstract

    Tahir TA, Durand A, Gebruers K, Roussel A, Williamson G, Juge N Functional importance of Asp37 from a family 11 xylanase in the binding to two proteinaceous xylanase inhibitors from wheat. FEMS Microbiol Lett 239 9-15, 2004
    DOI:10.1016/j.femsle.2004.07.051
    View abstract

    Gunning AP, Kirby AR, Mackie AR, Kroon P, Williamson G, Morris VJ Watching molecular processes with the atomic force microscope: dynamics of polymer adsorption and desorption at the single molecule level. J Microsc 216 52-56, 2004
    DOI:10.1111/j.0022-2720.2004.01391.x
    View abstract

    Mutch DM, Simmering R, Donnicola D, Fotopoulos G, Holzwarth JA, Williamson G, Corthésy-Theulaz I Impact of commensal microbiota on murine gastrointestinal tract gene ontologies. Physiol Genomics 19 22-31, 2004
    DOI:10.1152/physiolgenomics.00105.2004
    View abstract

    Mutch DM, Simmering R, Donnicola D, Fotopoulos G, Holzwarth JA, Williamson G, Corthesy-Theulaz I Impact of commensal microbiota on murine gastrointestinal tract gene ontologies PHYSIOLOGICAL GENOMICS 19 22-31, 2004
    DOI:10.1152/physiolgenomics.00105.2004.

    Svehlíková V, Wang S, Jakubíková J, Williamson G, Mithen R, Bao Y Interactions between sulforaphane and apigenin in the induction of UGT1A1 and GSTA1 in CaCo-2 cells. Carcinogenesis 25 1629-1637, 2004
    DOI:10.1093/carcin/bgh169
    View abstract

    Crespy V, Nancoz N, Oliveira M, Hau J, Courtet-Compondu M-C, Williamson G Glucuronidation of the green tea catechins, (-)-epigallocatechin-3-gallate and (-)-epicatechin-3-gallate, by rat hepatic and intestinal microsomes. Free Radic Res 38 1025-1031, 2004
    DOI:10.1080/10715760410001728424
    View abstract

    Payan F, Leone P, Porciero S, Furniss C, Tahir T, Williamson G, Durand A, Manzanares P, Gilbert HJ, Juge N, Roussel A The dual nature of the wheat xylanase protein inhibitor XIP-I - Structural basis for the inhibition of family 10 and family 11 xylanases JOURNAL OF BIOLOGICAL CHEMISTRY 279 36029-36037, 2004
    DOI:10.1074/jbc.M404225200

    Janisch KM, Williamson G, Needs P, Plumb GW Properties of quercetin conjugates: Modulation of LDL oxidation and binding to human serum albumin Free Radical Research 38 877-884, 2004
    DOI:10.1080/10715760410001728415
    View abstract

    Janisch KM, Williamson G, Needs P, Plumb GW Properties of quercetin conjugates: Modulation of LDL oxidation and binding to human serum albumin FREE RADICAL RESEARCH 38 877-884, 2004
    DOI:10.1080/107157601410001728415

    O'Leary KA, de Pascual-Teresa S, Needs PW, Bao Y-P, O'Brien NM, Williamson G Effect of flavonoids and vitamin E on cyclooxygenase-2 (COX-2) transcription. Mutat Res 551 245-254, 2004
    DOI:10.1016/j.mrfmmm.2004.01.015
    View abstract

    Kroon PA, Clifford MN, Crozier A, Day AJ, Donovan JL, Manach C, Williamson G How should we assess the effects of exposure to dietary polyphenols in vitro? AM J CLIN NUTR 80 15-21, 2004

    Holst B, Williamson G A critical review of the bioavailability of glucosinolates and related compounds. Nat Prod Rep 21 425-447, 2004
    DOI:10.1039/b204039p
    View abstract

    Williamson G, Crespy V, Nancoz N Low hepatic and intestinal glucuronidation rates of galloylated green tea catechins partially explains why these flavonoids are in unconjugated forms in plasma in vivo FASEB JOURNAL 18 , 2004

    Mutch D, Anderle P, Fiaux M, Mansourian R, Vidal K, Wahli W, Williamson G, Roberts MA Regional variations in ABC transporter expression along the mouse intestinal tract FASEB JOURNAL 18 , 2004

    Roberts MA, Mutch D, Berger A, Fay L, Grigorov M, Watkins S, Williamson G, German JB A combined transcriptome and lipid-metabolome approach for unraveling the effects of an arachidonate-enriched diet FASEB JOURNAL 18 , 2004

    Garcia-Conesa MT, Crepin VF, Goldson AJ, Williamson G, Cummings NJ, Connerton IF, Faulds CB, Kroon PA The feruloyl esterase system of Talaromyces stipitatus: production of three discrete feruloyl esterases, including a novel enzyme, TsFaeC, with a broad substrate specificity JOURNAL OF BIOTECHNOLOGY 108 227-241, 2004
    DOI:10.1016/j.biotec.2003.12.003

    Garcia-Conesa M-T, Crepin VF, Goldson AJ, Williamson G, Cummings NJ, Connerton IF, Faulds CB, Kroon PA The feruloyl esterase system of Talaromyces stipitatus: production of three discrete feruloyl esterases, including a novel enzyme, TsFaeC, with a broad substrate specificity. J Biotechnol 108 227-241, 2004
    DOI:10.1016/j.jbiotec.2003.12.003
    View abstract

    Mutch DM, Anderle P, Fiaux M, Mansourian R, Vidal K, Wahli W, Williamson G, Roberts M-A Regional variations in ABC transporter expression along the mouse intestinal tract. Physiol Genomics 17 11-20, 2004
    DOI:10.1152/physiolgenomics.00150.2003
    View abstract

    de Pascual-Teresa S, Johnston KL, DuPont MS, O'Leary KA, Needs PW, Morgan LM, Clifford MN, Bao Y, Williamson G Quercetin metabolites downregulate cyclooxygenase-2 transcription in human lymphocytes ex vivo but not in vivo. J Nutr 134 552-557, 2004
    View abstract

    Adams EL, Kroon PA, Williamson G, Gilbert HJ, Morris VJ Inactivated enzymes as probes of the structure of arabinoxylans as observed by atomic force microscopy. Carbohydr Res 339 579-590, 2004
    DOI:10.1016/j.carres.2003.11.023
    View abstract

    Juge N, Payan F, Williamson G XIP-I, a xylanase inhibitor protein from wheat: a novel protein function. Biochim Biophys Acta 1696 203-211, 2004
    DOI:10.1016/j.bbapap.2003.08.014
    View abstract

    Juge N, Svensson B, Henrissat B, Williamson G Plant proteinaceous inhibitors of carbohydrate-active enzymes BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS 1696 141-141, 2004
    DOI:10.1016/j.bbapap.2003.11.002

    Soon G, Quintin A, Kastenmayer P, Antille N, Williamson G, Ginty F, Offord E LYSINE DOSE-RESPONSE ON BONE MINERAL STATUS, BONE TURNOVER AND APPARENT CALCIUM ABSORPTION IN GROWING RATS CALCIFIED TISSUE INTERNATIONAL 74 S119-S120, 2004

    Williamson G Common features in the pathways of absorption and metabolism of flavonoids PHYTOCHEMICALS: MECHANISMS OF ACTION , 2004

    Bacon JR, Williamson G, Garner RC, Lappin G, Langouët S, Bao Y Sulforaphane and quercetin modulate PhIP-DNA adduct formation in human HepG2 cells and hepatocytes. Carcinogenesis 24 1903-1911, 2003
    DOI:10.1093/carcin/bgg157
    View abstract

    Sancho AI, Faulds CB, Svensson B, Bartolomé B, Williamson G, Juge N Cross-inhibitory activity of cereal protein inhibitors against alpha-amylases and xylanases. Biochim Biophys Acta 1650 136-144, 2003
    View abstract

    Berrin J-G, Czjzek M, Kroon PA, McLauchlan WR, Puigserver A, Williamson G, Juge N Substrate (aglycone) specificity of human cytosolic beta-glucosidase. Biochem J 373 41-48, 2003
    DOI:10.1042/BJ20021876
    View abstract

    Payan F, Flatman R, Porciero S, Williamson G, Juge N, Roussel A Structural analysis of xylanase inhibitor protein I (XIP-I), a proteinaceous xylanase inhibitor from wheat (Triticum aestivum, var. Soisson) BIOCHEMICAL JOURNAL 372 399-405, 2003
    DOI:10.1042/BJ20021802

    Rowland I, Faughnan M, Hoey L, Wahala K, Williamson G, Cassidy A Bioavailability of phyto-oestrogens BRITISH JOURNAL OF NUTRITION 89 S45-S58, 2003
    DOI:10.1079/BJN2002796

    Verhagen H, Aruoma OI, van Delft JHM, Dragsted LO, Ferguson LR, Knasmuller S, Pool-Zobel BL, Poulsen HE, Williamson G, Yannai S The 10 basic requirements for a scientific paper reporting antioxidant, antimutagenic or anticarcinogenic potential of test substances in in vitro experiments and animal studies in vivo FOOD AND CHEMICAL TOXICOLOGY 41 603-610, 2003
    DOI:10.1016/S0278-6915(03)00025-5

    Adams EL, Kroon PA, Williamson G, Morris VJ Characterisation of heterogeneous arabinoxylans by direct imaging of individual molecules by atomic force microscopy. Carbohydr Res 338 771-780, 2003
    View abstract

    Day AJ, Gee JM, DuPont MS, Johnson IT, Williamson G Absorption of quercetin-3-glucoside and quercetin-4'-glucoside in the rat small intestine: the role of lactase phlorizin hydrolase and the sodium-dependent glucose transporter. Biochem Pharmacol 65 1199-1206, 2003
    View abstract

    Rios LY, Gonthier MP, Remesy C, Mila L, Lapierre C, Lazarus SA, Williamson G, Scalbert A Chocolate intake increases urinary excretion of polyphenol-derived phenolic acids in healthy human subjects AMERICAN JOURNAL OF CLINICAL NUTRITION 77 912-918, 2003

    Elliott GO, McLauchlan WR, Williamson G, Kroon PA A wheat xylanase inhibitor protein (XIP-I) accumulates in the grain and has homologues in other cereals JOURNAL OF CEREAL SCIENCE 37 187-194, 2003
    DOI:10.1006/jcrs.2002.0493

    Zhang J, Svehlíková V, Bao Y, Howie AF, Beckett GJ, Williamson G Synergy between sulforaphane and selenium in the induction of thioredoxin reductase 1 requires both transcriptional and translational modulation. Carcinogenesis 24 497-503, 2003
    View abstract

    Wilkinson AP, Gee JM, Dupont MS, Needs PW, Mellon FA, Williamson G, Johnson IT Hydrolysis by lactase phlorizin hydrolase is the first step in the uptake of daidzein glucosides by rat small intestine in vitro. Xenobiotica 33 255-264, 2003
    DOI:10.1080/0049825021000058088
    View abstract

    O'Leary KA, Day AJ, Needs PW, Mellon FA, O'Brien NM, Williamson G Metabolism of quercetin-7-and quercetin-3-glucuronides by an in vitro hepatic model: the role of human beta-glucuronidase, sulfotransferase, catechol-O-methyltransferase and multi-resistant protein 2 (MRP2) in flavonoid metabolism BIOCHEM PHARMACOL 65 479-491, 2003

    Mithen R, Faulkner K, Magrath R, Rose P, Williamson G, Marquez J Development of isothiocyanate-enriched broccoli, and its enhanced ability to induce phase 2 detoxification enzymes in mammalian cells THEORETICAL AND APPLIED GENETICS 106 727-734, 2003
    DOI:10.1007/s00122-002-1123-x

    Gunning AP, Giardina TP, Faulds CB, Juge N, Ring SG, Williamson G, Morris VJ Surfactant-mediated solubilisation of amylose and visualisation by atomic force microscopy CARBOHYDRATE POLYMERS 51 177-182, 2003
    DOI:10.1016/S0144-8617(02)00126-1

    Johnson I, Williamson G Phytochemical Functional Foods Phytochemical Functional Foods 1-384, 2003
    DOI:10.1533/9781855736986
    View abstract

    Németh K, Plumb GW, Berrin J-G, Juge N, Jacob R, Naim HY, Williamson G, Swallow DM, Kroon PA Deglycosylation by small intestinal epithelial cell beta-glucosidases is a critical step in the absorption and metabolism of dietary flavonoid glycosides in humans. Eur J Nutr 42 29-42, 2003
    DOI:10.1007/s00394-003-0397-3
    View abstract

    Williamson G The use of flavonoid aglycones in in vitro systems to test biological activities: Based on bioavailability data, is this a valid approach? Phytochemistry Reviews 1 215-222, 2002
    DOI:10.1023/A:1022515602191
    View abstract

    Tahir TA, Berrin JG, Flatman R, Roussel A, Roepstorff P, Williamson G, Juge N Specific characterization of substrate and inhibitor binding sites of a glycosyl hydrolase family 11 xylanase from Aspergillus niger JOURNAL OF BIOLOGICAL CHEMISTRY 277 44035-44043, 2002
    DOI:10.1047/jbc.M205657200

    Tahir TA, Berrin J-G, Flatman R, Roussel A, Roepstorff P, Williamson G, Juge N Specific characterization of substrate and inhibitor binding sites of a glycosyl hydrolase family 11 xylanase from Aspergillus niger. J Biol Chem 277 44035-44043, 2002
    DOI:10.1074/jbc.M205657200
    View abstract

    Wilkinson AP, Wähälä K, Williamson G Identification and quantification of polyphenol phytoestrogens in foods and human biological fluids. J Chromatogr B Analyt Technol Biomed Life Sci 777 93-109, 2002
    View abstract

    Bennett RN, Mellon FA, Botting NP, Eagles J, Rosa EAS, Williamson G Identification of the major glucosinolate (4-mercaptobutyl glucosinolate) in leaves of Eruca sativa L. (salad rocket). Phytochemistry 61 25-30, 2002
    View abstract

    Basten GP, Bao Y, Williamson G Sulforaphane and its glutathione conjugate but not sulforaphane nitrile induce UDP-glucuronosyl transferase (UGT1A1) and glutathione transferase (GSTA1) in cultured cells. Carcinogenesis 23 1399-1404, 2002
    View abstract

    Flatman R, McLauchlan WR, Juge N, Furniss C, Berrin J-G, Hughes RK, Manzanares P, Ladbury JE, O'Brien R, Williamson G Interactions defining the specificity between fungal xylanases and the xylanase-inhibiting protein XIP-I from wheat. Biochem J 365 773-781, 2002
    DOI:10.1042/BJ20020168
    View abstract

    Furniss CSM, Belshaw NJ, Alcocer MJC, Williamson G, Elliott GO, Gebruers K, Haigh NP, Fish NM, Kroon PA A family 11 xylanase from Penicillium funiculosum is strongly inhibited by three wheat xylanase inhibitors. Biochim Biophys Acta 1598 24-29, 2002
    View abstract

    Cornish KM, Williamson G, Sanderson J Quercetin metabolism in the lens: role in inhibition of hydrogen peroxide induced cataract. Free Radic Biol Med 33 63-70, 2002
    View abstract

    Mellon FA, Bennett RN, Holst B, Williamson G Intact glucosinolate analysis in plant extracts by programmed cone voltage electrospray LC/MS: performance and comparison with LC/MS/MS methods. Anal Biochem 306 83-91, 2002
    DOI:10.1006/abio.2002.5677
    View abstract

    Elliott GO, Hughes RK, Juge N, Kroon PA, Williamson G Functional identification of the cDNA coding for a wheat endo-1,4-beta-D-xylanase inhibitor. FEBS Lett 519 66-70, 2002
    View abstract

    Bao YP, Williamson G Quantification of mRNA by RT-competitive-PCR and high performance liquid chromatography PROGRESS IN NATURAL SCIENCE 12 353-358, 2002

    Aura AM, O'Leary KA, Williamson G, Ojala M, Bailey M, Puupponen-Pimia R, Nuutila AM, Oksman-Caldentey KM, Poutanen K Quercetin derivatives are deconjugated and converted to hydroxyphenylacetic acids but not methylated by human fecal flora in vitro JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 50 1725-1730, 2002
    DOI:10.1021/jf0108056

    DuPont MS, Bennett RN, Mellon FA, Williamson G Polyphenols from alcoholic apple cider are absorbed, metabolized and excreted by humans. J Nutr 132 172-175, 2002
    View abstract

    Depeint F, Gee JM, Williamson G, Johnson IT Evidence for consistent patterns between flavonoid structures and cellular activities. Proc Nutr Soc 61 97-103, 2002
    View abstract

    Stahl W, van den Berg H, Arthur J, Bast A, Dainty J, Faulks RM, Gaertner C, Haenen G, Hollman P, Holst B, Kelly FJ, Polidori MC, Rice-Evans C, Southon S, van Vliet T, Vina-Ribes J, Williamson G, Astley SB Bioavailability and metabolism MOLECULAR ASPECTS OF MEDICINE 23 39-100, 2002
    DOI:10.1016/S0098-2997(02)00016-X

    Juge N, Le Gal-Coeffet MF, Furniss CSM, Gunning AP, Kramhoft B, Morris VJ, Williamson G, Svensson B The starch binding domain of glucoamylase from Aspergillus niger: overview of its structure, function, and role in raw-starch hydrolysis BIOLOGIA 57 , 2002

    Plumb GW, de Pascual-Teresa S, Santos-Buelga C, Rivas-Gonzalo JC, Williamson G Antioxidant properties of gallocatechin and prodelphinidins from pomegranate peel. Redox Rep 7 41-46, 2002
    DOI:10.1179/135100002125000172
    View abstract

    Cano A, Arnao MB, Williamson G, Garcia-Conesa M-T Superoxide scavenging by polyphenols: effect of conjugation and dimerization. Redox Rep 7 379-383, 2002
    DOI:10.1179/135100002125001153
    View abstract

    Berrin J-G, McLauchlan WR, Needs P, Williamson G, Puigserver A, Kroon PA, Juge N Functional expression of human liver cytosolic beta-glucosidase in Pichia pastoris. Insights into its role in the metabolism of dietary glucosides. Eur J Biochem 269 249-258, 2002
    View abstract

    Svensson B, Jensen MT, Mori H, Bak-Jensen KS, Bonsager B, Nielsen PK, Kramhoft B, Praetorius-Ibba M, Nohr J, Juge N, Greffe L, Williamson G, Driguez H Fascinating facets of function and structure of amylolytic enzymes of glycoside hydrolase family 13 BIOLOGIA 57 , 2002

    Giardina T, Gunning AP, Juge N, Faulds CB, Furniss CS, Svensson B, Morris VJ, Williamson G Both binding sites of the starch-binding domain of Aspergillus niger glucoamylase are essential for inducing a conformational change in amylose. J Mol Biol 313 1149-1159, 2001
    DOI:10.1006/jmbi.2001.5097
    View abstract

    Andreasen MF, Kroon PA, Williamson G, Garcia-Conesa MT Esterase activity able to hydrolyze dietary antioxidant hydroxycinnamates is distributed along the intestine of mammals. J Agric Food Chem 49 5679-5684, 2001
    View abstract

    Hernanz D, Nunez V, Sancho AI, Faulds CB, Williamson G, Bartolome B, Gomez-Cordoves C Hydroxycinnamic acids and ferulic acid dehydrodimers in barley and processed barley JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 49 4884-4888, 2001
    DOI:10.1021/jf010530u

    Murray S, Lake BG, Gray S, Edwards AJ, Springall C, Bowey EA, Williamson G, Boobis AR, Gooderham NJ Effect of cruciferous vegetable consumption on heterocyclic aromatic amine metabolism in man CARCINOGENESIS 22 1413-1420, 2001
    DOI:10.1093/carcin/22.9.1413

    Sancho AI, Bartolome B, Gomez-Cordoves C, Williamson G, Faulds CB Release of ferulic acid from cereal residues by barley enzymatic extracts JOURNAL OF CEREAL SCIENCE 34 173-179, 2001
    DOI:10.1006/jcrs.2001.0386

    O'Leary KA, Day AJ, Needs PW, Sly WS, O'Brien NM, Williamson G Flavonoid glucuronides are substrates for human liver beta-glucuronidase FEBS LETT 503 103-106, 2001

    Andreasen MF, Kroon PA, Williamson G, Garcia-Conesa MT Intestinal release and uptake of phenolic antioxidant diferulic acids FREE RADICAL BIOLOGY AND MEDICINE 31 304-314, 2001
    DOI:10.1016/S0891-5849(01)00585-8

    Crews H, Alink G, Andersen R, Braesco V, Holst B, Maiani G, Ovesen L, Scotter M, Solfrizzo M, van den Berg R, Verhagen H, Williamson G A critical assessment of some biomarker approaches linked with dietary intake BRITISH JOURNAL OF NUTRITION 86 S5-S35, 2001
    DOI:10.1079/BJN2001337

    Juge N, Williamson G, Puigserver A, Cummings NJ, Connerton IF, Faulds CB High-level production of recombinant Aspergillus niger cinnamoyl esterase (FAEA) in the methylotrophic yeast Pichia pastoris. FEMS Yeast Res 1 127-132, 2001
    View abstract

    Couteau D, McCartney AL, Gibson GR, Williamson G, Faulds CB Isolation and characterization of human colonic bacteria able to hydrolyse chlorogenic acid. J Appl Microbiol 90 873-881, 2001
    View abstract

    Garcia-Conesa MT, Ostergaard P, Kauppinen S, Williamson G Hydrolysis of diethyl diferulates by a tannase from Aspergillus oryzae CARBOHYDRATE POLYMERS 44 , 2001
    DOI:10.1016/S0144-8617(00)00248-4

    Kuhnert N, Holst B, Williamson G Synthesis of C-14-labelled sulforaphane JOURNAL OF LABELLED COMPOUNDS&RADIOPHARMACEUTICALS 44 347-354, 2001
    DOI:10.1002/jlcr.462

    Day AJ, Williamson G, Morgan MRA Absorption and metabolism of dietary polyphenols. ABSTR PAP AM CHEM S 221 , 2001

    Cornish KM, Sanderson J, Matasconi M, Reddan J, Williamson G Quercetin inhibits hydrogen peroxide induced damage of human lens epithelial FHL124 cells. INVESTIGATIVE OPHTHALMOLOGY&VISUAL SCIENCE 42 S452-S452, 2001

    Sanderson J, Cornish K, Williamson G Uptake and metabolism of the flavonoid quercetin in the lens. INVESTIGATIVE OPHTHALMOLOGY&VISUAL SCIENCE 42 S450-S450, 2001

    Needs PW, Williamson G Syntheses of daidzein-7-yl beta-D-glucopyranosiduronic acid and daidzein-4',7-yl di-beta-D-glucopyranosiduronic acid. Carbohydr Res 330 511-515, 2001
    View abstract

    Giuliani S, Piana C, Setti L, Hochkoeppler A, Pifferi PG, Williamson G, Faulds CB Synthesis of pentylferulate by a feruloyl esterase from Aspergillus niger using water-in-oil microemulsions BIOTECHNOLOGY LETTERS 23 325-330, 2001
    DOI:10.1023/A:1005629127480

    Depeint F, Bennett RN, Gee JM, Williamson G, Johnson IT Dietary phytochemicals and cell proliferation: Screening flavonoids and isothiocyanates for structure-activity relationships (SAR) ROY SOC CH , 2001

    Day AJ, Williamson G Biomarkers for exposure to dietary flavonoids: a review of the current evidence for identification of quercetin glycosides in plasma British Journal of Nutrition 86 S105-S110, 2001

    O'Leary KA, Day AJ, Needs P, O'Brien NM, Williamson G Metabolism of quercetin glucuronides in an in vitro cell model ROY SOC CH , 2001

    Berrin JG, McLauchlan WR, Williamson G, Puigserver A, Kroon PA, Juge N Human cytosolic beta-glucosidase hydrolyses a broad range of flavonoid glycosides ROY SOC CH , 2001

    Gee JM, Day AJ, Williamson G, Johnson LT How do dietary flavonol glucosides cross the small intestinal barrier? ROY SOC CH , 2001

    Day AJ, Mellon F, Barron D, Sarrazin G, Morgan MRA, Williamson G Human metabolism of dietary flavonoids: Identification of plasma metabolites of quercetin FREE RADICAL RES 35 941-952, 2001

    Bao YP, Bacon J, Williamson G Effect of phytochemicals on PhIP-DNA adduct formation in human Hep G2 and hepatocytes ROY SOC CH , 2001

    Day AJ, Bao Y, Morgan MR, Williamson G Conjugation position of quercetin glucuronides and effect on biological activity. Free Radic Biol Med 29 1234-1243, 2000
    View abstract

    Kroon PA, Williamson G, Fish NM, Archer DB, Belshaw NJ A modular esterase from Penicillium funiculosum which releases ferulic acid from plant cell walls and binds crystalline cellulose contains a carbohydrate binding module. Eur J Biochem 267 6740-6752, 2000
    View abstract

    Rose P, Faulkner K, Williamson G, Mithen R 7-Methylsulfinylheptyl and 8-methylsulfinyloctyl isothiocyanates from watercress are potent inducers of phase II enzymes. Carcinogenesis 21 1983-1988, 2000
    View abstract

    Gee JM, DuPont MS, Day AJ, Plumb GW, Williamson G, Johnson IT Intestinal transport of quercetin glycosides in rats involves both deglycosylation and interaction with the hexose transport pathway. J Nutr 130 2765-2771, 2000
    View abstract

    Walton NJ, Narbad A, Faulds C, Williamson G Novel approaches to the biosynthesis of vanillin. Curr Opin Biotechnol 11 490-496, 2000
    View abstract

    DuPont MS, Mondin Z, Williamson G, Price KR Effect of variety, processing, and storage on the flavonoid glycoside content and composition of lettuce and endive. J Agric Food Chem 48 3957-3964, 2000
    View abstract

    Scalbert A, Williamson G Dietary intake and bioavailability of polyphenols JOURNAL OF NUTRITION 130 , 2000

    Gunning AP, Mackie AR, Kirby AR, Kroon P, Williamson G, Morris VJ Motion of a cell wall polysaccharide observed by atomic force microscopy MACROMOLECULES 33 5680-5685, 2000
    DOI:10.1021/ma000331w

    McGorum BC, Fry SC, Wallace G, Coenen K, Robb J, Williamson G, Aruoma OI Properties of herbage in relation to equine dysautonomia: Biochemical composition and antioxidant and prooxidant actions JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 48 2346-2352, 2000
    DOI:10.1021/jf991101n

    Berrin JG, Williamson G, Puigserver A, Chaix JC, McLauchlan WR, Juge N High-level production of recombinant fungal endo-beta-1,4-xylanase in the methylotrophic yeast Pichia pastoris PROTEIN EXPRESSION AND PURIFICATION 19 179-187, 2000
    DOI:10.1006/prep.2000.1229

    Faulds C, Clarke B, Williamson G Ferulic acid unearthed CHEMISTRY IN BRITAIN 36 48-50, 2000

    Bao YP, Williamson G Selenium-dependent glutathione peroxidases - A highlight of the role of phospholipid hydroperoxide glutathione peroxidase in protection against oxidative damage PROGRESS IN NATURAL SCIENCE 10 321-330, 2000

    Day AJ, Cañada FJ, Díaz JC, Kroon PA, Mclauchlan R, Faulds CB, Plumb GW, Morgan MR, Williamson G Dietary flavonoid and isoflavone glycosides are hydrolysed by the lactase site of lactase phlorizin hydrolase. FEBS Lett 468 166-170, 2000
    View abstract

    Williamson G, Day AJ, Plumb GW, Couteau D Human metabolic pathways of dietary flavonoids and cinnamates. Biochem Soc Trans 28 16-22, 2000
    View abstract

    Faulds CB, Sancho AI, Bartolome B, Williamson G Cereal esterases 2ND EUROPEAN SYMPOSIUM ON ENZYMES IN GRAIN PROCESSING, ESEGP-2 207 , 2000

    Day AJ, Morgan MRA, Rhodes MJC, Williamson G The first step in the metabolism of flavonoid glycosides DIETARY ANTICARCINOGENS AND ANTIMUTAGENS , 2000
    DOI:10.1533/9781845698188.2.55

    McLauchlan WR, Flatman RH, Sancho AI, Kakuta J, Faulds CB, Elliot GO, Kroon PA, Furniss CSM, Juge N, Ravestein P, Williamson G Xylanase inhibitors from cereals: Implications for baking, brewing and plant technology 2ND EUROPEAN SYMPOSIUM ON ENZYMES IN GRAIN PROCESSING, ESEGP-2 207 , 2000

    Bao YP, Williamson G Selenium-dependent phospholipid hydroperoxide glutathione peroxidase protects against lipid, protein and DNA damage DIETARY ANTICARCINOGENS AND ANTIMUTAGENS , 2000
    DOI:10.1533/9781845698188.5.245

    Garcia-Conesa MT, Kroon PA, Ralph J, Mellon FA, Colquhoun IJ, Saulnier L, Thibault JF, Williamson G A cinnamoyl esterase from Aspergillus niger can break plant cell wall cross-links without release of free diferulic acids. Eur J Biochem 266 644-652, 1999
    View abstract

    Lambert N, Kroon PA, Faulds CB, Plumb GW, McLauchlan WR, Day AJ, Williamson G Purification of cytosolic beta-glucosidase from pig liver and its reactivity towards flavonoid glycosides. Biochim Biophys Acta 1435 110-116, 1999
    View abstract

    Fillingham IJ, Kroon PA, Williamson G, Gilbert HJ, Hazlewood GP A modular cinnamoyl ester hydrolase from the anaerobic fungus Piromyces equi acts synergistically with xylanase and is part of a multiprotein cellulose-binding cellulase-hemicellulase complex BIOCHEMICAL JOURNAL 343 215-224, 1999
    DOI:10.1042/0264-6021:3430215

    Saulnier L, Crepeau MJ, Lahaye M, Thibault JF, Garcia-Conesa MT, Kroon PA, Williamson G Isolation and structural determination of two 5,5 '-diferuloyl oligosaccharides indicate that maize heteroxylans are covalently cross-linked by oxidatively coupled ferulates CARBOHYDRATE RESEARCH 320 82-92, 1999
    DOI:10.1016/S0008-6215(99)00152-4

    Hurst R, St John J, Barratt CLR, Bao YP, Williamson G Role of phospholipid hydroperoxide glutathione peroxidase activity in protection against phospholipid damage in human sperm. FASEB JOURNAL 13 A1365-A1365, 1999

    Southall SM, Simpson PJ, Gilbert HJ, Williamson G, Williamson MP The starch-binding domain from glucoamylase disrupts the structure of starch. FEBS Lett 447 58-60, 1999
    View abstract

    Hurst R, Bao Y, Ridley S, Williamson G Phospholipid hydroperoxide cysteine peroxidase activity of human serum albumin. Biochem J 338 ( Pt 3) 723-728, 1999
    View abstract

    McLauchlan WR, Garcia-Conesa MT, Williamson G, Roza M, Ravestein P, Maat J A novel class of protein from wheat which inhibits xylanases. Biochem J 338 ( Pt 2) 441-446, 1999
    View abstract

    Aliwan FO, Kroon PA, Faulds CB, Pickersgill R, Williamson G Ferulic acid esterase-III from Aspergillus niger does not exhibit lipase activity JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE 79 , 1999
    DOI:10.1002/(SICI)1097-0010(19990301)79:3<457::AID-JSFA283>3.3.CO;2-7

    Garcia-Conesa MT, Wilson PD, Plumb GW, Ralph J, Williamson G Antioxidant properties of 4,4 '-dihydroxy-3,3 '-dimethoxy-beta,beta '-bicinnamic acid (8-8-diferulic acid, non-cyclic form) JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE 79 , 1999
    DOI:10.1002/(SICI)1097-0010(19990301)79:3<379::AID-JSFA259>3.0.CO;2-V

    Faulds CB, Williamson G Effect of hydroxycinnamates and benzoates on the production of feruloyl esterases by Aspergillus niger JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE 79 , 1999
    DOI:10.1002/(SICI)1097-0010(19990301)79:3<450::AID-JSFA277>3.3.CO;2-3

    Kroon PA, Garcia-Conesa MT, Fillingham IJ, Hazlewood GP, Williamson G Release of ferulic acid dehydrodimers from plant cell walls by feruloyl esterases JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE 79 , 1999

    Sanderson J, McLauchlan WR, Williamson G Quercetin inhibits hydrogen peroxide-induced oxidation of the rat lens. Free Radic Biol Med 26 639-645, 1999
    View abstract

    Plumb GW, Garcia-Conesa MT, Kroon PA, Rhodes M, Ridley S, Williamson G Metabolism of chlorogenic acid by human plasma, liver, intestine and gut microflora JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE 79 , 1999
    DOI:10.1002/(SICI)1097-0010(19990301)79:3<390::AID-JSFA258>3.3.CO;2-S

    Sancho AI, Faulds CB, Bartolome B, Williamson G Characterisation of feruloyl esterase activity in barley JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE 79 , 1999
    DOI:10.1002/(SICI)1097-0010(19990301)79:3<447::AID-JSFA276>3.3.CO;2-2

    Kroon PA, Williamson G Hydroxycinnamates in plants and food: current and future perspectives JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE 79 , 1999
    DOI:10.1002/(SICI)1097-0010(19990301)79:3<355::AID-JSFA255>3.0.CO;2-G

    Faulds CB, Williamson G The role of hydroxycinnamates in the plant cell wall JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE 79 , 1999
    DOI:10.1002/(SICI)1097-0010(19990301)79:3<393::AID-JSFA261>3.0.CO;2-H

    Luonteri E, Kroon PA, Tenkanen M, Teleman A, Williamson G Activity of an Aspergillus terreus alpha-arabinofuranosidase on phenolic-substituted oligosaccharides. J Biotechnol 67 41-48, 1999
    View abstract

    Williamson G, Plumb GW, Garcia-Conesa MT Glycosylation, esterification and polymerization of flavonoids and hydroxycinnamates: effects on antioxidant properties. Basic Life Sci 66 483-494, 1999

    Plumb GW, Price KR, Williamson G Antioxidant properties of flavonol glycosides from tea. Redox Rep 4 13-16, 1999
    DOI:10.1179/135100099101534684
    View abstract

    Plumb GW, Price KR, Williamson G Antioxidant properties of flavonol glycosides from green beans. Redox Rep 4 123-127, 1999
    DOI:10.1179/135100099101534800
    View abstract

    Day AJ, Williamson G Human metabolism of dietary quercetin glycosides. Basic Life Sci 66 415-434, 1999

    Plumb GW, De Pascual-Teresa S, Santos-Buelga C, Cheynier V, Williamson G Antioxidant properties of catechins and proanthocyanidins: effect of polymerisation, galloylation and glycosylation. Free Radic Res 29 351-358, 1998
    View abstract

    Bao YP, Williamson G, Tew D, Plumb GW, Lambert N, Jones JG, Menon DK Antioxidant effects of propofol in human hepatic microsomes: concentration effects and clinical relevance BRITISH JOURNAL OF ANAESTHESIA 81 584-589, 1998

    Day AJ, DuPont MS, Ridley S, Rhodes M, Rhodes MJ, Morgan MR, Williamson G Deglycosylation of flavonoid and isoflavonoid glycosides by human small intestine and liver beta-glucosidase activity. FEBS Lett 436 71-75, 1998
    View abstract

    Wang H, Williamson G, Peng RX An expressional system of human cytochrome P-450 CYP1A1 gene transcription. Zhongguo Yao Li Xue Bao 19 429-432, 1998
    View abstract

    Williamson G, Kroon PA, Faulds CB Hairy plant polysaccharides: a close shave with microbial esterases. Microbiology 144 ( Pt 8) 2011-2023, 1998
    DOI:10.1099/00221287-144-8-2011

    Yannai S, Day AJ, Williamson G, Rhodes MJ Characterization of flavonoids as monofunctional or bifunctional inducers of quinone reductase in murine hepatoma cell lines. Food Chem Toxicol 36 623-630, 1998
    View abstract

    Ralph J, Conesa MTG, Williamson G Simple preparation of 8-5-coupled diferulate JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 46 2531-2532, 1998
    DOI:10.1021/jf980123r

    Knasmuller S, Parzefall W, Sanyal R, Ecker S, Schwab C, Uhl M, Mersch-Sundermann V, Williamson G, Hietsch G, Langer T, Darroudi F, Natarajan AT Use of metabolically competent human hepatoma cells for the detection of mutagens and antimutagens MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS 402 , 1998
    DOI:10.1016/S0027-5107(97)00297-2

    Hurst R, Bao Y, Jemth P, Mannervik B, Williamson G Phospholipid hydroperoxide glutathione peroxidase activity of human glutathione transferases. Biochem J 332 ( Pt 1) 97-100, 1998
    View abstract

    Garcia-Conesa MT, Kroon PA, Williamson G Enzymic hydrolysis of diferulates from wheat bran cell walls. Biochem Soc Trans 26 S168-, 1998

    Kroon PA, Williamson G Three distinct ferulic acid esterases produced by Aspergillus niger have specificities for different phenolic-sugar linkages in plant cell walls. Biochem Soc Trans 26 S167-, 1998

    Plumb GW, Garcia-Conesa MT, Kroon PA, Wallace G, Williamson G Properties of ferulate dimers from plant cell walls. Biochem Soc Trans 26 S166-, 1998

    Aliwan FO, Williamson G Identification of active site residues in a ferulic acid esterase (FAE-III) from Aspergillus niger. Biochem Soc Trans 26 S164-, 1998

    Williamson G, Faulds CB, Kroon PA Specificity of ferulic acid (feruloyl) esterases. Biochem Soc Trans 26 205-209, 1998

    Gottschalk TE, Fierobe HP, Mirgorodskaya E, Clarke AJ, Tull D, Sigurskjold BW, Christensen T, Payre N, Frandsen TP, Juge N, McGuire KA, Cottaz S, Roepstorff P, Driguez H, Williamson G, Svensson B Structure, function and protein engineering of starch-degrading enzymes BIOCHEMICAL SOCIETY TRANSACTIONS 26 , 1998

    Juge N, Svensson B, Williamson G Secretion, purification, and characterisation of barley alpha-amylase produced by heterologous gene expression in Aspergillus niger. Appl Microbiol Biotechnol 49 385-392, 1998
    View abstract

    Faulkner K, Mithen R, Williamson G Selective increase of the potential anticarcinogen 4-methylsulphinylbutyl glucosinolate in broccoli. Carcinogenesis 19 605-609, 1998
    View abstract

    McLauchlan WR, Sanderson J, Quinlan M, Williamson G Measurement of the total antioxidant activity of human aqueous humor CLINICAL CHEMISTRY 44 888-889, 1998

    Williamson G, Faulkner K, Plumb GW Glucosinolates and phenolics as antioxidants from plant foods. Eur J Cancer Prev 7 17-21, 1998
    View abstract

    Bao YP, Hurst R, Williamson G High performance liquid chromatographic separation of hydroperoxy-phospholipids and their corresponding hydroxy-phospholipid derivatives JOURNAL OF LIQUID CHROMATOGRAPHY&RELATED TECHNOLOGIES 21 2061-2068, 1998
    DOI:10.1080/10826079808006605

    Thibault JF, Asther M, Ceccaldi BC, Couteau D, Delattre M, Duarte JC, Faulds C, Heldt-Hansen HP, Kroon P, Lesage-Meessen L, Micard V, Renard CMGC, Tuohy M, Van Hulle S, Williamson G Fungal bioconversion of agricultural by-products to vanillin FOOD SCIENCE AND TECHNOLOGY-LEBENSMITTEL-WISSENSCHAFT&TECHNOLOGIE 31 530-536, 1998

    Faulds CB, Aliwan FO, de Vries RP, Pickersgill RW, Visser J, Williamson G Chemical and thermal stability of ferulic acid (feruloyl) esterases from Aspergillus. STABILITY AND STABILIZATION OF BIOCATALYSTS 15 , 1998

    Faulds CB, deVries RP, Kroon PA, Visser J, Williamson G Influence of ferulic acid on the production of feruloyl esterases by Aspergillus niger. FEMS Microbiol Lett 157 239-244, 1997
    View abstract

    Uda Y, Price KR, Williamson G, Rhodes MJC Induction of the anticarcinogenic marker enzyme, quinone reductase, in murine hepatoma cells in vitro by flavonoids Cancer Letters 120 213-216, 1997
    DOI:10.1016/S0304-3835(97)00311-X
    View abstract

    deVries RP, Michelsen B, Poulsen CH, Kroon PA, vandenHeuvel RHH, Faulds CB, Williamson G, vandenHombergh JPTW, Visser J The faeA genes from Aspergillus niger and Aspergillus tubingensis encode ferulic acid esterases involved in degradation of complex cell wall polysaccharides APPLIED AND ENVIRONMENTAL MICROBIOLOGY 63 4638-4644, 1997

    McLauchlan WR, Sanderson J, Williamson G Quercetin protects against hydrogen peroxide--induced cataract. Biochem Soc Trans 25 S581-, 1997

    Plumb GW, Dupont MS, Williamson G Modulation of AAPH-induced oxidative stress in cell culture by flavonoids. Biochem Soc Trans 25 S560-, 1997

    Hurst R, Bao Y, Jemth P, Mannervik B, Williamson G Phospholipid hydroperoxide glutathione peroxidase activity of rat class theta glutathione transferase T2-2. Biochem Soc Trans 25 S559-, 1997

    Makkinje M, Bao Y, Ridley S, Williamson G Regulation of phospholipase A2 gene expression by tumour necrosis factor alpha in human HepG2 cells. Biochem Soc Trans 25 S558-, 1997

    Bao Y, Williamson G Phospholipid hydroperoxide peroxidase activities in erythrocytes. Biochem Soc Trans 25 S557-, 1997

    Bao Y, Williamson G alpha-Tocopherol enhances the peroxidase activity of hemoglobin on phospholipid hydroperoxide. Redox Rep 3 325-330, 1997
    View abstract

    Garcia-Conesa MT, Plumb GW, Waldron KW, Ralph J, Williamson G Ferulic acid dehydrodimers from wheat bran: isolation, purification and antioxidant properties of 8-O-4-diferulic acid. Redox Rep 3 319-323, 1997
    View abstract

    Plumb GW, Price KR, Rhodes MJ, Williamson G Antioxidant properties of the major polyphenolic compounds in broccoli. Free Radic Res 27 429-435, 1997
    View abstract

    Plumb GW, Chambers SJ, Lambert N, Wanigatunga S, Williamson G Influence of fruit and vegetable extracts on lipid peroxidation in microsomes containing specific cytochrome P450s FOOD CHEMISTRY 60 161-164, 1997
    DOI:10.1016/S0308-8146(95)00256-1

    Williamson G, DuPont MS, Wanigatunga S, Heaney RK, Musk SRR, Fenwick GR, Rhodes MJC Induction of glutathione S-transferase activity in hepG2 cells by extracts from fruits and vegetables FOOD CHEMISTRY 60 157-160, 1997
    DOI:10.1016/S0308-8146(95)00255-3

    Manson MM, Ball HWL, Barrett MC, Clark HL, Judah DJ, Williamson G, Neal GE Mechanism of action of dietary chemoprotective agents in rat liver: induction of phase I and II drug metabolizing enzymes and aflatoxin B-1 metabolism CARCINOGENESIS 18 1729-1738, 1997
    DOI:10.1093/carcin/18.9.1729

    Kroon PA, Faulds CB, Brézillon C, Williamson G Methyl phenylalkanoates as substrates to probe the active sites of esterases. Eur J Biochem 248 245-251, 1997
    View abstract

    Williamson G, Vallejo J Chemical and thermal stability of ferulic acid esterase-III from Aspergillus niger. Int J Biol Macromol 21 163-167, 1997
    View abstract

    GarciaConesa MT, Plumb GW, Kroon PA, Wallace G, Williamson G Antioxidant properties of ferulic acid dimers REDOX REPORT 3 239-244, 1997

    Faulds CB, Bartolome B, Williamson G Novel biotransformations of agro-industrial cereal waste by ferulic acid esterases INDUSTRIAL CROPS AND PRODUCTS 6 , 1997
    DOI:10.1016/S0926-6690(97)00027-7

    Bao Y, Jemth P, Mannervik B, Williamson G Reduction of thymine hydroperoxide by phospholipid hydroperoxide glutathione peroxidase and glutathione transferases. FEBS Lett 410 210-212, 1997
    View abstract

    Williamson MP, Le Gal-Coëffet MF, Sorimachi K, Furniss CS, Archer DB, Williamson G Function of conserved tryptophans in the Aspergillus niger glucoamylase 1 starch binding domain. Biochemistry 36 7535-7539, 1997
    DOI:10.1021/bi9702896
    View abstract

    Kroon PA, Conesa MTG, Colquhoun IJ, Williamson G Process for the isolation of preparative quantities of [2-O-(trans-feruloyl)-alpha-L-arabinofuranosyl]-(1->5)-L-arabinofuranose from sugarbeet CARBOHYDRATE RESEARCH 300 351-354, 1997
    DOI:10.1016/S0008-6215(97)00057-8

    Sorimachi K, Le Gal-Coëffet MF, Williamson G, Archer DB, Williamson MP Solution structure of the granular starch binding domain of Aspergillus niger glucoamylase bound to beta-cyclodextrin. Structure 5 647-661, 1997
    View abstract

    Bartolome B, Faulds CB, Williamson G Enzymic release of ferulic acid from barley spent grain JOURNAL OF CEREAL SCIENCE 25 285-288, 1997
    DOI:10.1006/jcrs.1996.0091

    Wang H, Griffiths S, Williamson G Effect of glucosinolate breakdown products on beta-naphthoflavone-induced expression of human cytochrome P450 1A1 via the Ah receptor in Hep G2 cells CANCER LETTERS 114 , 1997
    DOI:10.1016/S0304-3835(97)04640-5

    Sanderson J, McLauchlan R, Williamson G, Plumb G The effect of flavonoids on hydrogen peroxide induced opacification of the isolated rat lens INVESTIGATIVE OPHTHALMOLOGY&VISUAL SCIENCE 38 5377-5377, 1997

    Laurie JI, Clarke JH, Ciruela A, Faulds CB, Williamson G, Gilbert HJ, Rixon JE, MillwardSadler J, Hazlewood GP The NodB domain of a multidomain xylanase from Cellulomonas fimi deacetylates acetylxylan FEMS MICROBIOLOGY LETTERS 148 261-264, 1997
    DOI:10.1016/S0378-1097(97)00046-3

    Kroon PA, Faulds CB, Ryden P, Robertson JA, Williamson G Release of covalently bound ferulic acid from fiber in the human colon JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 45 661-667, 1997
    DOI:10.1021/jf9604403

    Russell Mclauchlan W, Sanderson J, Williamson G 33 Quercetin protects against hydrogen peroxide - Induced cataract Biochemical Society Transactions 25 -, 1997

    Bao Y, Williamson G 1 Phospholipid hydroperoxide peroxidase activities in erythrocytes Biochemical Society Transactions 25 -, 1997

    Williamson G, Wang B, Symms C Human Hep G2 cells as a model to examine induction of quinone reductase In Vitro Toxicology: Journal of Molecular and Cellular Toxicology 10 81-84, 1997
    View abstract

    Bartolomé B, Faulds CB, Kroon PA, Waldron K, Gilbert HJ, Hazlewood G, Williamson G An Aspergillus niger esterase (ferulic acid esterase III) and a recombinant Pseudomonas fluorescens subsp. cellulosa esterase (Xy1D) release a 5-5' ferulic dehydrodimer (diferulic acid) from barley and wheat cell walls. Appl Environ Microbiol 63 208-212, 1997
    View abstract

    Moore J, Bamforth CW, Kroon PA, Bartolome B, Williamson G Ferulic acid esterase catalyses the solubilization of beta-glucans and pentosans from the starchy endosperm cell walls of barley BIOTECHNOLOGY LETTERS 18 1423-1426, 1996
    DOI:10.1007/BF00129347

    Bao Y, Williamson G Metabolism of hydroperoxy-phospholipids in human hepatoma HepG2 cells. J Lipid Res 37 2351-2360, 1996
    View abstract

    Williamson G, Plumb GW, Uda Y, Price KR, Rhodes MJ Dietary quercetin glycosides: antioxidant activity and induction of the anticarcinogenic phase II marker enzyme quinone reductase in Hepalclc7 cells. Carcinogenesis 17 2385-2387, 1996
    View abstract

    Plumb GW, Chambers SJ, Lambert N, Bartolome B, Heaney RK, Wanigatunga S, Aruoma OI, Halliwell B, Williamson G Antioxidant actions of fruit, herb and spice extracts JOURNAL OF FOOD LIPIDS 3 171-188, 1996
    DOI:10.1111/j.1745-4522.1996.tb00065.x

    Chambers SJ, Lambert N, Plumb GW, Williamson G Evaluation of the antioxidant properties of a methanolic extract from 'Juice Plus fruit' and 'Juice Plus vegetable' (dietary supplements) FOOD CHEMISTRY 57 271-274, 1996
    DOI:10.1016/0308-8146(95)00223-5

    Bao Y, Williamson G The peroxidase activity of glutathione S-transferase A1-1 on hydroperoxy-phospholipids. Biochem Soc Trans 24 462S-, 1996

    Faulds CB, Williamson G A major bioactive component of plant cell walls, ferulic acid, influences feruloyl esterase production in Aspergillus niger. Biochem Soc Trans 24 386S-, 1996

    Sanderson J, McLauchlan WR, Williamson G Can carotenoids reduce oxidation-induced cataract? Biochem Soc Trans 24 385S-, 1996

    Kroon PA, Faulds CB, Ryden P, Williamson G Solubilisation of ferulic acid from plant cell wall materials in a model human gut system. Biochem Soc Trans 24 384S-, 1996

    Williamson G, Wang H, Griffiths S Glucosinolates as bioactive components of Brassica vegetables: induction of cytochrome P450 1A1 in Hep G2 cells as assessed using transient transfection. Biochem Soc Trans 24 383S-, 1996

    Furniss CS, Williamson G Raw starch digestion. Biochem Soc Trans 24 382S-, 1996

    Plumb GW, Lambert N, Chambers SJ, Clarke HL, Manson MM, Neal G, Williamson G Effect of ethoxyquin on glutathione levels and peroxidisability of rat liver membranes. Biochem Soc Trans 24 380S-, 1996

    Bartolome B, Garcia-Conesa MT, Williamson G Release of the bioactive compound, ferulic acid, from malt extracts. Biochem Soc Trans 24 379S-, 1996

    Wang B, Lambert N, Williamson G Influence of phenolics on protein binding to the antioxidant responsive element (ARE) BIOCHEMICAL SOCIETY TRANSACTIONS 24 , 1996

    Plumb GW, Lambert N, Chambers SJ, Wanigatunga S, Heaney RK, Plumb JA, Aruoma OI, Halliwell B, Miller NJ, Williamson G Are whole extracts and purified glucosinolates from cruciferous vegetables antioxidants? Free Radic Res 25 75-86, 1996
    View abstract

    Sorimachi K, Jacks AJ, Le Gal-Coëffet MF, Williamson G, Archer DB, Williamson MP Solution structure of the granular starch binding domain of glucoamylase from Aspergillus niger by nuclear magnetic resonance spectroscopy. J Mol Biol 259 970-987, 1996
    DOI:10.1006/jmbi.1996.0374
    View abstract

    Wang B, Williamson G Transcriptional regulation of the human NAD(P)H:quinone oxidoreductase (NQO1) gene by monofunctional inducers. Biochim Biophys Acta 1307 104-110, 1996
    View abstract

    Kroon PA, Williamson G Release of ferulic acid from sugar-beet pulp by using arabinanase, arabinofuranosidase and an esterase from Aspergillus niger. Biotechnol Appl Biochem 23 ( Pt 3) 263-267, 1996
    View abstract

    Kroon PA, Faulds CB, Williamson G Purification and characterization of a novel esterase induced by growth of Aspergillus niger on sugar-beet pulp. Biotechnol Appl Biochem 23 ( Pt 3) 255-262, 1996
    View abstract

    Brezillon C, Kroon PA, Faulds CB, Brett GM, Williamson G Novel ferulic acid esterases are induced by growth of Aspergillus niger on sugarbeet pulp APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 45 371-376, 1996

    Lambert N, Chambers SJ, Plumb GW, Williamson G Human cytochrome P450's are pro-oxidants in iron/ascorbate-initiated microsomal lipid peroxidation. Free Radic Res 24 177-185, 1996
    View abstract

    Kroon PA, Faulds CB, Brezillon C, Williamson G Enzymic release of ferulic acid from sugar beet pulp using a specific esterase from Aspergillus niger PECTINS AND PECTINASES 14 , 1996
    DOI:10.1016/S0921-0423(96)80313-3

    APPARU C, DRIGUEZ H, WILLIAMSON G, SVENSSON B CHEMOENZYMATIC SYNTHESIS OF 6-OMEGA-S-ALPHA-D-GLUCOPYRANOSYL-6-OMEGA-THIOMALTOOLIGOSACCHARIDES - THEIR BINDING TO ASPERGILLUS-NIGER GLUCOAMYLASE G1 AND ITS STARCH-BINDING DOMAIN CARBOHYDRATE RESEARCH 277 313-320, 1995
    DOI:10.1016/0008-6215(95)00221-E

    FAULDS CB, WILLIAMSON G RELEASE OF FERULIC ACID FROM WHEAT BRAN BY A FERULIC ACID ESTERASE (FAE-III) FROM ASPERGILLUS-NIGER APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 43 1082-1087, 1995

    JACKS AJ, SORIMACHI K, LEGALCOEFFET MF, WILLIAMSON G, ARCHER DB, WILLIAMSON MP H-1 AND N-15 ASSIGNMENTS AND SECONDARY STRUCTURE OF THE STARCH-BINDING DOMAIN OF GLUCOAMYLASE FROM ASPERGILLUS-NIGER EUROPEAN JOURNAL OF BIOCHEMISTRY 233 568-578, 1995
    DOI:10.1111/j.1432-1033.1995.568_2.x

    Jacks AJ, Sorimachi K, Le Gal-Coëffet MF, Williamson G, Archer DB, Williamson MP 1H and 15N assignments and secondary structure of the starch-binding domain of glucoamylase from Aspergillus niger. Eur J Biochem 233 568-578, 1995
    View abstract

    Le Gal-Coëffet MF, Jacks AJ, Sorimachi K, Williamson MP, Williamson G, Archer DB Expression in Aspergillus niger of the starch-binding domain of glucoamylase. Comparison with the proteolytically produced starch-binding domain. Eur J Biochem 233 561-567, 1995
    View abstract

    BARTOLOME B, FAULDS CB, TUOHY M, HAZLEWOOD GP, GILBERT HJ, WILLIAMSON G INFLUENCE OF DIFFERENT XYLANASES ON THE ACTIVITY OF FERULIC ACID ESTERASE ON WHEAT BRAN BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY 22 65-73, 1995

    Tawfiq N, Heaney RK, Plumb JA, Fenwick GR, Musk SR, Williamson G Dietary glucosinolates as blocking agents against carcinogenesis: glucosinolate breakdown products assessed by induction of quinone reductase activity in murine hepa1c1c7 cells. Carcinogenesis 16 1191-1194, 1995
    View abstract

    McLauchlan WR, Sanderson J, Williamson G Antioxidants and the prevention of cataract. Biochem Soc Trans 23 257S-, 1995

    Plumb GW, Chambers SJ, Lambert N, Wanigatunga S, Fenwick GR, Williamson G Evaluation of the antioxidant properties of food extracts. Biochem Soc Trans 23 254S-, 1995

    Faulds CB, Williamson G Release of the antioxidant, ferulic acid, from plant material by specific esterases. Biochem Soc Trans 23 253S-, 1995

    Faulds CB, Ralet MC, Williamson G, Hazlewood GP, Gilbert HJ Specificity of an esterase (XYLD) from Pseudomonas fluorescens subsp. cellulosa. Biochim Biophys Acta 1243 265-269, 1995
    View abstract

    Bao Y, Chambers SJ, Williamson G Direct separation of hydroperoxy- and hydroxy-phosphatidylcholine derivatives: application to the assay of phospholipid hydroperoxide glutathione peroxidase. Anal Biochem 224 395-399, 1995
    View abstract

    FAULDS CB, KROON PA, SAULNIER L, THIBAULT JF, WILLIAMSON G RELEASE OF FERULIC ACID FROM MAIZE BRAN AND DERIVED OLIGOSACCHARIDES BY ASPERGILLUS-NIGER ESTERASES CARBOHYDRATE POLYMERS 27 187-190, 1995
    DOI:10.1016/0144-8617(95)00073-G

    Jacks AJ, Sorimachi K, Le Gal Coëffet M, Williamson G, Archer DB, Williamson MP 1H and15N Assignments and Secondary Structure of the Starch‐Binding Domain of Glucoamylase from Aspergillus niger European Journal of Biochemistry 233 568-578, 1995
    DOI:10.1111/j.1432-1033.1995.568_2.x
    View abstract

    Wang B, Williamson G Detection of a nuclear protein which binds specifically to the antioxidant responsive element (ARE) of the human NAD(P) H:quinone oxidoreductase gene. Biochim Biophys Acta 1219 645-652, 1994
    View abstract

    Colquhoun IJ, Ralet MC, Thibault JF, Faulds CB, Williamson G Structure identification of feruloylated oligosaccharides from sugar-beet pulp by NMR spectroscopy. Carbohydr Res 263 243-256, 1994
    View abstract

    RALET MC, THIBAULT JF, FAULDS CB, WILLIAMSON G ISOLATION AND PURIFICATION OF FERULOYLATED OLIGOSACCHARIDES FROM CELL-WALLS OF SUGAR-BEET PULP CARBOHYDRATE RESEARCH 263 227-241, 1994
    DOI:10.1016/0008-6215(94)00175-8

    RALET MC, FAULDS CB, WILLIAMSON G, THIBAULT JF DEGRADATION OF FERULOYLATED OLIGOSACCHARIDES FROM SUGAR-BEET PULP AND WHEAT BRAN BY FERULIC ACID ESTERASES FROM ASPERGILLUS-NIGER CARBOHYDRATE RESEARCH 263 257-269, 1994
    DOI:10.1016/0008-6215(94)00177-4

    SIGURSKJOLD BW, SVENSSON B, WILLIAMSON G, DRIGUEZ H THERMODYNAMICS OF LIGAND-BINDING TO THE STARCH-BINDING DOMAIN OF GLUCOAMYLASE FROM ASPERGILLUS-NIGER EUROPEAN JOURNAL OF BIOCHEMISTRY 225 133-141, 1994
    DOI:10.1111/j.1432-1033.1994.00133.x

    Chambers SJ, Lambert N, Williamson G Purification of a cytosolic enzyme from human liver with phospholipid hydroperoxide glutathione peroxidase activity. Int J Biochem 26 1279-1286, 1994
    View abstract

    GUNNING AP, MORRIS VJ, WILLIAMSON G, BELSHAW NJ, KRAMER GFH, KANNING MW IMAGING GLUCOAMYLASE BY SCANNING-TUNNELING-MICROSCOPY ANALYST 119 1939-1942, 1994
    DOI:10.1039/an9941901939

    Tawfiq N, Wanigatunga S, Heaney RK, Musk SR, Williamson G, Fenwick GR Induction of the anti-carcinogenic enzyme quinone reductase by food extracts using murine hepatoma cells. Eur J Cancer Prev 3 285-292, 1994
    View abstract

    FAULDS CB, WILLIAMSON G PURIFICATION AND CHARACTERIZATION OF A FERULIC ACID ESTERASE (FAE-III) FROM ASPERGILLUS-NIGER - SPECIFICITY FOR THE PHENOLIC MOIETY AND BINDING TO MICROCRYSTALLINE CELLULOSE MICROBIOLOGY-SGM 140 779-787, 1994

    Johnson IT, Williamson G, Musk SR Anticarcinogenic factors in plant foods: a new class of nutrients? Nutr Res Rev 7 175-204, 1994
    DOI:10.1079/NRR19940011

    FERREIRA LMA, WOOD TM, WILLIAMSON G, FAULDS C, HAZLEWOOD GP, BLACK GW, GILBERT HJ A MODULAR ESTERASE FROM PSEUDOMONAS-FLUORESCENS SUBSP CELLULOSA CONTAINS A NONCATALYTIC CELLULOSE-BINDING DOMAIN BIOCHEMICAL JOURNAL 294 349-355, 1993

    KRAMER GFH, GUNNING AP, MORRIS VJ, BELSHAW NJ, WILLIAMSON G SCANNING-TUNNELING-MICROSCOPY OF ASPERGILLUS-NIGER GLUCOAMYLASES JOURNAL OF THE CHEMICAL SOCIETY-FARADAY TRANSACTIONS 89 2595-2602, 1993
    DOI:10.1039/ft9938902595

    Faulds CB, Williamson G Ferulic acid esterase from Aspergillus niger: purification and partial characterization of two forms from a commercial source of pectinase. Biotechnol Appl Biochem 17 ( Pt 3) 349-359, 1993
    View abstract

    Belshaw NJ, Williamson G Specificity of the binding domain of glucoamylase 1. Eur J Biochem 211 717-724, 1993
    View abstract

    WILLIAMSON G, BELSHAW NJ PROPERTIES OF THE BINDING DOMAIN OF GLUCOAMYLASE CARBOHYDRATE POLYMERS 21 147-149, 1993
    DOI:10.1016/0144-8617(93)90009-S

    FAULDS CB, WILLIAMSON G RELEASE OF FERULIC ACID FROM PLANT POLYSACCHARIDES BY FERULIC ACID ESTERASE FROM STREPTOMYCES-OLIVOCHROMOGENES CARBOHYDRATE POLYMERS 21 153-155, 1993
    DOI:10.1016/0144-8617(93)90011-R

    WILLIAMSON G IN-VITRO METHODOLOGY FOOD AND CANCER PREVENTION: CHEMICAL AND BIOLOGICAL ASPECTS , 1993
    DOI:10.1533/9781845698256.8.435

    Faulds C, Williamson G Ferulic acid esterase from Aspergillus niger: purification and partial characterization of two forms from a commercial source of pectinase Biotechnology and Applied Biochemistry 17 349-359, 1993
    DOI:10.1111/j.1470-8744.1993.tb00249.x
    View abstract

    Williamson G, Damani K, Devenney P, Faulds CB, Morris VJ, Stevens BJ Mechanism of action of cyclic beta-1,2-glucan synthetase from Agrobacterium tumefaciens: competition between cyclization and elongation reactions. J Bacteriol 174 7941-7947, 1992
    View abstract

    Williamson G, Belshaw NJ, Noel TR, Ring SG, Williamson MP O-glycosylation and stability. Unfolding of glucoamylase induced by heat and guanidine hydrochloride. Eur J Biochem 207 661-670, 1992
    View abstract

    Williamson G, Belshaw NJ, Williamson MP O-glycosylation in Aspergillus glucoamylase. Conformation and role in binding. Biochem J 282 ( Pt 2) 423-428, 1992
    View abstract

    WILLIAMSON G, BELSHAW NJ, SELF DJ, NOEL TR, RING SG, CAIRNS P, MORRIS VJ, CLARK SA, PARKER ML HYDROLYSIS OF A-TYPE AND B-TYPE CRYSTALLINE POLYMORPHS OF STARCH BY ALPHA-AMYLASE, BETA-AMYLASE AND GLUCOAMYLASE-1 CARBOHYDRATE POLYMERS 18 179-187, 1992
    DOI:10.1016/0144-8617(92)90062-U

    Faulds CB, Williamson G The purification and characterization of 4-hydroxy-3-methoxycinnamic (ferulic) acid esterase from Streptomyces olivochromogenes. J Gen Microbiol 137 2339-2345, 1991
    DOI:10.1099/00221287-137-10-2339
    View abstract

    Belshaw NJ, Williamson G Interaction of beta-cyclodextrin with the granular starch binding domain of glucoamylase. Biochim Biophys Acta 1078 117-120, 1991
    View abstract

    WILLIAMSON G PURIFICATION AND CHARACTERIZATION OF PECTIN ACETYLESTERASE FROM ORANGE PEEL PHYTOCHEMISTRY 30 445-449, 1991
    DOI:10.1016/0031-9422(91)83701-L

    Belshaw NJ, Williamson G Production and purification of a granular-starch-binding domain of glucoamylase 1 from Aspergillus niger. FEBS Lett 269 350-353, 1990
    View abstract

    WILLIAMSON G, FAULDS CB, MATTHEW JA, ARCHER DB, MORRIS VJ, BROWNSEY GJ, RIDOUT MJ GELATION OF SUGAR-BEET AND CITRUS PECTINS USING ENZYMES EXTRACTED FROM ORANGE PEEL CARBOHYDRATE POLYMERS 13 387-397, 1990
    DOI:10.1016/0144-8617(90)90038-T

    Williamson G Multiple forms of glutathione S-transferase from pig liver--reaction with methyl linoleate hydroperoxides. Int J Biochem 21 23-30, 1989
    View abstract

    WILLIAMSON G PURIFICATION OF GLUTATHIONE S-TRANSFERASE FROM LAMB MUSCLE AND ITS EFFECT ON LIPID-PEROXIDATION JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE 48 347-360, 1989
    DOI:10.1002/jsfa.2740480310

    WILLIAMSON G, BEVERLEY MC WHEAT GLUTATHIONE S-TRANSFERASE - PURIFICATION AND PROPERTIES JOURNAL OF CEREAL SCIENCE 8 155-163, 1988

    Williamson G, Edmondson DE, Müller F Oxidation-reduction potential studies on p-hydroxybenzoate hydroxylase from Pseudomonas fluorescens. Biochim Biophys Acta 953 258-262, 1988
    View abstract

    WILLIAMSON G, BALL SKM PURIFICATION OF GLUTATHIONE S-TRANSFERASE FROM LEAN PORK MUSCLE AND ITS REACTIVITY WITH SOME LIPID OXIDATION-PRODUCTS JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE 44 363-374, 1988
    DOI:10.1002/jsfa.2740440409

    Williamson G, Edmondson DE, Müller F Oxidation-reduction potential studies on p-hydroxybenzoate hydroxylase from Pseudomonas fluorescens Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular 953 258-262, 1988
    DOI:10.1016/0167-4838(88)90033-7
    View abstract

    WILLIAMSON G, BEVERLEY MC THE PURIFICATION OF ACIDIC GLUTATHIONE S-TRANSFERASES FROM PEA-SEEDS AND THEIR ACTIVITY WITH LIPID-PEROXIDATION PRODUCTS BIOCHEMICAL SOCIETY TRANSACTIONS 15 1103-1104, 1987

    WILLIAMSON G, BALL SKM, COXON DT, CHAN HWS THE EFFECT OF SUBSTRATE METHYLATION AND OF DETERGENT ON THE REACTION OF PIG-LIVER GLUTATHIONE-S-TRANSFERASE WITH LINOLEATE HYDROPEROXIDES BIOCHEMICAL SOCIETY TRANSACTIONS 15 224-225, 1987

    WILLIAMSON G, BALL SKM, CHAN HWS THE PURIFICATION OF MULTIPLE FORMS OF GLUTATHIONE-S-TRANSFERASE FROM PIG-LIVER AND THEIR REACTION WITH INDIVIDUAL METHYL LINOLEATE HYDROPEROXIDES BIOCHEMICAL SOCIETY TRANSACTIONS 14 1278-1279, 1986

    EDMONDSON DE, BAKER KH, WILLIAMSON G, JACKSON K, GOLDSMITH DJ ANDROST-5-ENE-3-BETA-OL-17-BETA-SULFATE - A WATER-SOLUBLE SUBSTRATE FOR CHOLESTEROL OXIDASE FEDERATION PROCEEDINGS 45 1888-1888, 1986

    WATERS BW, ENGEL PC, WILLIAMSON G PHOTOINACTIVATION OF BUTYRYL-COA DEHYDROGENASE BIOCHEMICAL SOCIETY TRANSACTIONS 14 138-139, 1986

    EDMONDSON DE, WILLIAMSON G INFLUENCE OF THE SIDE-CHAIN PHOSPHATE ON THE BINDING OF REDUCED FLAVIN TO AZOTOBACTER APOFLAVODOXIN BIOPHYSICAL JOURNAL 49 A500-A500, 1986

    Williamson G, Edmondson DE [39]1H NMR Spectral Analysis of the Ribityl Side Chain of Riboflavin and its Ring-Substituted Analogs Methods in Enzymology 122 240-248, 1986
    DOI:10.1016/0076-6879(86)22177-1

    WILLIAMSON G, EDMONDSON DE H-1-NMR SPECTRAL-ANALYSIS OF THE RIBITYL SIDE-CHAIN OF RIBOFLAVIN AND ITS RING-SUBSTITUTED ANALOGS METHODS IN ENZYMOLOGY 122 240-248, 1986

    WILLIAMSON G, EDMONDSON DE PROTON NUCLEAR-MAGNETIC-RESONANCE STUDIES OF 8-ALPHA-N-IMIDAZOLYLRIBOFLAVIN IN ITS OXIDIZED AND REDUCED FORMS BIOCHEMISTRY 24 7918-7926, 1985
    DOI:10.1021/bi00348a011

    WILLIAMSON G, EDMONDSON DE EFFECT OF PH ON OXIDATION-REDUCTION POTENTIALS OF 8-ALPHA-N-IMIDAZOLE-SUBSTITUTED FLAVINS BIOCHEMISTRY 24 7790-7797, 1985
    DOI:10.1021/bi00347a043

    WILLIAMSON G, EDMONDSON DE H-1-NMR SPECTRAL-ANALYSIS OF THE RIBITYL SIDE-CHAIN OF VARIOUS RIBOFLAVIN ANALOGS FEDERATION PROCEEDINGS 44 1211-1211, 1985

    Williamson G, Edmondson DE 1H-NMR spectral analysis of the ribityl side chain of various riboflavin analogs Federation Proceedings 44 -, 1985

    Williamson G, Edmondson DE Influence of pH on the oxidation-reduction properties of 8α-imidazole-tetra-O-acetyl riboflavin Federation Proceedings 43 -, 1984

    WILLIAMSON G, ENGEL PC BUTYRYL-COA DEHYDROGENASE FROM MEGASPHAERA-ELSDENII - SPECIFICITY OF THE CATALYTIC REACTION BIOCHEMICAL JOURNAL 218 521-529, 1984

    WILLIAMSON G, ENGEL PC THE EFFECT ON BUTYRYL-COA DEHYDROGENASE OF REAGENTS SPECIFIC FOR NUCLEOPHILIC SULFUR BIOCHEMICAL JOURNAL 211 559-566, 1983

    WILLIAMSON G, ENGEL PC, NISHINA Y, SHIGA K A RESONANCE RAMAN-STUDY ON THE NATURE OF CHARGE-TRANSFER INTERACTIONS IN BUTYRYL COA DEHYDROGENASE FEBS LETTERS 138 29-32, 1982
    DOI:10.1016/0014-5793(82)80387-6

    WILLIAMSON G, ENGEL PC A CONVENIENT AND RAPID METHOD FOR THE COMPLETE REMOVAL OF COA FROM BUTYRYL-COA DEHYDROGENASE BIOCHIMICA ET BIOPHYSICA ACTA 706 245-248, 1982
    DOI:10.1016/0167-4838(82)90493-9

    WILLIAMSON G, ENGEL PC, MIZZER JP, THORPE C, MASSEY V EVIDENCE THAT THE GREENING LIGAND IN NATIVE BUTYRYL-COA DEHYDROGENASE IS A COA PERSULFIDE JOURNAL OF BIOLOGICAL CHEMISTRY 257 4314-4320, 1982

    Villa-Rodriguez J, Kerimi A, Abranko L, Williamson G German Chamomile (Matricaria chamomilla) Extract and Its Major Polyphenols Inhibit Intestinal alpha-glycosidases in vitro,

    Williamson G, Villa-Rodriguez J, Aydin E, Gauer J, Pyner A, Kerimi A Green and chamomile teas, but not acarbose, attenuate glucose and fructose transport via inhibition of GLUT2 and GLUT5 Molecular Nutrition and Food Research -,

    Williamson G, Kerimi A Differential impact of flavonoids on redox modulation, bioenergetics and cell signalling in normal and tumor cells: a comprehensive review" in its current form for publication in Antioxidants and Redox Signaling Antioxidants and Redox Signaling -,