School of Food Science and Nutrition

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Elena Simone

Lecturer in Remote Sensing
Research section: Food Colloids and Processing

Contact details

Room: E7.57
Tel: +44 (0)113 3431424
Email: E.Simone@leeds.ac.uk

Keywords

Process Analytical Technology (PAT)
Crystallisation
Remote Sensing
Quality by Design


Photograph of Elena Simone

Research interests

Elena Simone graduated with an MSc in Chemical Engineering from the University of Pisa (Italy) and then moved to Loughborough University (UK) to study for a PhD in the Department of Chemical Engineering. After obtaining her doctorate degree she stayed in the same institution for a postdoc. Elena joined the School of Food Science and Nutrition at the University of Leeds in September 2016 as Lecturer in Remote Sensing.

Her research interests include:
  • Understanding the phenomena of polymorphism, nucleation and crystal growth of pharmaceuticals and food crystals (e.g. fats, sugars) using on-line, in situ, analytical techniques as well as off-line solid state characterisation;
  • Developing strategies to effectively control crystal size, shape and polymorphism during crystallisation processes combining experimental and modelling work (Population Balance Equations);
  • Exploring novel technology and non-invasive techniques for food safety and reassurance;
  • Application of Process Analytical Technology (PAT) tools and Quality by Design (QbD) in the food industry.

Publications

Hansen TB, Simone E, Nagy Z, Qu H Process Analytical Tools to control polymorphism and particle size in batch crystallization processes Organic Process Research&Development 21 855-865, 2017
DOI:10.1021/acs.oprd.7b00087
View abstract

Simone E, Klapwijk AR, Wilson CC, Nagy ZK Investigation of the Evolution of Crystal Size and Shape during Temperature Cycling and in the Presence of a Polymeric Additive Using Combined Process Analytical Technologies Crystal Growth and Design 17 1695-1706, 2017
DOI:10.1021/acs.cgd.6b01683
View abstract

Klapwijk AR, Simone E, Nagy ZK, Wilson CC Tuning Crystal Morphology of Succinic Acid Using a Polymer Additive Crystal Growth and Design 16 4349-4359, 2016
DOI:10.1021/acs.cgd.6b00465
View abstract

Abioye AO, Chi GT, Simone E, Nagy Z Real-time monitoring of the mechanism of ibuprofen-cationic dextran crystanule formation using crystallization process informatics system (CryPRINS) International Journal of Pharmaceutics 509 264-278, 2016
DOI:10.1016/j.ijpharm.2016.05.066
View abstract

Simone E, Cenzato MV, Nagy ZK A study on the effect of the polymeric additive HPMC on morphology and polymorphism of ortho-aminobenzoic acid crystals Journal of Crystal Growth 446 50-59, 2016
DOI:10.1016/j.jcrysgro.2016.04.034
View abstract

Simone E, Zhang W, Nagy ZK Analysis of the crystallization process of a biopharmaceutical compound in the presence of impurities using process analytical technology (PAT) tools Journal of Chemical Technology and Biotechnology 91 1461-1470, 2016
DOI:10.1002/jctb.4743
View abstract

Simone E, McVeigh J, Nagy ZK, Reis NM Application of a multiplex microfluidic platform to fast polymorph screening of pharmaceutical compounds 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 , 2016
View abstract

Simone E, Steele G, Nagy ZK Tailoring crystal shape and polymorphism using combinations of solvents and a structurally related additive CrystEngComm 17 9370-9379, 2015
DOI:10.1039/c5ce01878a
View abstract

Simone E, Nagy ZK A link between the ATR-UV/Vis and Raman spectra of zwitterionic solutions and the polymorphic outcome in cooling crystallization CrystEngComm 17 6538-6547, 2015
DOI:10.1039/c5ce00702j
View abstract

Simone E, Zhang W, Nagy ZK Application of process analytical technology-based feedback control strategies to improve purity and size distribution in biopharmaceutical crystallization Crystal Growth and Design 15 2908-2919, 2015
DOI:10.1021/acs.cgd.5b00337
View abstract

Simone E, Saleemi AN, Nagy ZK In situ monitoring of polymorphic transformations using a composite sensor array of Raman, NIR, and ATR-UV/vis spectroscopy, FBRM, and PVM for an intelligent decision support system Organic Process Research and Development 19 167-177, 2015
DOI:10.1021/op5000122
View abstract

Simone E, Zhang W, Nagy ZK Improving purity and size distribution in biopharmaceutical crystallization using pat-based feedback control strategies Pharmaceutical Discovery, Development and Manufacturing Forum 2015 - Core Programming Area at the 2015 AIChE Annual Meeting , 2015

Simone E, Borsos A, Nagy ZK Application of raman and ATR-UV/Vis spectroscopy for a model-free and model-based active polymorphic feedback control of crystallization processes Separations Division 2015 - Core Programming Area at the 2015 AIChE Annual Meeting 2 , 2015

Simone E, Steele G, Nagy ZK Tailoring polymorphism of ortho-aminobenzoic acid(OABA) using combinations of several solvents and a structurally related additive Separations Division 2015 - Core Programming Area at the 2015 AIChE Annual Meeting 2 , 2015

Simone E, Steele G, Cenzato MV, Nagy ZK Controlling morphology and polymorphism of a zwitterionic compound (OABA) using different types of additives and solvents Liaison Functions 2015 - Core Programming Area at the 2015 AIChE Annual Meeting , 2015

Simone E, Saleemi AN, Tonnon N, Nagy ZK Active polymorphic feedback control of crystallization processes using a combined raman and ATR-UV/Vis spectroscopy approach Crystal Growth and Design 14 1839-1850, 2014
DOI:10.1021/cg500017a
View abstract

Simone E, Saleemi AN, Nagy ZK Raman, UV, NIR, and Mid-IR Spectroscopy with Focused Beam Reflectance Measurement in Monitoring Polymorphic Transformations Chemical Engineering and Technology 37 1305-1313, 2014
DOI:10.1002/ceat.201400203
View abstract

Simone E, Saleemi AN, Nagy ZK Application of quantitative Raman spectroscopy for the monitoring of polymorphic transformation in crystallization processes using a good calibration practice procedure Chemical Engineering Research and Design 92 594-611, 2014
DOI:10.1016/j.cherd.2013.11.004
View abstract

Simone E, Szilagyi B, Nagy ZK Systematic model identification and optimization-based active polymorphic control of crystallization processes Chemical Engineering Science -,
DOI:10.1016/j.ces.2017.09.034
View abstract