School of Food Science and Nutrition

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Francisco Goycoolea

Chair in Biopolymers
Research section: Food Chemistry and Biochemistry

Contact details

Room: E7.59
Tel: +44 (0)113 3431412
Email: F.M.Goycoolea@leeds.ac.uk

Keywords

Food biopolymers
Polysaccharides
Self-assembly
Nanostructured soft materials
Biological networks
Bacterial quorum sensing
Biofilms
Functional foods
Phytochemicals

Photograph of Francisco Goycoolea

Research interests

My field of scientific expertise is in Biopolymer Science and Food Nanobiotechnology. My focus of interest in the last years has been on soft nanostructured biomaterials derived from natural polymers, namely polysaccharides and proteins (e.g., hydrogels, polyelectrolyte complexes, colloidal micro- and nanoparticles). The self-assembly processes underpinning the structure of these systems at the molecular and supramolecular scales can be used as a blueprint for the rational design of novel functional, "smart" food materials. I am particularly interested in elucidating the mechanisms of interaction of these materials with mammalian and bacterial cells and on their influence on critical processes known to operate in physical and communication life networks (e.g., mucosa, epithelia, biofilms). This understanding underpins the rational design of novel systems for food and health applications.

More specifically, our areas of interest include:

  • Structure-function relationships that determine the biophysical and biological properties of biopolymer-based soft material (namely, core-shell nano- and microparticles, gels, etc.) and their interactions in vitro with biological barriers and biological networks (namely, mucosa, epithelia, bacterial biofilms).
  • Loading of natural bioactive payloads into biopolymer-based materials, intending to modifying their biological and sensory profile (e.g., mouthfeel, flavour release, pungency), and enhance their oral bioavailability and thus their health/therapeutic benefits. Bioactive compounds of interest include both, low molecular weight phytochemicals (e.g. flavonoids, capsaicinoids, flavours) and non-Lipinsky biologicals (like peptides, proteins, nucleic acids and enzymes).
  • Microfabrication technologies (e.g., microfluidics) that enable novel ways of producing and studying the interactions between food materials and cells and bacteria in 3-D single-cell culture that recreate their natural microenvironment.
  • Top-down and bottom-up approaches to the development of innovative functional food products for the vegetarian and vegan niche market.
  • Development of antibiotic-free therapies against bacterial pathogen relevant to food, aquaculture and health. We pursue two approaches in this direction. One is to disrupt quorum sensing (QS) processes of pathogenic bacteria and thus exert control on their virulence responses (e.g., biofilm formation) using biopolymer-based nanoparticles. The other one involves specific polysaccharides as bioactive components of emulsions that exhibit antiadhesion activity against bacteria such as Helicobacter pylori or uropathogenic E. coli (Menchicchi et al. Curr. Pharm. Design 21(33): 4888-4906 http://doi.org/10.2174/1381612821666150820104028). These strategies seek novel routes to deal with antimicrobial resistance by "superbugs".
  • Surface-modification of nanomaterials by functionalization with recombinant proteins or aptamers. This approach is sought as a strategy to confer labelling and targeting properties to different types of nanosystems that enable to image them in mammalian cells by using confocal laser scanning microscopy (CLSM) (Fuenzalida et al. 2014, Biomacromolecules 15: 2532-2539. http://doi.org/10.1021/bm500394v).
  • In silico simulations of nanomaterial behaviour and other critical phenomena in living systems. Agent-based models are currently developed to simulate the bacterial quorum sensing response and the interaction between bacteria and nanoparticles (Vila-Sanjurjo et al. 2016 biorXiv http://doi.org/10.1101/074369: Qin et al. Colloids and Surfaces B: Biointerfaces.149, 358-368. http://doi.org/10.1016/j.colsurfb.2016.10.031

Publications

Mendes AC, Strohmenger T, Goycoolea F, Chronakis IS Electrostatic self-assembly of polysaccharides into nanofibers Colloids and Surfaces A: Physicochemical and Engineering Aspects 531 182-188, 2017
DOI:10.1016/j.colsurfa.2017.07.044
View abstract

Maciel VBV, Yoshida CMP, Pereira SMSS, Goycoolea FM, Franco TT Electrostatic Self-Assembled Chitosan-Pectin Nano- and Microparticles for Insulin Delivery. Molecules (Basel, Switzerland) 22 -, 2017
DOI:10.3390/molecules22101707
View abstract

Caro Leon FJ, Lizardi-Mendoza J, Arguelles-Monal W, Carvajal-Millan E, Lopez Franco YL, Goycoolea FM Supercritical CO2 dried chitosan nanoparticles: production and characterization RSC ADVANCES 7 30879-30885, 2017
DOI:10.1039/c7ra02555f

Qin X, Engwer C, Desai S, Vila-Sanjurjo C, Goycoolea FM An investigation of the interactions between an E. coli bacterial quorum sensing biosensor and chitosan-based nanocapsules Colloids and Surfaces B: Biointerfaces 149 358-368, 2017
DOI:10.1016/j.colsurfb.2016.10.031
View abstract

Luque-Alcaraz AG, Lizardi-Mendoza J, Goycoolea FM, Higuera-Ciapara I, Argüelles-Monal W Preparation of chitosan nanoparticles by nanoprecipitation and their ability as a drug nanocarrier RSC Advances 6 59250-59256, 2016
DOI:10.1039/C6RA06563E
View abstract

Fernández Fernández E, Santos-Carballal B, Weber WM, Goycoolea FM Chitosan as a non-viral co-transfection system in a cystic fibrosis cell line. International Journal of Pharmaceutics 502 1-9, 2016
DOI:10.1016/j.ijpharm.2016.01.083
View abstract

Kaiser M, Chalapala S, Gorzelanny C, Perali RS, Goycoolea FM The Effect of Capsaicin Derivatives on Tight-Junction Integrity and Permeability of Madin-Darby Canine Kidney Cells Journal of Pharmaceutical Sciences 105 630-638, 2016
DOI:10.1016/j.xphs.2015.10.017
View abstract

Fuenzalida JP, Nareddy PK, Moreno-Villoslada I, Moerschbacher BM, Swamy MJ, Pan S, Ostermeier M, Goycoolea FM On the role of alginate structure in complexing with lysozyme and application for enzyme delivery FOOD HYDROCOLLOIDS 53 239-248, 2016
DOI:10.1016/j.foodhyd.2015.04.017

Santos-Carballal B, Swamy MJ, Moerschbacher BM, Goycoolea FM SYBR Gold Fluorescence Quenching is a Sensitive Probe of Chitosan-microRNA Interactions JOURNAL OF FLUORESCENCE 26 37-42, 2016
DOI:10.1007/s10895-015-1697-8

Omwenga EO, Hensel A, Shitandi A, Goycoolea FM Ethnobotanical survey of traditionally used medicinal plants for infections of skin, gastrointestinal tract, urinary tract and the oral cavity in Borabu sub-county, Nyamira county, Kenya JOURNAL OF ETHNOPHARMACOLOGY 176 508-514, 2015
DOI:10.1016/j.jep.2015.11.032

Fernandez-Quiroz D, Gonzalez-Gomez A, Lizardi-Mendoza J, Vazquez-Lasa B, Goycoolea FM, San Roman J, Argueelles-Monal WM Effect of the molecular architecture on the thermosensitive properties of chitosan-g-poly(N-vinylcaprolactam) CARBOHYDRATE POLYMERS 134 92-101, 2015
DOI:10.1016/j.carbpol.2015.07.069

Kleine-Brueggeney H, Zorzi GK, Fecker T, El Gueddari NE, Moerschbacher BM, Goycoolea FM A rational approach towards the design of chitosan-based nanoparticles obtained by ionotropic gelation COLLOIDS AND SURFACES B-BIOINTERFACES 135 99-108, 2015
DOI:10.1016/j.colsurfb.2015.07.016

Kaiser M, Kirsch B, Hauser H, Schneider D, Seuß-Baum I, Goycoolea FM In Vitro and Sensory Evaluation of Capsaicin-Loaded Nanoformulations PLOS ONE -, 2015
DOI:10.1371/journal.pone.0141017
View abstract

Montiel-Herrera M, Gandini A, Goycoolea FM, Jacobsen NE, Lizardi-Mendoza J, Recillas-Mota M, Argueelles-Monal WM N-(furfural) chitosan hydrogels based on Diels-Alder cycloadditions and application as microspheres for controlled drug release CARBOHYDRATE POLYMERS 128 220-227, 2015
DOI:10.1016/j.carbpol.2015.03.052

Santos-Carballal B, Aaldering LJ, Ritzefeld M, Pereira S, Sewald N, Moerschbacher BM, Goette M, Goycoolea FM Physicochemical and biological characterization of chitosan-microRNA nanocomplexes for gene delivery to MCF-7 breast cancer cells SCIENTIFIC REPORTS 5 -, 2015
DOI:10.1038/srep13567

Kaiser M, Pereira S, Pohl L, Ketelhut S, Kemper B, Gorzelanny C, Galla H-J, Moerschbacher BM, Goycoolea FM Chitosan encapsulation modulates the effect of capsaicin on the tight junctions of MDCK cells Scientific Reports 5 -, 2015
DOI:10.1038/srep10048
View abstract

Stephansen K, Mattebjerg M, Wattjes J, Milisavljevic A, Jessen F, Qvortrup K, Goycoolea FM, Chronakis IS Design and characterization of self-assembled fish sarcoplasmic protein-alginate nanocomplexes INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 76 146-152, 2015
DOI:10.1016/j.ijbiomac.2015.02.018

Menchicchi B, Fuenzalida JP, Hensel A, Swamy MJ, David L, Rochas C, Goycoolea FM Biophysical Analysis of the Molecular Interactions between Polysaccharides and Mucin Biomacromolecules 16 924-935, 2015
DOI:10.1021/bm501832y
View abstract

Escobedo-Lozano AY, Domard A, Velázquez CA, Goycoolea FM, Argüelles-Monal WM Physical properties and antibacterial activity of chitosan/acemannan mixed systems Carbohydrate Polymers 115 707-714, 2015
DOI:10.1016/j.carbpol.2014.07.064
View abstract

Fuenzalida JP, Goycoolea FM Polysaccharide-Protein Nanoassemblies: Novel Soft Materials for Biomedical and Biotechnological Applications CURRENT PROTEIN&PEPTIDE SCIENCE 16 89-99, 2015

Menchicchi B, Hensel A, Goycoolea FM Polysaccharides as Bacterial Antiadhesive Agents and "Smart" Constituents for Improved Drug Delivery Systems Against Helicobacter pylori Infection CURRENT PHARMACEUTICAL DESIGN 21 4888-4906, 2015
DOI:10.2174/1381612821666150820104028

Menchicchi B, Fuenzalida JP, Bobbili KB, Hensel A, Swamy MJ, Goycoolea FM Structure of Chitosan determines its interactions with mucin Biomacromolecules 15 3550-3558, 2014
DOI:10.1021/bm5007954
View abstract

Fuenzalida JP, Flores ME, Móniz I, Feijoo M, Goycoolea F, Nishide H, Moreno-Villoslada I Immobilization of hydrophilic low molecular-weight molecules in nanoparticles of chitosan/poly(sodium 4-styrenesulfonate) assisted by aromatic-aromatic interactions Journal of Physical Chemistry B 118 9782-9791, 2014
DOI:10.1021/jp5037553
View abstract

Fuenzalida JP, Weikert T, Hoffmann S, Vila-Sanjurjo C, Moerschbacher BM, Goycoolea FM, Kolkenbrock S Affinity protein-based FRET tools for cellular tracking of chitosan nanoparticles and determination of the polymer degree of acetylation Biomacromolecules 15 2532-2539, 2014
DOI:10.1021/bm500394v
View abstract

Marcial G, Messing J, Menchicchi B, Goycoolea FM, Faller G, Graciela FDV, Hensel A Effects of polysaccharide isolated from Streptococcus thermophilus CRL1190 on human gastric epithelial cells International Journal of Biological Macromolecules 62 217-224, 2013
DOI:10.1016/j.ijbiomac.2013.08.011
View abstract

Vila-Sanjurjo C, Fuenzalida JP, Menchicchi B, Engwer C, Hoffman S, Pereira S, Remunan-Lopez C, Alonso MJ, Vidal A, Moerschbacher BM, Kollenbrock S, Fetzner S, Philipp B, Goycoolea FM Chitosan-based nanomaterials for drug delivery and antibiotic-free bacterial control Technical Proceedings of the 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013 3 , 2013
View abstract

Fuenzalida JP, Pavan KN, Moreno-Villoslada I, Moerschbacher B, Swamy MJ, Pan S, Ostermaier M, Goycoolea FM Lysozyme - Alginate nanocomplex: The role of alginate composition Technical Proceedings of the 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013 3 , 2013
View abstract

Trapani A, Di Gioia S, Ditaranto N, Cioffi N, Goycoolea FM, Carbone A, Garcia-Fuentes M, Conese M, Alonso MJ Systemic heparin delivery by the pulmonary route using chitosan and glycol chitosan nanoparticles International Journal of Pharmaceutics 447 115-123, 2013
DOI:10.1016/j.ijpharm.2013.02.035
View abstract

Luque-Alcaraz AG, Lizardi J, Goycoolea FM, Valdez MA, Acosta AL, Iloki-Assanga SB, Higuera-Ciapara I, Argüelles-Monal W Characterization and antiproliferative activity of nobiletin-loaded chitosan nanoparticles Journal of Nanomaterials 2012 -, 2012
DOI:10.1155/2012/265161
View abstract

Goycoolea FM, Valle-Gallego A, Stefani R, Menchicchi B, David L, Rochas C, Santander-Ortega MJ, Alonso MJ Chitosan-based nanocapsules: Physical characterization, stability in biological media and capsaicin encapsulation Colloid and Polymer Science 290 1423-1434, 2012
DOI:10.1007/s00396-012-2669-z
View abstract

López-Franco YL, Córdova-Moreno RE, Goycoolea FM, Valdez MA, Juárez-Onofre J, Lizardi-Mendoza J Classification and physicochemical characterization of mesquite gum (Prosopis spp.) Food Hydrocolloids 26 159-166, 2012
DOI:10.1016/j.foodhyd.2011.05.006
View abstract

Pastor E, Matveeva E, Valle-Gallego A, Goycoolea FM, Garcia-Fuentes M Protein delivery based on uncoated and chitosan-coated mesoporous silicon microparticles Colloids and Surfaces B: Biointerfaces 88 601-609, 2011
DOI:10.1016/j.colsurfb.2011.07.049
View abstract

Oyarzun-Ampuero FA, Goycoolea FM, Torres D, Alonso MJ A new drug nanocarrier consisting of polyarginine and hyaluronic acid European Journal of Pharmaceutics and Biopharmaceutics 79 54-57, 2011
DOI:10.1016/j.ejpb.2011.04.008
View abstract

Recillas M, Silva LL, Peniche C, Goycoolea FM, Rinaudo M, Román JS, Argüelles-Monal WM Thermo- and pH-responsive polyelectrolyte complex membranes from chitosan-g-N-isopropylacrylamide and pectin Carbohydrate Polymers 86 1336-1343, 2011
DOI:10.1016/j.carbpol.2011.06.047
View abstract

Rosas-Durazo A, Lizardi J, Higuera-Ciapara I, Argüelles-Monal W, Goycoolea FM Development and characterization of nanocapsules comprising dodecyltrimethylammonium chloride andκ-carrageenan Colloids and Surfaces B: Biointerfaces 86 242-246, 2011
DOI:10.1016/j.colsurfb.2011.03.020
View abstract

Navarro-Verdugo AL, Goycoolea FM, Romero-Meléndez G, Higuera-Ciapara I, Argüelles-Monal W A modified Boltzmann sigmoidal model for the phase transition of smart gels Soft Matter 7 5847-5853, 2011
DOI:10.1039/c1sm05252g
View abstract

Goycoolea FM, Fernández-Valle ME, Aranaz I, Heras A PH- and temperature-sensitive chitosan hydrogels: Swelling and MRI studies Macromolecular Chemistry and Physics 212 887-895, 2011
DOI:10.1002/macp.201000301
View abstract

Básaca-Loya GA, Burboa MG, Álvarez ME, Gutiérrez-Millán LE, Goycoolea FM, Valdez MA Interfacial properties of B phycoerythrin extracted from the red microalga Rhodosorus marinus at hexadecane-water and air-water interfaces Science of Advanced Materials 3 259-268, 2011
DOI:10.1166/sam.2011.1152
View abstract

Rosas-Durazo A, Hernández J, Lizardi J, Higuera-Ciapara I, Goycoolea FM, Argüelles-Monal W Gelation processes in the non-stoichiometric polylectrolyte-surfactant complex betweenκ-carrageenan and dodecyltrimethylammonium chloride in KCl Soft Matter 7 2103-2112, 2011
DOI:10.1039/c0sm00663g
View abstract

Santander-Ortega MJ, Peula-García JM, Goycoolea FM, Ortega-Vinuesa JL Chitosan nanocapsules: Effect of chitosan molecular weight and acetylation degree on electrokinetic behaviour and colloidal stability Colloids and Surfaces B: Biointerfaces 82 571-580, 2011
DOI:10.1016/j.colsurfb.2010.10.019
View abstract

Goycoolea FM, Lollo G, Remuñán-López C, Quaglia F, Alonso MJ Chitosan-alginate blended nanoparticles as carriers for the transmucosal delivery of macromolecules Biomacromolecules 10 1736-1743, 2009
DOI:10.1021/bm9001377
View abstract

Recillas M, Silva LL, Peniche C, Goycoolea FM, Rinaudo M, Argüelles-Monal WM Thermoresponsive behavior of chitosan-g-N-isopropylacrylamide copolymer solutions Biomacromolecules 10 1633-1641, 2009
DOI:10.1021/bm9002317
View abstract

González-Aguilar GA, Valenzuela-Soto E, Lizardi-Mendoza J, Goycoolea F, Martínez-Téllez MA, Villegas-Ochoa MA, Monroy-García IN, Ayala-Zavala JF Effect of chitosan coating in preventing deterioration and preserving the quality of fresh-cut papaya 'Maradol' Journal of the Science of Food and Agriculture 89 15-23, 2009
DOI:10.1002/jsfa.3405
View abstract

Peniche Covas CA, Argüelles-Monal W, Goycoolea FM Chitin and chitosan: Major sources, properties and applications In Monomers, Polymers and Composites from Renewable Resources , 2008
DOI:10.1016/B978-0-08-045316-3.00025-9
View abstract

Galed G, Diaz E, Goycoolea FM, Heras A Influence of N-deacetylation conditions on chitosan production fromα-chitin Natural Product Communications 3 543-550, 2008
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López-Franco YL, Calderón de la Barca AM, Valdez MA, Peter MG, Rinaudo M, Chambat G, Goycoolea FM Structural characterization of mesquite (Prosopis velutina) gum and its fractions Macromolecular Bioscience 8 749-757, 2008
DOI:10.1002/mabi.200700285
View abstract

Alonoso JM, Goycoolea FM, Higuera-Ciapara I Chitosan-polysaccharide blended nanoparticles for controlled drug delivery In Natural-Based Polymers for Biomedical Applications , 2008
DOI:10.1533/9781845694814.5.644

Cárdenas A, Goycoolea FM, Rinaudo M On the gelling behaviour of 'nopal' (Opuntia ficus indica) low methoxyl pectin Carbohydrate Polymers 73 212-222, 2008
DOI:10.1016/j.carbpol.2007.11.017
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Hernandez J, Goycoolea FM, Quintero J, Acosta A, Castañeda M, Dominguez Z, Robles R, Vazquez-Moreno L, Velazquez EF, Astiazaran H, Lugo E, Velazquez C Sonoran propolis: Chemical composition and antiproliferative activity on cancer cell lines Planta Medica 73 1469-1474, 2007
DOI:10.1055/s-2007-990244
View abstract

Velazquez C, Navarro M, Acosta A, Angulo A, Dominguez Z, Robles R, Robles-Zepeda R, Lugo E, Goycoolea FM, Velazquez EF, Astiazaran H, Hernandez J Antibacterial and free-radical scavenging activities of Sonoran propolis Journal of Applied Microbiology 103 1747-1756, 2007
DOI:10.1111/j.1365-2672.2007.03409.x
View abstract

Espinosa-García BM, Argüelles-Monal WM, Hernández J, Félix-Valenzuela L, Acosta N, Goycoolea FM Molecularly imprinted Chitosan - Genipin hydrogels with recognition capacity toward o-Xylene Biomacromolecules 8 3355-3364, 2007
DOI:10.1021/bm700458a
View abstract

Juárez J, Galaz JG, Machi L, Burboa M, Gutiérrez-Millán LE, Goycoolea FM, Valdez MA Interfacial behavior of N-nitrosodiethylamine/bovine serum albumin complexes at the air-water and the chloroform-water interfaces by axisymmetric drop tensiometry Journal of Physical Chemistry B 111 2727-2735, 2007
DOI:10.1021/jp066061m
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Meza-Nieto MA, Vallejo-Cordoba B, González-Córdova AF, Félix L, Goycoolea FM Effect ofβ-lactoglobulin A and B whey protein variants on the rennet-induced gelation of skim milk gels in a model reconstituted skim milk system Journal of Dairy Science 90 582-593, 2007
View abstract

Goycoolea FM, Argüelles-Monal WM, Lizardi J, Peniche C, Heras A, Galed G, Díaz EI Temperature and pH-sensitive chitosan hydrogels: DSC, rheological and swelling evidence of a volume phase transition Polymer Bulletin 58 225-234, 2007
DOI:10.1007/s00289-006-0590-7
View abstract

López-Franco YL, Goycoolea FM, Valdez MA, De La Barca AMC Mesquite gum; Alternative of industrial use Interciencia 31 183-189, 2006
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Acedo-Carrillo JI, Rosas-Durazo A, Herrera-Urbina R, Rinaudo M, Goycoolea FM, Valdez MA Zeta potential and drop growth of oil in water emulsions stabilized with mesquite gum Carbohydrate Polymers 65 327-336, 2006
DOI:10.1016/j.carbpol.2006.01.016
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Vázquez-Ortíz F, López-Franco Y, Goycoolea F Fractionation and characterization of the monosaccharides from mesquite prosopis spp. and arabic gum by normal, bonded phase, HPLC Journal of Liquid Chromatography and Related Technologies 29 1991-1999, 2006
DOI:10.1080/10826070600758183
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Díaz-Rojas EI, Argüelles-Monal WM, Higuera-Ciapara I, Hernández J, Lizardi-Mendoza J, Goycoolea FM Determination of chitin and protein contents during the isolation of chitin from shrimp waste Macromolecular Bioscience 6 340-347, 2006
DOI:10.1002/mabi.200500233
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Valdez MA, Acedo-Carrillo JI, Rosas-Durazo A, Lizardi J, Rinaudo M, Goycoolea FM Small-deformation rheology of mesquite gum stabilized oil in water emulsions Carbohydrate Polymers 64 205-211, 2006
DOI:10.1016/j.carbpol.2005.11.028
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Hernández J, Goycoolea FM, Zepeda-Rivera D, Juárez-Onofre J, Martínez K, Lizardi J, Salas-Reyes M, Gordillo B, Velázquez-Contreras C, García-Barradas O, Cruz-Sánchez S, Domínguez Z Substituent effects on the31P NMR chemical shifts of arylphosphorothionates Tetrahedron 62 2520-2528, 2006
DOI:10.1016/j.tet.2005.12.053
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Higuera-Ciapara I, Félix-Valenzuela L, Goycoolea FM Astaxanthin: A review of its chemistry and applications Critical Reviews in Food Science and Nutrition 46 185-196, 2006
DOI:10.1080/10408690590957188
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Parra-Barraza H, Burboa MG, Sánchez-Vázquez M, Juárez J, Goycoolea FM, Valdez MA Chitosan-cholesterol and chitosan-stearic acid interactions at the air-water interface Biomacromolecules 6 2416-2426, 2005
DOI:10.1021/bm050106s
View abstract

Félix L, Hernández J, Argüelles WM, Goycoolea FM Kinetics of gelation and thermal sensitivity of N-isobutyryl chitosan hydrogels Biomacromolecules 6 2408-2415, 2005
DOI:10.1021/bm0501297
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López-Franco YL, Valdez MA, Hernández J, Calderón De La Barca AM, Rinaudo M, Goycoolea FM Macromolecular dimensions and mechanical properties of monolayer films of sonorean mesquite gum Macromolecular Bioscience 4 865-874, 2004
DOI:10.1002/mabi.200400055
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Higuera-Ciapara I, Felix-Valenzuela L, Goycoolea FM, Argüelles-Monal W Microencapsulation of astaxanthin in a chitosan matrix Carbohydrate Polymers 56 41-45, 2004
DOI:10.1016/j.carbpol.2003.11.012
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Díaz-Rojas EI, Pacheco-Aguilar R, Lizardi J, Argüelles-Monal W, Valdez MA, Rinaudo M, Goycoolea FM Linseed pectin: Gelling properties and performance as an encapsulation matrix for shark liver oil Food Hydrocolloids 18 293-304, 2004
DOI:10.1016/S0268-005X(03)00085-7
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Goycoolea FM, Cárdenas A Pectins from Opuntia spp.: A short review Journal of the Professional Association for Cactus Development 5 17-29, 2003
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Goycoolea FM, Shirai K, Peter MG Chitin and Chitosan - Highlights from the Chitin Symposium 2002 in Acapulco, Mexico Macromolecular Bioscience 3 510-, 2003
DOI:10.1002/mabi.200390049

Cárdenas A, Argüelles-Monal W, Goycoolea FM, Higuera-Ciapara I, Peniche C Diffusion Through Membranes of the Polyelectrolyte Complex of Chitosan and Alginate Macromolecular Bioscience 3 535-539, 2003
DOI:10.1002/mabi.200300031
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Goycoolea FM, Heras A, Aranaz I, Galed G, Fernández-Valle ME, Argüelles-Monal W Effect of Chemical Crosslinking on the Swelling and Shrinking Properties of Thermal and pH-Responsive Chitosan Hydrogels Macromolecular Bioscience 3 612-619, 2003
DOI:10.1002/mabi.200300011
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Argüelles-Monal W, Goycoolea FM, Lizardi J, Peniche C, Higuera-Ciapara I Chitin and chitosan in gel network systems ACS Symposium Series 833 102-121, 2002

Rejón L, Ramírez A, Paz F, Goycoolea FM, Valdez MA Response time and electrorheology of semidiluted gellan, xanthan and cellulose suspensions Carbohydrate Polymers 48 413-421, 2002
DOI:10.1016/S0144-8617(01)00291-0
View abstract

Goycoolea FM, Milas M, Rinaudo M Associative phenomena in galactomannan-deacetylated xanthan systems International Journal of Biological Macromolecules 29 181-192, 2001
DOI:10.1016/S0141-8130(01)00164-7
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Brugnerotto J, Lizardi J, Goycoolea FM, Argüelles-Monal W, Desbrières J, Rinaudo M An infrared investigation in relation with chitin and chitosan characterization Polymer 42 3569-3580, 2001
DOI:10.1016/S0032-3861(00)00713-8
View abstract

Goycoolea FM, Argüelles-Monal W, Peniche C, Higuera-Ciapara I Chitin and chitosan Developments in Food Science 41 265-308, 2000
DOI:10.1016/S0167-4501(00)80013-8

Argüelles-Monal W, Goycoolea FM, Peniche C, Lizardi J, Higuera-Ciapara I Phase separation and gelation processes in alkali chitin American Chemical Society, Polymer Preprints, Division of Polymer Chemistry 41 703-704, 2000
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Goycoolea FM, Chronakis IS Specific methods for the analysis of identity and purity of functional food polysaccharides Developments in Food Science 39 99-140, 1998
DOI:10.1016/S0167-4501(98)80008-3

Valdez-González M, Valdez MA, Goycoolea FM Influence of salinity on the slip velocity of xanthan gum solutions Revista Mexicana de Fisica 44 277-281, 1998
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Goycoolea FM, Calderón De La Barca AM, Balderrama JR, Valenzuela JR Immunological and functional properties of the exudate gum from northwestern Mexican mesquite (Prosopis spp.) in comparison with gum arabic International Journal of Biological Macromolecules 21 29-36, 1997
DOI:10.1016/S0141-8130(97)00037-8
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Goycoolea FM, Nieblas JM, Noriega LO, Higuera-Ciapara I Temperature and concentration effects on the flow behaviour of stickwater Bioresource Technology 59 217-225, 1997
DOI:10.1016/S0960-8524(96)00145-9
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Ndjouenkeu R, Goycoolea FM, Morris ER, Akingbala JO Rheology of okra (Hibiscus esculentus L.) and dika nut (Irvingia gabonensis) polysaccharides Carbohydrate Polymers 29 263-269, 1996
DOI:10.1016/0144-8617(96)00016-1
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Goycoolea FM, Richardson RK, Morris ER, Gidley MJ Stoichiometry and Conformation of Xanthan in Synergistic Gelation with Locust Bean Gum or Konjac Glucomannan: Evidence for Heterotypic Binding Macromolecules 28 8308-8320, 1995
DOI:10.1021/ma00128a047
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Goycoolea FM, Morris ER, Gidley MJ Viscosity of galactomannans at alkaline and neutral pH: evidence of 'hyperentanglement' in solution Carbohydrate Polymers 27 69-71, 1995
DOI:10.1016/0144-8617(95)00030-B

Goycoolea FM, Morris ER, Richardson RK, Bell AE Solution rheology of mesquite gum in comparison with gum arabic Carbohydrate Polymers 27 37-45, 1995
DOI:10.1016/0144-8617(95)00031-2
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Goycoolea FM, Richardson RK, Morris ER, Gidley MJ Effect of locust bean gum and konjac glucomannan oh the conformation and rheology of agarose andκ‐carrageenan Biopolymers 36 643-658, 1995
DOI:10.1002/bip.360360510
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Goycoolea FM, Morris ER, Gidley MJ Screening for synergistic interactions in dilute polysaccharide solutions Carbohydrate Polymers 28 351-358, 1995
DOI:10.1016/0144-8617(95)00098-4
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Richardson RK, Goycoolea FM Rheological measurement ofκ-carrageenan during gelation Carbohydrate Polymers 24 223-225, 1994
DOI:10.1016/0144-8617(94)90134-1

ALMEIDADOMINGUEZ NG, HIGUERACIAPARA I, GOYCOOLEA FM, VALENCIA ME PACKAGE, TEMPERATURE AND TBHQ EFFECTS ON OXIDATIVE DETERIORATION OF CORN-BASED SNACKS JOURNAL OF FOOD SCIENCE 57 112-117, 1992
DOI:10.1111/j.1365-2621.1992.tb05436.x

Goycoolea F, González de Mejía E, Barrón JM, Valencia ME Effect of home-processing in the preparation of pinto beans (Phaseolus vulgaris L.) on the tannin content and nutritive value of proteins Archivos Latinoamericanos de Nutricion 40 263-274, 1990
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