School of Food Science and Nutrition

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Christine Bosch

Lecturer in Nutrition and Deputy Postgraduate Research Tutor
Research section: Nutrition and Public Health

Contact details

Room: P2.31
Tel: +44 (0)113 3430268
Email: C.Bosch@leeds.ac.uk

Keywords

diet and health
secondary plant metabolites
flavonoids
oxidative stress and inflammation
molecular nutrition
functional food
gene-nutrient interactions
trace element metabolism and interactions

Photograph of Christine Bosch

Research interests

I have a strong interest in nutrition related research with focus on health promoting effects of dietary antioxidants and their mechanism of action.

  • The potential of different flavonoids to alter cell signalling pathways and gene expression in the context of oxidative stress and inflammation
  • Impact of plant secondary metabolites in the prevention and/or intervention of oxidative stress and inflammation related diseases such as obesity, diabetes and cardiovascular diseases.
  • Contribution of metabolism, genetic variation and epigenetic factors to gene regulation
  • Interactions of trace elements with redox regulated pathways
  • Implementation of molecular methods in nutrition research

Useful links

Bosch publications (PubMed)   
   
   

Publications

Bosch C Effects of flavonoids on skin protective mechanisms BRITISH JOURNAL OF DERMATOLOGY 175 , 2016

Schneider SA, Scharffetter C, Wagner AE, Boesch C, Bruchhaus I, Rimbach G, Roeder T Social stress increases the susceptibility to infection in the ant Harpegnathos saltator Scientific Reports 6 -, 2016
DOI:10.1038/srep25800
View abstract

Bosch C, Sadeghpour A, Rappolt M, Birch-Machin M Differential protective effects of flavonols towards mitochondrial stress British Journal of Dermatology 174 , 2016
DOI:10.1111/bjd.14560

Moreno-Fernandez J, Diaz-Castro J, Pulido-Moran M, Alferez MJM, Bosch C, Sanchez-Alcover A, López-Aliaga I Fermented Goat’s Milk Consumption Improves Duodenal Expression of Iron Homeostasis Genes during Anemia Recovery Journal of Agricultural and Food Chemistry 64 2560-2568, 2016
DOI:10.1021/acs.jafc.6b00108
View abstract

Boesch C, Watson N, Orfila C Impact of food processing on total polyphenol content and in vitro antioxidant activity in different sorghum varieties PROCEEDINGS OF THE NUTRITION SOCIETY 74 , 2015
DOI:10.1017/S0029665115003705

Bosch C, Lietz G, Birch-Machin M Effects of polyphenols on mitochondrial DNA damage in skin fibroblasts BRITISH JOURNAL OF DERMATOLOGY 170 , 2014

Weigand E, Boesch-Saadatmandi C Apparent zinc absorption and zinc status of weanling rats fed moderately zinc-deficient diets enriched with beef tallow or sunflower oil Journal of Animal Physiology and Animal Nutrition 97 710-719, 2013
DOI:10.1111/j.1439-0396.2012.01313.x
View abstract

Pfeuffer M, Auinger A, Bley U, Kraus-Stojanowic I, Laue C, Winkler P, Ruefer CE, Frank J, Boesch-Saadatmandi C, Rimbach G, Schrezenmeir J Effect of quercetin on traits of the metabolic syndrome, endothelial function and inflammation in men with different APOE isoforms NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES 23 403-409, 2013
DOI:10.1016/j.numecd.2011.08.010

Stachurska A, Ciesla M, Kozakowska M, Wolffram S, Boesch-Saadatmandi C, Rimbach G, Jozkowicz A, Dulak J, Loboda A Cross-talk between microRNAs, nuclear factor E2-related factor 2, and heme oxygenase-1 in ochratoxin A-induced toxic effects in renal proximal tubular epithelial cells Molecular Nutrition and Food Research 57 504-515, 2013
DOI:10.1002/mnfr.201200456
View abstract

Boesch-Saadatmandi C, Wagner AE, Wolffram S, Rimbach G Effect of quercetin on inflammatory gene expression in mice liver in vivo - Role of redox factor 1, miRNA-122 and miRNA-125b Pharmacological Research 65 523-530, 2012
DOI:10.1016/j.phrs.2012.02.007
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Wagner AE, Boesch-Saadatmandi C, Dose J, Schultheiss G, Rimbach G Anti-inflammatory potential of allyl-isothiocyanate--role of Nrf2, NF-(κ) B and microRNA-155. J Cell Mol Med 16 836-843, 2012
DOI:10.1111/j.1582-4934.2011.01367.x
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Weigand E, Boesch-Saadatmandi C Interaction between marginal zinc and high fat supply on lipid metabolism and growth of weanling rats Lipids 47 291-302, 2012
DOI:10.1007/s11745-011-3629-y
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Lietz G, Oxley A, Boesch-Saadatmandi C, Kobayashi D Importance ofβ,β-carotene 15,15′-monooxygenase 1 (BCMO1) and β,β-carotene 9′,10′-dioxygenase 2 (BCDO2) in nutrition and health Molecular Nutrition and Food Research 56 241-250, 2012
DOI:10.1002/mnfr.201100387
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Graeser A-C, Boesch-Saadatmandi C, Lippmann J, Wagner AE, Huebbe P, Storm N, Höppner W, Wiswedel I, Gardemann A, Minihane AM, Döring F, Rimbach G Nrf2-dependent gene expression is affected by the proatherogenic apoE4 genotype-studies in targeted gene replacement mice. J Mol Med (Berl) 89 1027-1035, 2011
DOI:10.1007/s00109-011-0771-1
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Huebbe P, Nebel A, Siegert S, Moehring J, Boesch-Saadatmandi C, Most E, Pallauf J, Egert S, Müller MJ, Schreiber S, Nöthlings U, Rimbach G APOEε4 is associated with higher vitamin D levels in targeted replacement mice and humans. FASEB J 25 3262-3270, 2011
DOI:10.1096/fj.11-180935
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Lüersen K, Schmelzer C, Boesch-Saadatmandi C, Kohl C, Rimbach G, Döring F Paraoxonase 1 polymorphism Q192R affects the pro-inflammatory cytokine TNF-alpha in healthy males. BMC Res Notes 4 141-, 2011
DOI:10.1186/1756-0500-4-141
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Boesch-Saadatmandi C, Loboda A, Wagner AE, Stachurska A, Jozkowicz A, Dulak J, Döring F, Wolffram S, Rimbach G Effect of quercetin and its metabolites isorhamnetin and quercetin-3-glucuronide on inflammatory gene expression: role of miR-155. J Nutr Biochem 22 293-299, 2011
DOI:10.1016/j.jnutbio.2010.02.008
View abstract

Schneider SA, Schrader C, Wagner AE, Boesch-Saadatmandi C, Liebig J, Rimbach G, Roeder T Stress resistance and longevity are not directly linked to levels of enzymatic antioxidants in the ponerine ant Harpegnathos saltator. PLoS One 6 e14601-, 2011
DOI:10.1371/journal.pone.0014601
View abstract

Wagner AE, Boesch-Saadatmandi C, Breckwoldt D, Schrader C, Schmelzer C, Döring F, Hashida K, Hori O, Matsugo S, Rimbach G Ascorbic acid partly antagonizes resveratrol mediated heme oxygenase-1 but not paraoxonase-1 induction in cultured hepatocytes - role of the redox-regulated transcription factor Nrf2. BMC Complement Altern Med 11 1-, 2011
DOI:10.1186/1472-6882-11-1
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Boesch-Saadatmandi C, Rimbach G, Jungblut A, Frank J Comparison of tetrahydrofuran, fetal calf serum, and Tween 40 for the delivery of astaxanthin and canthaxanthin to HepG2 cells. Cytotechnology 63 89-97, 2011
DOI:10.1007/s10616-010-9324-7
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Boesch-Saadatmandi C, Rimbach G, Schrader C, Kofler BM, Armah CK, Minihane AM Determinants of paraoxonase activity in healthy adults. Mol Nutr Food Res 54 1842-1850, 2010
DOI:10.1002/mnfr.201000190
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Boesch-Saadatmandi C, Niering J, Minihane AM, Wiswedel I, Gardeman A, Wolffram S, Rimbach G Impact of apolipoprotein E genotype and dietary quercetin on paraoxonase 1 status in apoE3 and apoE4 transgenic mice. Atherosclerosis 211 110-113, 2010
DOI:10.1016/j.atherosclerosis.2010.02.027
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Wiegand H, Boesch-Saadatmandi C, Wein S, Wolffram S, Frank J, Rimbach G Dietary flavonoids do not affect vitamin E status in growing rats. J Anim Physiol Anim Nutr (Berl) 94 307-318, 2010
DOI:10.1111/j.1439-0396.2008.00910.x
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Röhl C, Armbrust E, Herbst E, Jess A, Gülden M, Maser E, Rimbach G, Bösch-Saadatmandi C Mechanisms involved in the modulation of astroglial resistance to oxidative stress induced by activated microglia: antioxidative systems, peroxide elimination, radical generation, lipid peroxidation. Neurotoxicity research 17 317-331, 2010
DOI:10.1007/s12640-009-9108-z
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Huebbe P, Wagner AE, Boesch-Saadatmandi C, Sellmer F, Wolffram S, Rimbach G Effect of dietary quercetin on brain quercetin levels and the expression of antioxidant and Alzheimer's disease relevant genes in mice. Pharmacol Res 61 242-246, 2010
DOI:10.1016/j.phrs.2009.08.006
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Boesch-Saadatmandi C, Egert S, Schrader C, Coumoul X, Barouki R, Muller MJ, Wolffram S, Rimbach G Effect of quercetin on paraoxonase 1 activity--studies in cultured cells, mice and humans. J Physiol Pharmacol 61 99-105, 2010
View abstract

Egert S, Boesch-Saadatmandi C, Wolffram S, Rimbach G, Müller MJ Serum lipid and blood pressure responses to quercetin vary in overweight patients by apolipoprotein E genotype Journal of Nutrition 140 278-284, 2010
DOI:10.3945/jn.109.117655
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Graeser A-C, Giller K, Wiegand H, Barella L, Boesch Saadatmandi C, Rimbach G Synergistic chondroprotective effect of alpha-tocopherol, ascorbic acid, and selenium as well as glucosamine and chondroitin on oxidant induced cell death and inhibition of matrix metalloproteinase-3--studies in cultured chondrocytes. Molecules 15 27-39, 2009
DOI:10.3390/molecules15010027
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Boesch-Saadatmandi C, Wagner AE, Graeser AC, Hundhausen C, Wolffram S, Rimbach G Ochratoxin A impairs Nrf2-dependent gene expression in porcine kidney tubulus cells. J Anim Physiol Anim Nutr (Berl) 93 547-554, 2009
DOI:10.1111/j.1439-0396.2008.00838.x
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Boesch-Saadatmandi C, Pospissil RT, Graeser A-C, Canali R, Boomgaarden I, Doering F, Wolffram S, Egert S, Mueller MJ, Rimbach G Effect of quercetin on paraoxonase 2 levels in RAW264.7 macrophages and in human monocytes--role of quercetin metabolism. Int J Mol Sci 10 4168-4177, 2009
DOI:10.3390/ijms10094168
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Gaedicke S, Zhang X, Huebbe P, Boesch-Saadatmandi C, Lou Y, Wiswedel I, Gardemann A, Frank J, Rimbach G Dietary vitamin E, brain redox status and expression of Alzheimer's disease-relevant genes in rats. Br J Nutr 102 398-406, 2009
DOI:10.1017/S000711450819122X
View abstract

Stachurska A, Loboda A, Kozakowska M, Boesch-Saadatmandi C, Rimbach G, Yla-Herttuala S, Levonen AL, Jozkowicz A, Dulak J Attenuation of Nrf2 expression and antioxidant response by ochratoxin A - the impact on the profibrotic effect FEBS JOURNAL 276 224-224, 2009

Boesch-Saadatmandi C, Wolffram S, Minihane AM, Rimbach G Effect of apoE genotype and dietary quercetin on blood lipids and TNF-alpha levels in apoE3 and apoE4 targeted gene replacement mice. Br J Nutr 101 1440-1443, 2009
DOI:10.1017/S0007114508102434
View abstract

Roehl C, Armbrust E, Herbst E, Jess A, Guelden M, Maser E, Boesch-Saadatmandi C Microglia-mediated increase of heme oxygenase-1 (HO-1), superoxide dismutase-2 (Sod-2) and glutathione and the effect of microglia on peroxide-induced generation of radical species and lipid peroxidation in astrocytes in vitro NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY 379 67-67, 2009

Zhang X, Boesch-Saadatmandi C, Lou Y, Wolffram S, Huebbe P, Rimbach G Ochratoxin A induces apoptosis in neuronal cells Genes and Nutrition 4 41-48, 2009
DOI:10.1007/s12263-008-0109-y
View abstract

Wiegand H, Wagner AE, Boesch-Saadatmandi C, Kruse H-P, Kulling S, Rimbach G Effect of dietary genistein on Phase II and antioxidant enzymes in rat liver. Cancer Genomics Proteomics 6 85-92, 2009
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Wiegand H, Boesch-Saadatmandi C, Regos I, Treutter D, Wolffram S, Rimbach G Effects of quercetin and catechin on hepatic glutathione-S transferase (GST), NAD(P)H quinone oxidoreductase 1 (NQO1), and antioxidant enzyme activity levels in rats. Nutr Cancer 61 717-722, 2009
DOI:10.1080/01635580902825621
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Augustin K, Blank R, Boesch-Saadatmandi C, Frank J, Wolffram S, Rimbach G Dietary green tea polyphenols do not affect vitamin E status, antioxidant capacity and meat quality of growing pigs. J Anim Physiol Anim Nutr (Berl) 92 705-711, 2008
DOI:10.1111/j.1439-0396.2007.00768.x
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Hundhausen C, Boesch-Saadatmandi C, Matzner N, Lang F, Blank R, Wolffram S, Blaschek W, Rimbach G Ochratoxin a lowers mRNA levels of genes encoding for key proteins of liver cell metabolism. Cancer Genomics Proteomics 5 319-332, 2008
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Egert S, Wolffram S, Bosy-Westphal A, Boesch-Saadatmandi C, Wagner AE, Frank J, Rimbach G, Mueller MJ Daily quercetin supplementation dose-dependently increases plasma quercetin concentrations in healthy humans. J Nutr 138 1615-1621, 2008
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Boesch-Saadatmandi C, Loboda A, Jozkowicz A, Huebbe P, Blank R, Wolffram S, Dulak J, Rimbach G Effect of ochratoxin A on redox-regulated transcription factors, antioxidant enzymes and glutathione-S-transferase in cultured kidney tubulus cells. Food Chem Toxicol 46 2665-2671, 2008
DOI:10.1016/j.fct.2008.04.023
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Jofre-Monseny L, Huebbe P, Stange I, Boesch-Saadatmandi C, Frank J, Jackson K, Minihane A-M, Rimbach G Influence of apolipoprotein E genotype and dietary alpha-tocopherol on redox status and C-reactive protein levels in apolipoprotein E3 and E4 targeted replacement mice. Br J Nutr 100 44-53, 2008
DOI:10.1017/S000711450788634X
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Rimbach G, Boesch-Saadatmandi C, Frank J, Fuchs D, Wenzel U, Daniel H, Hall WL, Weinberg PD Dietary isoflavones in the prevention of cardiovascular disease--a molecular perspective. Food Chem Toxicol 46 1308-1319, 2008
DOI:10.1016/j.fct.2007.06.029
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Huebbe P, Schaffer S, Jofre-Monseny L, Boesch-Saadatmandi C, Minihane AM, Müller WE, Eckert GP, Rimbach G Apolipoprotein E genotype and alpha-tocopherol modulate amyloid precursor protein metabolism and cell cycle regulation Molecular Nutrition and Food Research 51 1510-1517, 2007
DOI:10.1002/mnfr.200700194
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Boesch-Saadatmandi C, Most E, Weigand E Influence of dietary fat and zinc supplementation on the iron utilization in growing rats Annals of Nutrition and Metabolism 51 395-401, 2007
DOI:10.1159/000108107
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Huebbe P, Jofre-Monseny L, Boesch-Saadatmandi C, Minihane A-M, Rimbach G Effect of apoE genotype and vitamin E on biomarkers of oxidative stress in cultured neuronal cells and the brain of targeted replacement mice JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY 58 683-698, 2007

Egert S, Rassoul F, Boesch-Saadatmandi C, Richter V, Rimbach G, Erbersdobler HF, Somoza V, Wahrburg U Effects of controlled diets enriched with alpha-linolenic acid, eicosapentaenoic acid or docosahexaenoic acid on soluble adhesion molecules and endothelin-1 concentrations in healthy volunteers Current Topics in Nutraceutical Research 5 189-195, 2007
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Jofre-Monseny L, Loboda A, Wagner AE, Huebbe P, Boesch-Saadatmandi C, Jozkowicz A, Minihane AM, Dulak J, Rimbach G Effects of apoE genotype on macrophage inflammation and heme oxygenase-1 expression Biochemical and Biophysical Research Communications 357 319-324, 2007
DOI:10.1016/j.bbrc.2007.03.150
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Jofre-Monseny L, de Pascual-Teresa S, Plonka E, Huebbe P, Boesch-Saadatmandi C, Minihane AM, Rimbach G Differential effects of apolipoprotein E3 and E4 on markers of oxidative status in macrophages British Journal of Nutrition 97 864-871, 2007
DOI:10.1017/S0007114507669219
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Boesch-Saadatmandi C, Hundhausen C, Jofre-Monseny L, Blank R, Wolffram S, Rimbach G Ochratoxin A-induced cytotoxicity in liver (HepG2) cells: Impact of serum concentration, dietary antioxidants and glutathione-modulating compounds JOURNAL OF APPLIED BOTANY AND FOOD QUALITY-ANGEWANDTE BOTANIK 80 179-186, 2006

Hundhausen C, Bösch-Saadatmandi C, Augustin K, Blank R, Wolffram S, Rimbach G Effect of vitamin E and polyphenols on ochratoxin A-induced cytotoxicity in liver (HepG2) cells Journal of Plant Physiology 162 818-822, 2005
DOI:10.1016/j.jplph.2005.04.021
View abstract