School of Food Science and Nutrition

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Arwen Tyler

University of Leeds Academic Fellow
Research section: Food Colloids and Processing

Contact details

Room: E7.57
Tel: +44 (0)113 3431423
Email: A.I.I.Tyler@leeds.ac.uk

Keywords

Lipid biophysics
X-ray Scattering
Neutron Scattering
Lipid Nanoparticles
delivery vehicles/ delivery of bioactives
time-resolved Small Angle Scattering
high pressure

Photograph of Arwen Tyler

Research interests

Arwen joined the School of Food Science and Nutrition as a University Academic Fellow and Group Leader in September 2016, having previously been a PDRA and Fellow at Imperial College London.

Controlling the structure and out-of-equilibrium dynamics of soft matter systems is vitally important in a wide variety of critical research areas including the food and pharmaceutical industries. Despite the huge importance of this field, there remain significant barriers to its study, primarily the ability to control the size, shape and stability of soft matter systems and their dispersions, as well as triggering their structural evolution and time-resolved probing of dynamic structures.

My group is interested in the fundamental understanding of the self-assembly of lipids and their interactions with biomolecules from a soft condensed matter perspective. In particular, we are interested in:

  • Understanding the lipid molecular features that preferentially drive formation of various lipid phases or tune their size and to ultimately develop engineering rules to tailor these structures for particular biomedical and biotechnological applications.
  • Developing targeted and stimuli-responsive lipid nanocarriers for delivery of bioactives.
  • Investigating the kinetics and dynamics of structural transitions in soft matter systems with time-resolved techniques, using high pressure- or pH-jumps as a structural trigger to provide mechanistic and energetic insights.

We probe the equilibrium and dynamic phase behaviour of these systems using x-ray and neutron scattering, fluorescence spectroscopy, cryo-TEM, DSC, DLS and solid state NMR.

Publications

McCarthy NLC, Brooks NJ, Tyler AII, ElGamacy M, Welche PRL, Payne MC, Chau P-L A combined X-ray scattering and simulation study of halothane in membranes at raised pressures Chemical Physics Letters 671 21-27, 2017
DOI:10.1016/j.cplett.2016.12.041
View abstract

Bolognesi G, Saito Y, Tyler AII, Ward AD, Bain CD, Ces O Mechanical Characterization of Ultralow Interfacial Tension Oil-in-Water Droplets by Thermal Capillary Wave Analysis in a Microfluidic Device Langmuir 32 3580-3586, 2016
DOI:10.1021/acs.langmuir.5b04702
View abstract

Tyler AII, Barriga HMG, Parsons ES, McCarthy NLC, Ces O, Law RV, Seddon JM, Brooks NJ Electrostatic swelling of bicontinuous cubic lipid phases Soft Matter 11 3279-3286, 2015
DOI:10.1039/C5SM00311C
View abstract

Barriga HMG, Tyler AII, McCarthy NLC, Parsons ES, Ces O, Law RV, Seddon JM, Brooks NJ Temperature and pressure tuneable swollen bicontinuous cubic phases approaching nature's length scales Soft Matter 11 600-607, 2015
DOI:10.1039/C4SM02343A

Tyler AII, Law RV, Seddon JM X-ray diffraction of lipid model membranes In Methods in Membrane Lipids , 2014
DOI:10.1007/978-1-4939-1752-5_16

Tyler AII, Clarke JA, Seddon JM, Law RV Solid State NMR of Lipid Model Membranes In Methods in Membrane Lipids , 2014
DOI:10.1007/978-1-4939-1752-5_17

Turek VA, Elliott LN, Tyler AII, Demetriadou A, Paget J, Cecchini MP, Kucernak AR, Kornyshev AA, Edel JB Self-Assembly and Applications of Ultraconcentrated Nanoparticle Solutions ACS Nano 7 8753-8759, 2013
DOI:10.1021/nn403131e

Tyler AII, Shearman GC, Parsons ES, Barriga HMG, Templer RH, Ces O, Brooks NJ, Law RV, Seddon JM Tuning curvature in inverse micellar and bicontinuous cubic phases EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS 42 , 2013

Tyler AII, Law RV, Seddon JM Fatty Acids, Alkanols, and Diacylglycerols In Encyclopedia of Biophysics , 2013
DOI:10.1007/978-3-642-16712-6_532

Tyler AII, Shearman GC, Brooks NJ, Delacroix H, Law RV, Templer RH, Ces O, Seddon JM Hydrostatic pressure effects on a hydrated lipid inverse micellar Fd3m cubic phase Phys. Chem. Chem. Phys. 13 3033-3038, 2011
DOI:10.1039/C0CP01783C

Shearman GC, Tyler AII, Brooks NJ, Templer RH, Ces O, Law RV, Seddon JM Ordered micellar and inverse micellar lyotropic phases Liquid Crystals 37 679-694, 2010
DOI:10.1080/02678292.2010.484917

Tyler AII, Shearman GC, Brooks NJ, Templer RH, Ces O, Law RV, Seddon JM High Pressure Static and Time-Resolved X-Ray Studies of Inverse Phases in Cholesterol / Lipid Mixtures Biophysical Journal 98 231a-231a, 2010
DOI:10.1016/j.bpj.2009.12.1252

Shearman GC, Tyler AII, Brooks NJ, Templer RH, Ces O, Law RV, Seddon JM A 3-D Hexagonal Inverse Micellar Lyotropic Phase Journal of the American Chemical Society 131 1678-1679, 2009
DOI:10.1021/ja809280r