School of Food Science and Nutrition

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Yun Yun Gong

Associate Professor in International Food Security & Safety
Research section: Food Chemistry and Biochemistry

Contact details

Room: P2.21a
Tel: +44 (0)113 3431415
Email: Y.Gong@leeds.ac.uk

Keywords

Dietary ExposureBiomarker
Human Health Risk assessment
Food safety
Aflatoxin/Mycotoxins
Molecular Epidemiology
Early Life Exposure
Cancer risk factors
Food Safety in China

Photograph of Yun Yun Gong

Research interests


  • Exposure biomarkers to assess dietary exposure to food born natural toxins such as mycotoxins.
  • Epidemiology studies to investigate the impact of exposure to mycotoxins on human health, in high risk regions (e.g. sub-Sahara Africa) with a focus on cancer, child malnutrition, and reproductive function.
  • Laboratory in vitro study to understand the mechanism of mycotoxins on human health.
  • Evaluate interventions to mitigate mycotoxins, using sustainable methods such as post-harvest storage improvement and public education.
  • Dietary exposure and cancer.
  • Food safety, exposure and risk assessment in China.

I have built a wide collaborative network with scientists in the International Agency for Research on Cancer (IARC), the London School of Hygiene and Tropical Medicine (LSHTM), The Tanzania Food and Drug Authority (TFDA), the MRC Unit Gambia, MRC South Africa and the MRC Unit in Uganda, and China Food Safety Risk Assessment Center (CFSA).

Some of my recent research projects:

  • Partnership for Aflatoxin Control in Africa (PACA): Aflatoxin exposure and associated immune function damage in young children (Co-I)
  • Bill and Melinda Gates Foundation: Understanding mechanisms and identifying biomarkers for the relationship between aflatoxin exposure and child stunting (PI)
  • Bill and Melinda Gates Foundation: Mycotoxins as a Risk Factor in Childhood Growth Impairment Worldwide (Co-I)
  • Leverhulme - Royal Society Africa Award: Evaluation of Dietary Exposure to Mycotoxins in Young Children (PI)

I was a working group member evaluating aflatoxin and human health for the WHO/IARC in 2014. In 2014 I led a group of global experts, prepared scientific reports on aflatoxin impact on human health and delivered workshops to the East Africa Community (EAC), providing scientific guidance on food policy and regulations. I have been serving the European Food Safety Authority (EFSA) as a working group member conducting risk assessment on food mycotoxins over the last six years. Currently I hold a research leadership position (honorary) in the CFSA in Beijing, China.

Publications

Routledge MN, Gong YY Molecular epidemiology of aflatoxin exposure and child health MUTAGENESIS 27 797-797, 2012

Gong YY, Wilson S, Mwatha JK, Routledge MN, Castelino JM, Zhao B, Kimani G, Kariuki HC, Vennervald BJ, Dunne DW, Wild CP Aflatoxin exposure may contribute to chronic hepatomegaly in Kenyan school children. Environ Health Perspect 120 893-896, 2012
DOI:10.1289/ehp.1104357
View abstract

Turner* PC, Gong* YY, Routledge MN, Pourshams A, Malekzadeh R, Islami F, Jafari E, Wild CP, Islami F, Boffetta P, Islami F, Boffetta P A pilot survey for Fusarium mycotoxin biomarkers in women from Golestan, Northern Iran World Mycotoxin Journal 5 195-199, 2012
DOI:10.3920/WMJ2011.1337
View abstract

van der Westhuizen L, Shephard GS, Burger HM, Rheeder JP, Gelderblom WCA, Wild CP, Gong YY Fumonisin B1 as a urinary biomarker of exposure in a maize intervention study among South African subsistence farmers. Cancer Epidemiol Biomarkers Prev 20 483-489, 2011
DOI:10.1158/1055-9965.EPI-10-1002
View abstract

Van der Westhuizen L, Shephard GS, Rheeder JP, Burger H-M, Gelderblom WCA, Wild CP, Gong YY Optimising sorting and washing of home-grown maize to reduce fumonisin contamination under laboratory-controlled conditions Food Control 22 396-400, 2011

Routledge MN, Gong YY Developing biomarkers of human exposure to mycotoxins In Determining Mycotoxins and Mycotoxigenic Fungi in Food and Feed , 2010
View abstract

van der Westhuizen L, Shephard GS, Rheeder JP, Burger HM, Gelderblom WCA, Wild CP, Gong YY Simple intervention method to reduce fumonisin exposure in a subsistence maize-farming community in South Africa FOOD ADDIT CONTAM A 27 1582-1588, 2010
DOI:10.1080/19440049.2010.508050

Wild CP, Gong YY Mycotoxins and human disease: a largely ignored global health issue CARCINOGENESIS 31 71-82, 2010
DOI:10.1093/carcin/bgp264

Gong YY Urinary fumonisin B-1 biomarker validation and application in intervention studies Gong YY, van der Westhuizen L, Shephard GS, Burger HM, Rheeder JP, Gelderblom WCA, Wild CP Urinary fumonisin B-1 biomarker validation and application in intervention studies Gong YY, van der Westhuizen L, Shephard GS, Burger HM, Rheeder JP, Gelderblom WCA, Wild CP MUTAGENESIS 24 , 2009

Szymañska K, Chen J-G, Cui Y, Gong YY, Turner PC, Villar S, Wild CP, Parkin DM, Hainaut P TP53 R249S mutations, exposure to aflatoxin, and occurrence of hepatocellular carcinoma in a cohort of chronic hepatitis B virus carriers from Qidong, China. Cancer Epidemiol Biomarkers Prev 18 1638-1643, 2009
DOI:10.1158/1055-9965.EPI-08-1102
View abstract

Meissonnier GM, Pinton P, Laffitte J, Cossalter AM, Gong YY, Wild CP, Bertin G, Galtier P, Oswald IP Immunotoxicity of aflatoxin B1: Impairment of the cell-mediated response to vaccine antigen and modulation of cytokine expression TOXICOL APPL PHARM 231 142-149, 2008
DOI:10.1016/j.taap.2008.04.004

Mccoy LF, Scholl PF, Sutcliffe AE, Kieszak SM, Powers CD, Rogers HS, Gong YY, Groopman JD, Wild CP, Schleicher RL Human aflatoxin albumin adducts quantitatively compared by ELISA, HPLC with fluorescence detection, and HPLC with isotope dilution mass spectrometry CANCER EPIDEM BIOMAR 17 1653-1657, 2008
DOI:10.1158/1055-9965.EPI-07-2780

Gong YY, Torres-Sanchez L, Lopez-Carrillo L, Peng JH, Sutcliffe AE, White KL, Humpf H-U, Turner PC, Wild CP Association between tortilla consumption and human urinary fumonisin B1 levels in a Mexican population. Cancer Epidemiol Biomarkers Prev 17 688-694, 2008
DOI:10.1158/1055-9965.EPI-07-2534
View abstract

Turner PC, Rothwell JA, White KLM, Gong YY, Cade JE, Wild CP Urinary deoxynivalenol is correlated with cereal intake in individuals form the United Kingdom Environment Health Perspectives 116 21-25, 2008

Gong YY, Turner PC, Hall AJ, Wild CP Aflatoxin exposure and impaired child growth in West Africa: An unexplored international public health burden? In Mycotoxins Detection Methods, Management, Public Health and Agricultural Trade , 2008

Turner PC, Collinson AC, Cheung YC, Gong YY, Hall AJ, Prentice AM, Wild CP Aflatoxin exposure in utero causes growth faltering in Gambian infants International Journal of Epidemiology 36 1119-1125, 2007
DOI:10.1093/ije/dym122

Turner PC, Rothwell J, White KLM, Gong YY, Cade JE, Wild CP Urinary deoxynivalenol is correlated with cereal intake in individuals from the UK, 2007
DOI:10.1289/ehp.10663

Di Martino E, Hardie LJ, Wild CP, Gong YY, Olliver JR, Gough MD, Bird NC The NAD(P)H: quinone oxidoreductase I C609T polymorphism modifies the risk of Barrett's esophagus and esophageal adenocarcinoma Genetics in Medicine 9 341-347, 2007
DOI:10.1097/GIM.0b013e3180654ccd

Polychronaki N, Turner PC, Mykkanen H, Gong YY, Amra H, Abdel-Wahhab M, El-Nezami H Determinants of aflatoxin M-1 in breast milk of Egyptian mothers Food Additives and Contaminants 23 700-708, 2006
DOI:10.1080/02652030600627222
View abstract

Scussel VM, Haas P, Gong YY, Turner PC, Wild CP Study of aflatoxin exposure in a Brazilian population using an aflatoxin-albumin biomarker In Mycotoxins and phycotoxins: Advances in determination, toxicology and exposure management. , 2006

Egal S, Hounsa A, Gong YY, Turner PC, Wild CP, Hall AJ, Hell K, Cardwell KF Dietary exposure to aflatoxin from maize and groundnut in young children from Benin and Togo, West Africa INT J FOOD MICROBIOL 104 215-224, 2005
DOI:10.1016/j.ijfoodmicro.2005.03.004

Turner PC, Sylla A, Gong YY, Diallo MS, Sutcliffe AE, Hall AJ, Wild CP Reduction in exposure to carcinogenic aflatoxins by postharvest intervention measures in west Africa: a community-based intervention study. Lancet 365 1950-1956, 2005
DOI:10.1016/S0140-6736(05)66661-5
View abstract

Olliver JR, Hardie LJ, Gong YY, Dexter S, Chalmers D, Harris K, Cowan M, Wild CP DNA damage, risk factors, and disease progression in Barrett's oesophagus GUT 54 , 2005

Olliver JR, Hardie LJ, Gong YY, Dexter SPL, Chalmers DM, Harris KM, Wild CP Risk Factors, DNA Damage, and Disease Progression in Barrett's Esophagus Cancer Epidemiology, Biomarkers&Prevention 14 620-625, 2005
DOI:10.1158/1055-9965.EPI-04-0509

Kirk GD, Turner PC, Gong YY, Lesi OA, Mendy M, Goedert JJ, Hall AJ, Whittle H, Hainaut P, Montesano R, Wild CP Hepatocellular Carcinoma and Polymorphisms in Carcinogen-Metabolizing and DNA Repair Enzymes in a Population with Aflatoxin Exposure and Hepatitis B Virus Endemicity Cancer Epidemiology, Biomarkers&Prevention 14 373-379, 2005
DOI:10.1158/1055-9965.EPI-04-0161

Gong YY, Wild CP Aflatoxin in West Africa: exposure, susceptibility and prevention, 2005

Gong YY, Turner PC, Hounsa A, White KL, Cardwell KF, Egal S, Hall AJ, Wild CP Dietary exposure to human hepatocarcinogens, aflatoxins, micronutrient deficiency, and child growth in Benin, West Africa. J NUTR 134 , 2004

Gong YY, Hounsa A, Egal S, Turner PC, Sutcliffe AE, Hall AJ, Cardwell K, Wild CP Post-weaning exposure to aflatoxin results in impaired child growth: a longitudinal study in Benin, West Africa Environmental Health Perspectives 112 1334-1338, 2004

Wyatt J, Baker H, Prasad P, Gong YY, Millson C Steatosis and fibrosis in patients with chronic hepatitis C. J Clin Pathol 57 402-406, 2004
View abstract

Gong YY, Egal S, Hounsa A, Turner PC, Hall A, Cardwell K, Wild CP Determinants of aflatoxin exposure in young children from Benin and Togo, West Africa: the critical role of weaning International Journal of Epidemiology 32 556-562, 2003
DOI:10.1093/ije/dyg109

Winter JP, Gong YY, Grant PJ, Wild CP Glutathione peroxidase 1 genotype is associated with an increased risk of coronary artery disease CORONARY ARTERY DIS 14 149-153, 2003
DOI:10.1097/01.mca.0000061618.36552.10

Winter JP, Gong YY, Grant PJ, Wild CP Glutathione peroxidase 1 genotype is associated with an increased risk of coronary artery disease Coronary Artery Disease 14 149-153, 2003
DOI:10.1097/00019501-200304000-00007

Baker H, Prasad P, Gong YY, Millson C, Wyatt J Steatosis in chronic hepatitis C, association with disease stage and necroinflammatory activity Journal of Pathology 198 pp.S-, 2002

Baker H, Prasad P, Gong YY, Millson C, Wyatt J Steatosis in chronic hepatitis C, association with disease stage and necroinflammatory activity J PATHOL 198 38A-38A, 2002

Gong YY, Cardwell K, Hounsa A, Egal S, Turner PC, Hall AJ, Wild CP Dietary aflatoxin exposure and impaired growth in young children from Benin and Togo: cross sectional study BRIT MED J 325 20-21, 2002

Gong YY, Han C, Chen JS Effect of tea polyphenols and tea pigments on the inhibition of precancerous liver lesions in rats Nutrition and Cancer 38 81-86, 2000

Gong YY Fumonisin intervention study– effect of handsorting and washing,

Gong YY Urinary fumonisin biomarker development,

Gong YY Biomarker application in an intervention study to reduce fumonisins,

Gong YY Mycotoxins: Detection, Health, Risk and Control,

Gong YY Mycotoxin and human health: a global food safety perspective,