School of Food Science and Nutrition

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Alan Mackie

Head of the School of Food Science and Nutrition
Professor of Colloids Chemistry
Research section: Food Colloids and Processing

Contact details

Room: 1.22
Tel: +44 (0)113 3432959
Email: A.R.Mackie@leeds.ac.uk

Keywords







Photograph of Alan Mackie

Research interests

Alan Mackie is Professor of Colloid Chemistry in the Department, appointed in September 2016 after a career based at the Institute of Food Research in Norwich. Alan's principal research interest is in tailoring of food structures for improved health benefits. This involves research in the following areas:

  • Using processing and formulation of dairy based protein systems to control nutrient release and regulate satiety.
  • Investigating the role of fibre in the upper GI tract including interactions with bile acids, as a potential agent to alter intestinal mucus permeability and alter the transport of food components into the colon.

The laboratory is in the process of being equipped for this work with various specialist pieces of equipment including: interfacial rheometers, surface tension apparatus and both static and semi-dynamic simulations of upper gastrointestinal digestion. In addition we will have the capability to fully analyse the products of digestion as well as assess their interactions with the intestinal mucosa.

Alan has worked with a wide range of UK sponsors including UK research councils, EU and other international funding agencies and in collaboration with a number of large national and international food companies. Potential visitors are very welcome to discuss related projects, funded for example via UK Research Councils (BBSRC and EPSRC) the European Union (e.g., EU Marie Curie schemes) or the Royal Society, etc.

Publications

Mackie AR, Bajka BH, Rigby NM, Wilde PJ, Alves-Pereira F, Mosleth EF, Rieder A, Kirkhus B, Salt LJ Oatmeal particle size alters glycemic index but not as a function of gastric emptying rate. Am J Physiol Gastrointest Liver Physiol 313 G239-G246, 2017
DOI:10.1152/ajpgi.00005.2017
View abstract

Fotschki B, Juśkiewicz J, Jurgoński A, Rigby N, Sójka M, Kołodziejczyk K, Mackie AR, Zduńczyk Z Raspberry pomace alters cecal microbial activity and reduces secondary bile acids in rats fed a high-fat diet Journal of Nutritional Biochemistry 46 13-20, 2017
DOI:10.1016/j.jnutbio.2017.03.004
View abstract

Bohn T, Carriere F, Day L, Deglaire A, Egger L, Freitas D, Golding M, Le Feunteun S, Macierzanka A, Menard O, Miralles B, Moscovici A, Portmann R, Recio I, Rémond D, Santé-Lhoutelier V, Wooster TJ, Lesmes U, Mackie AR, Dupont D Correlation between in vitro and in vivo data on food digestion. What can we predict with static in vitro digestion models? Crit Rev Food Sci Nutr 1-23, 2017
DOI:10.1080/10408398.2017.1315362
View abstract

Ferreira-Lazarte A, Montilla A, Mulet-Cabero A-I, Rigby N, Olano A, Mackie A, Villamiel M Study on the digestion of milk with prebiotic carbohydrates in a simulated gastrointestinal model Journal of Functional Foods 33 149-154, 2017
DOI:10.1016/j.jff.2017.03.031
View abstract

Mulet-Cabero A-I, Rigby NM, Brodkorb A, Mackie AR Dairy food structures influence the rates of nutrient digestion through different in vitro gastric behaviour Food Hydrocolloids 67 63-73, 2017
DOI:10.1016/j.foodhyd.2016.12.039
View abstract

Thorning TK, Bertram HC, Bonjour J-P, de Groot L, Dupont D, Feeney E, Ipsen R, Lecerf JM, Mackie A, McKinley MC, Michalski M-C, Rémond D, Risérus U, Soedamah-Muthu SS, Tholstrup T, Weaver C, Astrup A, Givens I Whole dairy matrix or single nutrients in assessment of health effects: current evidence and knowledge gaps The American Journal of Clinical Nutrition 105 1033-1045, 2017
DOI:10.3945/ajcn.116.151548
View abstract

Romano A, Mackie A, Farina F, Aponte M, Sarghini F, Masi P Characterisation, in vitro digestibility and expected glycemic index of commercial starches as uncooked ingredients. J Food Sci Technol 53 4126-4134, 2016
DOI:10.1007/s13197-016-2375-9
View abstract

Egger L, Mà nard O, Delgado-Andrade C, Alvito P, Assunà à o R, Balance S, Barberà R, Brodkorb A, Cattenoz T, Clemente A, Comi I, Dupont D, Garcia-Llatas G, Lagarda MJ, Le Feunteun S, JanssenDuijghuijsen L, Karakaya S, Lesmes U, Mackie AR, Martins C, Meynier A, Miralles B, Murray BS, Pihlanto A, PicarielloG, Santos CN, Simsek S, Recio I, Rigby N, Rioux LE, Stoffers H, Tavares A, Tavares L, Turgeon S, Ulleberg EK, Vegarud GE, Vergà res G, Portmann R The harmonized INFOGEST in vitro digestion method: From knowledge to action Food Research International 88 217-225, 2016
DOI:10.1016/j.foodres.2015.12.006
View abstract

Mackie AR, Rigby N, Harvey P, Bajka B Increasing dietary oat fibre decreases the permeability of intestinal mucus Journal of Functional Foods 26 418-427, 2016
DOI:10.1016/j.jff.2016.08.018
View abstract

Mackie A, Ferranti P, Dupont D The 4th International Conference on Food Digestion Food Research International 88 179-180, 2016
DOI:10.1016/j.foodres.2016.08.043

Mackie A, Bajka B, Rigby N Roles for dietary fibre in the upper GI tract: The importance of viscosity Food Research International 88 234-238, 2016
DOI:10.1016/j.foodres.2015.11.011
View abstract

Grundy MM-L, Edwards CH, Mackie AR, Gidley MJ, Butterworth PJ, Ellis PR Re-evaluation of the mechanisms of dietary fibre and implications for macronutrient bioaccessibility, digestion and postprandial metabolism. Br J Nutr 116 816-833, 2016
DOI:10.1017/S0007114516002610
View abstract

Abdullah SU, Alexeev Y, Johnson PE, Rigby NM, Mackie AR, Dhaliwal B, Mills ENC Ligand binding to an Allergenic Lipid Transfer Protein Enhances Conformational Flexibility resulting in an Increase in Susceptibility to Gastroduodenal Proteolysis. Sci Rep 6 30279-, 2016
DOI:10.1038/srep30279
View abstract

Di Silvio D, Rigby N, Bajka B, Mackie A, Baldelli Bombelli F Effect of protein corona magnetite nanoparticles derived from bread in vitro digestion on Caco-2 cells morphology and uptake. Int J Biochem Cell Biol 75 212-222, 2016
DOI:10.1016/j.biocel.2015.10.019
View abstract

Xepapadaki P, Fiocchi A, Grabenhenrich L, Roberts G, Grimshaw KEC, Fiandor A, Larco JI, Sigurdardottir S, Clausen M, Papadopoulos NG, Dahdah L, Mackie A, Sprikkelman AB, Schoemaker AA, Dubakiene R, Butiene I, Kowalski ML, Zeman K, Gavrili S, Keil T, Beyer K Incidence and natural history of hen's egg allergy in the first 2 years of life-the EuroPrevall birth cohort study. Allergy 71 350-357, 2016
DOI:10.1111/all.12801
View abstract

Avgidou M, Dimopoulou M, Mackie AR, Rigby NM, Ritzoulis C, Panayiotou C Physicochemical aspects of mucosa surface RSC Advances 6 102634-102646, 2016
DOI:10.1039/c6ra23051b
View abstract

Mackie AR, Macierzanka A, Aarak K, Rigby NM, Parker R, Channell GA, Harding SE, Bajka BH Sodium alginate decreases the permeability of intestinal mucus. Food Hydrocoll 52 749-755, 2016
DOI:10.1016/j.foodhyd.2015.08.004
View abstract

Grundy MML, Carrière F, Mackie AR, Gray DA, Butterworth PJ, Ellis PR The role of plant cell wall encapsulation and porosity in regulating lipolysis during the digestion of almond seeds. Food Funct 7 69-78, 2016
DOI:10.1039/c5fo00758e
View abstract

Almutairi FM, Cifre J-GH, Adams GG, Kök MS, Mackie AR, de la Torre JG, Harding SE Application of recent advances in hydrodynamic methods for characterising mucins in solution. Eur Biophys J 45 45-54, 2016
DOI:10.1007/s00249-015-1075-0
View abstract

Bajka BH, Rigby NM, Cross KL, Macierzanka A, Mackie AR The influence of small intestinal mucus structure on particle transport ex vivo. Colloids Surf B Biointerfaces 135 73-80, 2015
DOI:10.1016/j.colsurfb.2015.07.038
View abstract

Juvonen KR, Macierzanka A, Lille ME, Laaksonen DE, Mykkänen HM, Niskanen LK, Pihlajamäki J, Mäkelä KA, Mills CEN, Mackie AR, Malcolm P, Herzig K-H, Poutanen KS, Karhunen LJ Cross-linking of sodium caseinate-structured emulsion with transglutaminase alters postprandial metabolic and appetite responses in healthy young individuals. Br J Nutr 114 418-429, 2015
DOI:10.1017/S0007114515001737
View abstract

Di Silvio D, Rigby N, Bajka B, Mayes A, Mackie A, Baldelli Bombelli F Technical tip: high-resolution isolation of nanoparticle-protein corona complexes from physiological fluids. Nanoscale 7 11980-11990, 2015
DOI:10.1039/c5nr02618k
View abstract

Mamone G, Nitride C, Picariello G, Addeo F, Ferranti P, Mackie A Tracking the fate of pasta (T. Durum semolina) immunogenic proteins by in vitro simulated digestion. J Agric Food Chem 63 2660-2667, 2015
DOI:10.1021/jf505461x
View abstract

Le T-M, van Hoffen E, Kummeling I, Potts J, Ballmer-Weber BK, Bruijnzeel-Koomen CA, Lebens AF, Lidholm J, Lindner TM, Mackie A, Mills EC, van Ree R, Vieths S, Fernández-Rivas M, Burney PG, Knulst AC Food allergy in the Netherlands: differences in clinical severity, causative foods, sensitization and DBPCFC between community and outpatients. Clin Transl Allergy 5 8-, 2015
DOI:10.1186/s13601-015-0051-1
View abstract

Mackie AR, Goycoolea FM, Menchicchi B, Caramella CM, Saporito F, Lee S, Stephansen K, Chronakis IS, Hiorth M, Adamczak M, Waldner M, Nielsen HM, Marcelloni L Innovative Methods and Applications in Mucoadhesion Research. Macromolecular Bioscience -,
DOI:10.1002/mabi.201600534
View abstract

Mackie A Food: More than the sum of its parts Current Opinion in Food Science -,
DOI:10.1016/j.cofs.2017.07.004
View abstract